Hepatitis C Virus Micro-Elimination Plan in Southern Italy: The “HCV ICEberg” Project
This study evaluates the feasibility of a local action program for HCV micro-elimination in highly endemic areas. Retrospective analysis: administrative and laboratory data (Local Health Unit, southern Italy) were integrated to quantize the anti-HCV-positive subjects not RNA tested and untreated HCV-infected subjects (2018–2022). Prospective analysis: all subjects admitted to a division of the LHU largest hospital (2021–2022) were tested for HCV, with linkage of active-infected patients to care. Overall, 49287 subjects were HCV-Ab tested: 1071 (2.2%) resulted positive without information for an HCV RNA test and 230 (0.5%) had an active infection not yet cured. Among 856 admitted subjects, 54 (6.3%) were HCV-Ab+ and 27 (3.0%) HCV RNA+. Of HCV-infected patients, 22.2% had advanced liver disease, highlighting the need for earlier diagnosis; 27.7% were unaware of HCV infection; and 20.4% were previously aware but never referred to a clinical center. Of these, 26% died and 74% received treatment. Our study emphasizes the value of an active HCV hospital case-finding program to enhance diagnosis in patients with several comorbidities and to easily link them to care. Our data strongly suggest extending this program to all hospital wards/access as a standard of care, particularly in highly endemic areas, to help HCV disease control and take steps in achieving the elimination goals..
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2023 |
---|---|
Erschienen: |
2023 |
Enthalten in: |
Zur Gesamtaufnahme - volume:12 |
---|---|
Enthalten in: |
Pathogens - 12(2023), 2, p 195 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Carmine Coppola [VerfasserIn] |
---|
Links: |
doi.org [kostenfrei] |
---|
Themen: |
Administrative data |
---|
doi: |
10.3390/pathogens12020195 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
DOAJ080007643 |
---|
LEADER | 01000caa a22002652 4500 | ||
---|---|---|---|
001 | DOAJ080007643 | ||
003 | DE-627 | ||
005 | 20240413061820.0 | ||
007 | cr uuu---uuuuu | ||
008 | 230310s2023 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.3390/pathogens12020195 |2 doi | |
035 | |a (DE-627)DOAJ080007643 | ||
035 | |a (DE-599)DOAJ77824082374341c38499ea0ba877a539 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 0 | |a Carmine Coppola |e verfasserin |4 aut | |
245 | 1 | 0 | |a Hepatitis C Virus Micro-Elimination Plan in Southern Italy: The “HCV ICEberg” Project |
264 | 1 | |c 2023 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a Computermedien |b c |2 rdamedia | ||
338 | |a Online-Ressource |b cr |2 rdacarrier | ||
520 | |a This study evaluates the feasibility of a local action program for HCV micro-elimination in highly endemic areas. Retrospective analysis: administrative and laboratory data (Local Health Unit, southern Italy) were integrated to quantize the anti-HCV-positive subjects not RNA tested and untreated HCV-infected subjects (2018–2022). Prospective analysis: all subjects admitted to a division of the LHU largest hospital (2021–2022) were tested for HCV, with linkage of active-infected patients to care. Overall, 49287 subjects were HCV-Ab tested: 1071 (2.2%) resulted positive without information for an HCV RNA test and 230 (0.5%) had an active infection not yet cured. Among 856 admitted subjects, 54 (6.3%) were HCV-Ab+ and 27 (3.0%) HCV RNA+. Of HCV-infected patients, 22.2% had advanced liver disease, highlighting the need for earlier diagnosis; 27.7% were unaware of HCV infection; and 20.4% were previously aware but never referred to a clinical center. Of these, 26% died and 74% received treatment. Our study emphasizes the value of an active HCV hospital case-finding program to enhance diagnosis in patients with several comorbidities and to easily link them to care. Our data strongly suggest extending this program to all hospital wards/access as a standard of care, particularly in highly endemic areas, to help HCV disease control and take steps in achieving the elimination goals. | ||
650 | 4 | |a administrative data | |
650 | 4 | |a cascade of care | |
650 | 4 | |a opportunistic screening | |
650 | 4 | |a linkage to care | |
650 | 4 | |a HCV micro-elimination | |
653 | 0 | |a Medicine | |
653 | 0 | |a R | |
700 | 0 | |a Loreta A. Kondili |e verfasserin |4 aut | |
700 | 0 | |a Laura Staiano |e verfasserin |4 aut | |
700 | 0 | |a Simona Cammarota |e verfasserin |4 aut | |
700 | 0 | |a Anna Citarella |e verfasserin |4 aut | |
700 | 0 | |a Mirko Pio Aloisio |e verfasserin |4 aut | |
700 | 0 | |a Angelo Annunziata |e verfasserin |4 aut | |
700 | 0 | |a Francesca Futura Bernardi |e verfasserin |4 aut | |
700 | 0 | |a Aldo D’Avino |e verfasserin |4 aut | |
700 | 0 | |a Michele D’Orazio |e verfasserin |4 aut | |
700 | 0 | |a Marianna Fogliasecca |e verfasserin |4 aut | |
700 | 0 | |a Mario Fusco |e verfasserin |4 aut | |
700 | 0 | |a Federica Pisano |e verfasserin |4 aut | |
700 | 0 | |a Adriano Vercellone |e verfasserin |4 aut | |
700 | 0 | |a Elvira Bianco |e verfasserin |4 aut | |
700 | 0 | |a Ugo Trama |e verfasserin |4 aut | |
773 | 0 | 8 | |i In |t Pathogens |d MDPI AG, 2012 |g 12(2023), 2, p 195 |w (DE-627)DOAJ000006726 |x 20760817 |7 nnns |
773 | 1 | 8 | |g volume:12 |g year:2023 |g number:2, p 195 |
856 | 4 | 0 | |u https://doi.org/10.3390/pathogens12020195 |z kostenfrei |
856 | 4 | 0 | |u https://doaj.org/article/77824082374341c38499ea0ba877a539 |z kostenfrei |
856 | 4 | 0 | |u https://www.mdpi.com/2076-0817/12/2/195 |z kostenfrei |
856 | 4 | 2 | |u https://doaj.org/toc/2076-0817 |y Journal toc |z kostenfrei |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_DOAJ | ||
951 | |a AR | ||
952 | |d 12 |j 2023 |e 2, p 195 |