Multi-System Inflammatory Syndrome in Children (MIS-C) Following SARS-CoV-2 Infection: Review of Clinical Presentation, Hypothetical Pathogenesis, and Proposed Management

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection may result in the multisystem inflammatory syndrome in children (MIS-C). The clinical presentation of MIS-C includes fever, severe illness, and the involvement of two or more organ systems, in combination with laboratory evidence of inflammation and laboratory or epidemiologic evidence of SARS-CoV-2 infection. Some features of MIS-C resemble Kawasaki Disease, toxic shock syndrome, and secondary hemophagocytic lymphohistiocytosis/macrophage activation syndrome. The relationship of MIS-C to SARS-CoV-2 infection suggests that the pathogenesis involves post-infectious immune dysregulation. Patients with MIS-C should ideally be managed in a pediatric intensive care environment since rapid clinical deterioration may occur. Specific immunomodulatory therapy depends on the clinical presentation. The relationship between the immune response to SARS-CoV-2 vaccines in development and MIS-C requires further study..

Medienart:

E-Artikel

Erscheinungsjahr:

2020

Erschienen:

2020

Enthalten in:

Zur Gesamtaufnahme - volume:7

Enthalten in:

Children - 7(2020), 7, p 69

Sprache:

Englisch

Beteiligte Personen:

Natasha A. Nakra [VerfasserIn]
Dean A. Blumberg [VerfasserIn]
Angel Herrera-Guerra [VerfasserIn]
Satyan Lakshminrusimha [VerfasserIn]

Links:

doi.org [kostenfrei]
doaj.org [kostenfrei]
www.mdpi.com [kostenfrei]
Journal toc [kostenfrei]

Themen:

COVID-19
Hemophagocytic lymphohistiocytosis
Kawasaki Disease
Multisystem inflammatory syndrome in children (MIS-C)
Pediatrics
SARS-CoV-2
Toxic shock syndrome

doi:

10.3390/children7070069

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

DOAJ061921149