Outlook of IL-6 signaling blockade for COVID-19 pneumonia
Abstract In this review article, it is highlighted the implications of pleiotropic functions of interleukin-6 (IL-6) for one of the therapeutic options targeting for COVID-19. Moreover, it is discussed how real-world data and trials with IL-6 signaling blockade will be crucial in informing the development of new treatment for COVID-19 pneumonia. Given physiological roles of IL-6 in inflammatory conditions and the data from real world, IL-6 signal inhibitors, along with standard of care (SOC) treatment, might provide efficacy, offering the potential to treat COVID-19 in hospitalized populations more effectively than current SOC alone. Therefore, on-going and planned randomized placebo-controlled studies in combination with SOC and other therapeutics to assess safety and efficacy of IL-6 signal inhibitors in hospitalized patients with severe COVID-19 pneumonia will be warranted to address the high unmet need and burden of disease in this severely ill population..
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2020 |
|---|---|
| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:40 |
|---|---|
| Enthalten in: |
Inflammation and Regeneration - 40(2020), 1, Seite 8 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Misato Hashizume [VerfasserIn] |
|---|
| Links: |
doi.org [kostenfrei] |
|---|
| Themen: |
COVID-19 pneumonia |
|---|
| doi: |
10.1186/s41232-020-00134-7 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
DOAJ076127818 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | DOAJ076127818 | ||
| 003 | DE-627 | ||
| 005 | 20230309141726.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 230228s2020 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1186/s41232-020-00134-7 |2 doi | |
| 035 | |a (DE-627)DOAJ076127818 | ||
| 035 | |a (DE-599)DOAJ129ea98e3e404292a4584dcde5db4e94 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 050 | 0 | |a RB1-214 | |
| 100 | 0 | |a Misato Hashizume |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Outlook of IL-6 signaling blockade for COVID-19 pneumonia |
| 264 | 1 | |c 2020 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 520 | |a Abstract In this review article, it is highlighted the implications of pleiotropic functions of interleukin-6 (IL-6) for one of the therapeutic options targeting for COVID-19. Moreover, it is discussed how real-world data and trials with IL-6 signaling blockade will be crucial in informing the development of new treatment for COVID-19 pneumonia. Given physiological roles of IL-6 in inflammatory conditions and the data from real world, IL-6 signal inhibitors, along with standard of care (SOC) treatment, might provide efficacy, offering the potential to treat COVID-19 in hospitalized populations more effectively than current SOC alone. Therefore, on-going and planned randomized placebo-controlled studies in combination with SOC and other therapeutics to assess safety and efficacy of IL-6 signal inhibitors in hospitalized patients with severe COVID-19 pneumonia will be warranted to address the high unmet need and burden of disease in this severely ill population. | ||
| 650 | 4 | |a Interleukin-6 | |
| 650 | 4 | |a COVID-19 pneumonia | |
| 650 | 4 | |a Cytokine release syndrome | |
| 650 | 4 | |a Tocilizumab | |
| 650 | 4 | |a Sarilumab | |
| 650 | 4 | |a Siltuximab | |
| 653 | 0 | |a Pathology | |
| 773 | 0 | 8 | |i In |t Inflammation and Regeneration |d BMC, 2016 |g 40(2020), 1, Seite 8 |w (DE-627)DOAJ00013371X |x 18808190 |7 nnns |
| 773 | 1 | 8 | |g volume:40 |g year:2020 |g number:1 |g pages:8 |
| 856 | 4 | 0 | |u https://doi.org/10.1186/s41232-020-00134-7 |z kostenfrei |
| 856 | 4 | 0 | |u https://doaj.org/article/129ea98e3e404292a4584dcde5db4e94 |z kostenfrei |
| 856 | 4 | 0 | |u http://link.springer.com/article/10.1186/s41232-020-00134-7 |z kostenfrei |
| 856 | 4 | 2 | |u https://doaj.org/toc/1880-8190 |y Journal toc |z kostenfrei |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_DOAJ | ||
| 951 | |a AR | ||
| 952 | |d 40 |j 2020 |e 1 |h 8 | ||