The Impact of Molecular Biology in the Seeding, Treatment Choices and Follow-Up of Colorectal Cancer Liver Metastases—A Narrative Review
There is a clear association between the molecular profile of colorectal cancer liver metastases (CRCLM) and the degree to which aggressive progression of the disease impacts patient survival. However, much of our knowledge of the molecular behaviour of colorectal cancer cells comes from experimental studies with, as yet, limited application in clinical practice. In this article, we review the current advances in the understanding of the molecular behaviour of CRCLM and present possible future therapeutic applications. This review focuses on three important steps in CRCLM development, progression and treatment: (1) the dissemination of malignant cells from primary tumours and the seeding to metastatic sites; (2) the response to modern regimens of chemotherapy; and (3) the possibility of predicting early progression and recurrence patterns by molecular analysis in liquid biopsy..
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:24 |
|---|---|
| Enthalten in: |
International Journal of Molecular Sciences - 24(2023), 2, p 1127 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Mihai-Calin Pavel [VerfasserIn] |
|---|
| Links: |
doi.org [kostenfrei] |
|---|
| Themen: |
Biology (General) |
|---|
| doi: |
10.3390/ijms24021127 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
DOAJ081783442 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | DOAJ081783442 | ||
| 003 | DE-627 | ||
| 005 | 20240414132855.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 230310s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.3390/ijms24021127 |2 doi | |
| 035 | |a (DE-627)DOAJ081783442 | ||
| 035 | |a (DE-599)DOAJ8f7d032393b74b4cad8f68f1db5a775e | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 050 | 0 | |a QH301-705.5 | |
| 050 | 0 | |a QD1-999 | |
| 100 | 0 | |a Mihai-Calin Pavel |e verfasserin |4 aut | |
| 245 | 1 | 4 | |a The Impact of Molecular Biology in the Seeding, Treatment Choices and Follow-Up of Colorectal Cancer Liver Metastases—A Narrative Review |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 520 | |a There is a clear association between the molecular profile of colorectal cancer liver metastases (CRCLM) and the degree to which aggressive progression of the disease impacts patient survival. However, much of our knowledge of the molecular behaviour of colorectal cancer cells comes from experimental studies with, as yet, limited application in clinical practice. In this article, we review the current advances in the understanding of the molecular behaviour of CRCLM and present possible future therapeutic applications. This review focuses on three important steps in CRCLM development, progression and treatment: (1) the dissemination of malignant cells from primary tumours and the seeding to metastatic sites; (2) the response to modern regimens of chemotherapy; and (3) the possibility of predicting early progression and recurrence patterns by molecular analysis in liquid biopsy. | ||
| 650 | 4 | |a colorectal cancer liver metastasis | |
| 650 | 4 | |a molecular biology | |
| 650 | 4 | |a monoclonal antibodies | |
| 650 | 4 | |a follow-up | |
| 653 | 0 | |a Biology (General) | |
| 653 | 0 | |a Chemistry | |
| 700 | 0 | |a Elena Ramirez-Maldonado |e verfasserin |4 aut | |
| 700 | 0 | |a Eva Pueyo-Périz |e verfasserin |4 aut | |
| 700 | 0 | |a Robert Memba |e verfasserin |4 aut | |
| 700 | 0 | |a Sandra Merino |e verfasserin |4 aut | |
| 700 | 0 | |a Justin Geoghegan |e verfasserin |4 aut | |
| 700 | 0 | |a Rosa Jorba |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i In |t International Journal of Molecular Sciences |d MDPI AG, 2003 |g 24(2023), 2, p 1127 |w (DE-627)DOAJ00014584X |x 14220067 |7 nnns |
| 773 | 1 | 8 | |g volume:24 |g year:2023 |g number:2, p 1127 |
| 856 | 4 | 0 | |u https://doi.org/10.3390/ijms24021127 |z kostenfrei |
| 856 | 4 | 0 | |u https://doaj.org/article/8f7d032393b74b4cad8f68f1db5a775e |z kostenfrei |
| 856 | 4 | 0 | |u https://www.mdpi.com/1422-0067/24/2/1127 |z kostenfrei |
| 856 | 4 | 2 | |u https://doaj.org/toc/1661-6596 |y Journal toc |z kostenfrei |
| 856 | 4 | 2 | |u https://doaj.org/toc/1422-0067 |y Journal toc |z kostenfrei |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_DOAJ | ||
| 951 | |a AR | ||
| 952 | |d 24 |j 2023 |e 2, p 1127 | ||