Low vitamin D status is associated with coronavirus disease 2019 outcomes: a systematic review and meta-analysis
Background: Observational studies suggest that the risk and clinical prognosis of coronavirus disease 2019 (COVID-19) are related to low vitamin D status; however, the data are inconsistent. Objectives: We conducted a systematic review and meta-analysis to assess the association between low vitamin D status and COVID-19. Methods: A systematic search was conducted with PubMed, Embase, and the Cochrane Library from database inception to September 25, 2020. The standardized mean difference (SMD) or odds ratio (OR) and corresponding 95% confidence interval (CI) was applied to estimate pooled results. Random - or fixed-effect models based on heterogeneity were used for the meta-analysis. Funnel plots and Egger regression tests were used to assess publication bias. Results: A total of ten articles with 361,934 participants were selected for meta-analysis. Overall, the pooled OR in the fixed-effect model showed that vitamin D deficiency or insufficiency was associated with an increased risk of COVID-19 (OR = 1.43, 95% CI 1.00–2.05). In addition, COVID-19-positive individuals had lower vitamin D levels than COVID-19-negative individuals (SMD = -0.37, 95% CI = -0.52 to -0.21). Significant heterogeneity existed in both endpoints. Funnel plots and Egger regression tests revealed significant publication bias. Conclusions: This systematic review and meta-analysis indicated that low vitamin D status might be associated with an increased risk of COVID-19 infection. Further studies are needed to evaluate the impact of vitamin D supplementation on the clinical severity and prognosis in patients with COVID-19. Systematic Review Registration: PROSPERO registration no: CRD42020216740..
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2021 |
|---|---|
| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:104 |
|---|---|
| Enthalten in: |
International Journal of Infectious Diseases - 104(2021), Seite 58-64 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Nanyang Liu [VerfasserIn] |
|---|
| Links: |
doi.org [kostenfrei] |
|---|
| Themen: |
25-hydroxyvitamin D |
|---|
| doi: |
10.1016/j.ijid.2020.12.077 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
DOAJ056751192 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | DOAJ056751192 | ||
| 003 | DE-627 | ||
| 005 | 20230502132713.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 230227s2021 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.ijid.2020.12.077 |2 doi | |
| 035 | |a (DE-627)DOAJ056751192 | ||
| 035 | |a (DE-599)DOAJ04d5600256594d11b4e7eeb2aead98c7 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 050 | 0 | |a RC109-216 | |
| 100 | 0 | |a Nanyang Liu |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Low vitamin D status is associated with coronavirus disease 2019 outcomes: a systematic review and meta-analysis |
| 264 | 1 | |c 2021 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 520 | |a Background: Observational studies suggest that the risk and clinical prognosis of coronavirus disease 2019 (COVID-19) are related to low vitamin D status; however, the data are inconsistent. Objectives: We conducted a systematic review and meta-analysis to assess the association between low vitamin D status and COVID-19. Methods: A systematic search was conducted with PubMed, Embase, and the Cochrane Library from database inception to September 25, 2020. The standardized mean difference (SMD) or odds ratio (OR) and corresponding 95% confidence interval (CI) was applied to estimate pooled results. Random - or fixed-effect models based on heterogeneity were used for the meta-analysis. Funnel plots and Egger regression tests were used to assess publication bias. Results: A total of ten articles with 361,934 participants were selected for meta-analysis. Overall, the pooled OR in the fixed-effect model showed that vitamin D deficiency or insufficiency was associated with an increased risk of COVID-19 (OR = 1.43, 95% CI 1.00–2.05). In addition, COVID-19-positive individuals had lower vitamin D levels than COVID-19-negative individuals (SMD = -0.37, 95% CI = -0.52 to -0.21). Significant heterogeneity existed in both endpoints. Funnel plots and Egger regression tests revealed significant publication bias. Conclusions: This systematic review and meta-analysis indicated that low vitamin D status might be associated with an increased risk of COVID-19 infection. Further studies are needed to evaluate the impact of vitamin D supplementation on the clinical severity and prognosis in patients with COVID-19. Systematic Review Registration: PROSPERO registration no: CRD42020216740. | ||
| 650 | 4 | |a Coronavirus disease 2019 | |
| 650 | 4 | |a Vitamin D | |
| 650 | 4 | |a Meta-analysis | |
| 650 | 4 | |a Low vitamin D status | |
| 650 | 4 | |a 25-hydroxyvitamin D | |
| 653 | 0 | |a Infectious and parasitic diseases | |
| 700 | 0 | |a Jiahui Sun |e verfasserin |4 aut | |
| 700 | 0 | |a Xiyuan Wang |e verfasserin |4 aut | |
| 700 | 0 | |a Tingting Zhang |e verfasserin |4 aut | |
| 700 | 0 | |a Ming Zhao |e verfasserin |4 aut | |
| 700 | 0 | |a Hao Li |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i In |t International Journal of Infectious Diseases |d Elsevier, 2015 |g 104(2021), Seite 58-64 |w (DE-627)DOAJ000043923 |x 18783511 |7 nnns |
| 773 | 1 | 8 | |g volume:104 |g year:2021 |g pages:58-64 |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.ijid.2020.12.077 |z kostenfrei |
| 856 | 4 | 0 | |u https://doaj.org/article/04d5600256594d11b4e7eeb2aead98c7 |z kostenfrei |
| 856 | 4 | 0 | |u http://www.sciencedirect.com/science/article/pii/S120197122032600X |z kostenfrei |
| 856 | 4 | 2 | |u https://doaj.org/toc/1201-9712 |y Journal toc |z kostenfrei |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_DOAJ | ||
| 912 | |a SSG-OLC-PHA | ||
| 951 | |a AR | ||
| 952 | |d 104 |j 2021 |h 58-64 | ||