Association of vitamin D status with disease severity and outcome in Indian patients with IgA nephropathy
Abstract Background Vitamin D deficiency has been examined as a risk factor for severity and progression of kidney disease due to its immunomodulatory effects. There is paucity of data about its impact in IgA nephropathy (IgAN). Methods In a retrospective cohort study, 25 (OH) vitamin D assay was performed in bio-banked baseline serum samples collected during kidney biopsy of 105 adult patients with primary IgAN diagnosed between 2015 and 2019. A level of < 10 ng/mL was defined as Vitamin D deficiency. Results Mean age of patients was 34 ± 10.6 years, 69.5% were males. Mean baseline 25(OH) Vitamin D levels was 15.9 ± 11.9 ng/mL and 41(39%) patients had vitamin D deficiency. Serum albumin level was lower in vitamin D deficient patients compared to those who had higher vitamin D levels (3.7 ± 0.9 vs 4.1 ± 0.7 g/dl, p = 0.018)but there was no significant difference in baseline proteinuria and eGFR. Crescentic lesions were more frequent in vitamin D deficient group (19.5% vs 6.3%, p = 0.022). At median follow up of 21.5 months (6 – 56 months), there was no difference in remission (68.3% vs 65.6%, p = 0.777) and disease progression (12.5% vs 9.4%, p = 0.614) in those with and without Vitamin D deficiency respectively. On multivariate cox proportional hazard analysis, vitamin D deficiency was not a significant risk factor for renal survival (HR-1.79, 95% confidence interval:0.50–6.34, p = 0.368). Conclusion There was no association between vitamin D deficiency and disease profile as well as renal outcome in Indian patients with IgAN..
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:24 |
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| Enthalten in: |
BMC Nephrology - 24(2023), 1, Seite 6 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Naba Farooqui [VerfasserIn] |
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| Links: |
doi.org [kostenfrei] |
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| Themen: |
25 (OH) vitamin D |
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| doi: |
10.1186/s12882-023-03061-0 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
DOAJ081655517 |
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| 520 | |a Abstract Background Vitamin D deficiency has been examined as a risk factor for severity and progression of kidney disease due to its immunomodulatory effects. There is paucity of data about its impact in IgA nephropathy (IgAN). Methods In a retrospective cohort study, 25 (OH) vitamin D assay was performed in bio-banked baseline serum samples collected during kidney biopsy of 105 adult patients with primary IgAN diagnosed between 2015 and 2019. A level of < 10 ng/mL was defined as Vitamin D deficiency. Results Mean age of patients was 34 ± 10.6 years, 69.5% were males. Mean baseline 25(OH) Vitamin D levels was 15.9 ± 11.9 ng/mL and 41(39%) patients had vitamin D deficiency. Serum albumin level was lower in vitamin D deficient patients compared to those who had higher vitamin D levels (3.7 ± 0.9 vs 4.1 ± 0.7 g/dl, p = 0.018)but there was no significant difference in baseline proteinuria and eGFR. Crescentic lesions were more frequent in vitamin D deficient group (19.5% vs 6.3%, p = 0.022). At median follow up of 21.5 months (6 – 56 months), there was no difference in remission (68.3% vs 65.6%, p = 0.777) and disease progression (12.5% vs 9.4%, p = 0.614) in those with and without Vitamin D deficiency respectively. On multivariate cox proportional hazard analysis, vitamin D deficiency was not a significant risk factor for renal survival (HR-1.79, 95% confidence interval:0.50–6.34, p = 0.368). Conclusion There was no association between vitamin D deficiency and disease profile as well as renal outcome in Indian patients with IgAN. | ||
| 650 | 4 | |a 25 (OH) vitamin D | |
| 650 | 4 | |a IgA nephropathy | |
| 650 | 4 | |a Outcome | |
| 653 | 0 | |a Diseases of the genitourinary system. Urology | |
| 700 | 0 | |a Arunkumar Subbiah |e verfasserin |4 aut | |
| 700 | 0 | |a Pradeep Chaturvedi |e verfasserin |4 aut | |
| 700 | 0 | |a Hem Sati |e verfasserin |4 aut | |
| 700 | 0 | |a Geetika Singh |e verfasserin |4 aut | |
| 700 | 0 | |a Dipankar Bhowmik |e verfasserin |4 aut | |
| 700 | 0 | |a Sanjay K. Agarwal |e verfasserin |4 aut | |
| 700 | 0 | |a Soumita Bagchi |e verfasserin |4 aut | |
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