Different pattern of the second outbreak of COVID-19 in Marseille, France
Objective: To describe the characteristics of COVID-19 patients seen in March-April and June-August 2020 in Marseille, France with the aim to investigate possible changes in the disease between these two time periods. Methods: Demographics, hospitalization rate, transfer to intensive care unit (ICU), lethality, clinical and biological parameters were investigated. Results: Compared to those seen in March-April, COVID-19 patients seen in June-August were significantly younger (39.2 vs. 45.3 years), more likely to be male (52.9% vs. 45.6%), and less likely to be hospitalized (10.7 vs. 18.0%), to be transferred to ICU (0.9% vs. 1.8%) and to die (0.1% vs. 1.1%). Their mean fibrinogen and D-dimer blood levels were lower (1.0 vs. 1.5 g/L and 0.6 vs. 1.1 μg/mL, respectively). By contrast, their viral load was higher (cycle threshold ≤16 = 5.1% vs. 3.7%). Conclusions: Patients in the two periods did not present marked age and sex differences, but markers of severity were undoubtedly less prevalent in the summer period, associating with a 10 times decrease in the lethality rate..
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:102 |
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| Enthalten in: |
International Journal of Infectious Diseases - 102(2021), Seite 17-19 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Philippe Gautret [VerfasserIn] |
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| Links: |
doi.org [kostenfrei] |
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| Themen: |
COVID-19 |
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| doi: |
10.1016/j.ijid.2020.10.005 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
DOAJ055485545 |
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| 520 | |a Objective: To describe the characteristics of COVID-19 patients seen in March-April and June-August 2020 in Marseille, France with the aim to investigate possible changes in the disease between these two time periods. Methods: Demographics, hospitalization rate, transfer to intensive care unit (ICU), lethality, clinical and biological parameters were investigated. Results: Compared to those seen in March-April, COVID-19 patients seen in June-August were significantly younger (39.2 vs. 45.3 years), more likely to be male (52.9% vs. 45.6%), and less likely to be hospitalized (10.7 vs. 18.0%), to be transferred to ICU (0.9% vs. 1.8%) and to die (0.1% vs. 1.1%). Their mean fibrinogen and D-dimer blood levels were lower (1.0 vs. 1.5 g/L and 0.6 vs. 1.1 μg/mL, respectively). By contrast, their viral load was higher (cycle threshold ≤16 = 5.1% vs. 3.7%). Conclusions: Patients in the two periods did not present marked age and sex differences, but markers of severity were undoubtedly less prevalent in the summer period, associating with a 10 times decrease in the lethality rate. | ||
| 650 | 4 | |a COVID-19 | |
| 650 | 4 | |a Seasonality | |
| 650 | 4 | |a Severity markers | |
| 650 | 4 | |a Lethality | |
| 653 | 0 | |a Infectious and parasitic diseases | |
| 700 | 0 | |a Philippe Colson |e verfasserin |4 aut | |
| 700 | 0 | |a Jean Christophe Lagier |e verfasserin |4 aut | |
| 700 | 0 | |a Laurence Camoin-Jau |e verfasserin |4 aut | |
| 700 | 0 | |a Audrey Giraud-Gatineau |e verfasserin |4 aut | |
| 700 | 0 | |a Sophia Boudjema |e verfasserin |4 aut | |
| 700 | 0 | |a Julie Finance |e verfasserin |4 aut | |
| 700 | 0 | |a Hervé Chaudet |e verfasserin |4 aut | |
| 700 | 0 | |a Didier Raoult |e verfasserin |4 aut | |
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