Prognostic nutritional index predicts mortality in infective endocarditis
Objective: The prognostic nutritional index (PNI), based on serum albumin and lymphocyte concentration, is an inflammation-based nutritional score that has been shown to be a prognostic determinant in several populations. The aim of this study was to investigate the impact of PNI on mortality in patients with infective endocarditis (IE). Methods: A total of 131 patients with IE were enrolled in this retrospective study. The patients were divided into 2 groups based on in-hospital mortality. The PNI value of the patients was evaluated, as well as baseline clinical and demographical variables. Results: Among the study group, 29 patients died in-hospital during the median follow-up of 37 days. The PNI was found to be lower in cases of mortality (35.90+-6.96; 31.09+-5.88; p=0.001). ROC curve analysis also demonstrated that the PNI had a good predictive value for in-hospital mortality with a cut-off value of 35.6 (Area under the curve: 0.691; 95% confidence interval [CI]: 0.589–0.794; p=0.002). In multivariate logistic regression analysis, advanced age (Odds ratio [OR]: 1.078; 95% CI: 1.017–1.143; p=0.012), PNI (OR: 0.911; 95% CI: 0.835–0.993; p=0.034), and leaflet perforation (OR: 5.557; 95% CI: 1.357–22.765; p=0.017) were found to be independent predictors of mortality. Kaplan-Meier survival analysis revealed that long-term survival was found to be significantly decreased in patients with a lower PNI (Log rank: p=0.008). Conclusion: The PNI result was associated with an increased in-hospital mortality rate in patients with IE. The PNI value, advanced age, and cardiac valve perforation as a complication of IE were found to be independent predictors of mortality..
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:48 |
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| Enthalten in: |
Türk Kardiyoloji Derneği Arşivi - 48(2020), 4, Seite 392-402 |
| Sprache: |
Englisch ; Türkisch |
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| Beteiligte Personen: |
Serkan Kahraman [VerfasserIn] |
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| Links: |
doi.org [kostenfrei] |
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| Themen: |
Albumin |
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| doi: |
10.5543/tkda.2020.25899 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
DOAJ059125004 |
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| 520 | |a Objective: The prognostic nutritional index (PNI), based on serum albumin and lymphocyte concentration, is an inflammation-based nutritional score that has been shown to be a prognostic determinant in several populations. The aim of this study was to investigate the impact of PNI on mortality in patients with infective endocarditis (IE). Methods: A total of 131 patients with IE were enrolled in this retrospective study. The patients were divided into 2 groups based on in-hospital mortality. The PNI value of the patients was evaluated, as well as baseline clinical and demographical variables. Results: Among the study group, 29 patients died in-hospital during the median follow-up of 37 days. The PNI was found to be lower in cases of mortality (35.90+-6.96; 31.09+-5.88; p=0.001). ROC curve analysis also demonstrated that the PNI had a good predictive value for in-hospital mortality with a cut-off value of 35.6 (Area under the curve: 0.691; 95% confidence interval [CI]: 0.589–0.794; p=0.002). In multivariate logistic regression analysis, advanced age (Odds ratio [OR]: 1.078; 95% CI: 1.017–1.143; p=0.012), PNI (OR: 0.911; 95% CI: 0.835–0.993; p=0.034), and leaflet perforation (OR: 5.557; 95% CI: 1.357–22.765; p=0.017) were found to be independent predictors of mortality. Kaplan-Meier survival analysis revealed that long-term survival was found to be significantly decreased in patients with a lower PNI (Log rank: p=0.008). Conclusion: The PNI result was associated with an increased in-hospital mortality rate in patients with IE. The PNI value, advanced age, and cardiac valve perforation as a complication of IE were found to be independent predictors of mortality. | ||
| 650 | 4 | |a albumin | |
| 650 | 4 | |a infective endocarditis; in-hospital mortality; lymphocyte; prognosis; prognostic nutritional index. | |
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| 653 | 0 | |a Internal medicine | |
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| 700 | 0 | |a Fatih Uzun |e verfasserin |4 aut | |
| 700 | 0 | |a Mehmet Ertürk |e verfasserin |4 aut | |
| 700 | 0 | |a Mehmet Emin Kalkan |e verfasserin |4 aut | |
| 700 | 0 | |a Mustafa Yıldız |e verfasserin |4 aut | |
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