Evaluation of Antibody Levels in Patients with COVID-19
Objective: Severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) disease (COVID-19) is still showing its effect as a major problem all over the world. Currently, antibody responses to SARS-CoV-2 are not fully understood, and the clinical benefits of serological testing are uncertain. In this study, antibody levels of patients with COVID-19 were evaluated with Roche SARS-CoV-2 antibody test in samples taken at different times. Method: SARS-CoV-2 PCR tests of 21 people were examined in our hospital between March 2020 and April 2020, and serum samples were collected again in July 2020 and Roche SARS-CoV-2 antibody levels were measured in a total of 42 samples. Results: Anti SARS CoV 2 antibodies were found to be negative in 7 of the first samples of 21 people and Anti SARS CoV 2 antibodies were found to be positive in 14 of them. RT-PCR results were found to be positive in all of these 7 negative samples. Anti-SARS-CoV-2 antibodies were found to be negative in 1 of the second samples, and Anti-SARS-CoV-2 antibodies were found to be positive in 20 of them. Considering the second samples of all subjects, no decrease was detected in the SARS-CoV-2 antibody values in any sample. Conclusions: In the study, there are samples with negative antibody levels and partially low cut off index values even in the second samples. This study is important in terms of both the presence and follow-up of antibody levels and detection of donor antibody levels in plasmapheresis..
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:48 |
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| Enthalten in: |
Dicle Medical Journal - 48(2021), 1, Seite 181-186 |
| Sprache: |
Englisch ; Türkisch |
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| Beteiligte Personen: |
Özgür Aslan [VerfasserIn] |
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| Links: |
doi.org [kostenfrei] |
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| Themen: |
Diagnostic tests. |
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| doi: |
10.5798/dicletip.887689 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
DOAJ070061254 |
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| 520 | |a Objective: Severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) disease (COVID-19) is still showing its effect as a major problem all over the world. Currently, antibody responses to SARS-CoV-2 are not fully understood, and the clinical benefits of serological testing are uncertain. In this study, antibody levels of patients with COVID-19 were evaluated with Roche SARS-CoV-2 antibody test in samples taken at different times. Method: SARS-CoV-2 PCR tests of 21 people were examined in our hospital between March 2020 and April 2020, and serum samples were collected again in July 2020 and Roche SARS-CoV-2 antibody levels were measured in a total of 42 samples. Results: Anti SARS CoV 2 antibodies were found to be negative in 7 of the first samples of 21 people and Anti SARS CoV 2 antibodies were found to be positive in 14 of them. RT-PCR results were found to be positive in all of these 7 negative samples. Anti-SARS-CoV-2 antibodies were found to be negative in 1 of the second samples, and Anti-SARS-CoV-2 antibodies were found to be positive in 20 of them. Considering the second samples of all subjects, no decrease was detected in the SARS-CoV-2 antibody values in any sample. Conclusions: In the study, there are samples with negative antibody levels and partially low cut off index values even in the second samples. This study is important in terms of both the presence and follow-up of antibody levels and detection of donor antibody levels in plasmapheresis. | ||
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