Study of surfactants influence on the noopept releasing from the nasal dosage form
The nasal route of drug administration, as is well known, is characterized by some advantages: absorption rate and rapid onset of therapeutic effect, availability of drug delivery without hepatic first-pass elimination, it is suitable and easily accessible. Earlier a medication for nasal administration with noopept – a low toxic substance with peptide nature without any side effects and high activity has been developed. After advance investigations, a solution of sodium carboxymethylcellulose providing the highest rate of noopept releasing was chosen as a delivery base. The aim of work the study of surfactants' influence on the noopept releasing from the nasal dosage form. Materials and methods. For the investigation, the compositions containing twin-80 from 0 % to 3 % were prepared. Surfactant was added to the nasal dosage form containing noonpept 1 %, glycerol, and bishofit poltavsky equally by 5 % and solution of sodium carboxymethylcellulose. Noopept releasing was studied using the method of equilibrium dialysis by Kruvchinsky through the semipermeable membrane – cellophane film “Kuprofan” after 30 minutes. Noopept concentration was determined by the UV-spectrophotometry at 258 nm. Results. Results of investigation have verified that the addition of twin-80 to nasal dosage form with noopept provides with a better level of releasing of the active substance. At the same time, increasing of concentration more than 1 % hasn’t a significant influence on the noopept releasing. Conclusions. It was determined that the content of twin-80 has a significant influence on a noopept releasing from the nasal dosage forms. The concentration of twin-80 1 % provides optimal releasing..
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2020 |
|---|---|
| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:13 |
|---|---|
| Enthalten in: |
Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki - 13(2020), 1, Seite 105-108 |
| Sprache: |
Englisch ; Russisch ; Ukrainisch |
|---|
| Beteiligte Personen: |
B. S. Burlaka [VerfasserIn] |
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| Links: |
doi.org [kostenfrei] |
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| Themen: |
Nasal dosage form |
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| doi: |
10.14739/2409-2932.2020.1.198183 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
DOAJ057787239 |
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| 520 | |a The nasal route of drug administration, as is well known, is characterized by some advantages: absorption rate and rapid onset of therapeutic effect, availability of drug delivery without hepatic first-pass elimination, it is suitable and easily accessible. Earlier a medication for nasal administration with noopept – a low toxic substance with peptide nature without any side effects and high activity has been developed. After advance investigations, a solution of sodium carboxymethylcellulose providing the highest rate of noopept releasing was chosen as a delivery base. The aim of work the study of surfactants' influence on the noopept releasing from the nasal dosage form. Materials and methods. For the investigation, the compositions containing twin-80 from 0 % to 3 % were prepared. Surfactant was added to the nasal dosage form containing noonpept 1 %, glycerol, and bishofit poltavsky equally by 5 % and solution of sodium carboxymethylcellulose. Noopept releasing was studied using the method of equilibrium dialysis by Kruvchinsky through the semipermeable membrane – cellophane film “Kuprofan” after 30 minutes. Noopept concentration was determined by the UV-spectrophotometry at 258 nm. Results. Results of investigation have verified that the addition of twin-80 to nasal dosage form with noopept provides with a better level of releasing of the active substance. At the same time, increasing of concentration more than 1 % hasn’t a significant influence on the noopept releasing. Conclusions. It was determined that the content of twin-80 has a significant influence on a noopept releasing from the nasal dosage forms. The concentration of twin-80 1 % provides optimal releasing. | ||
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