Temporal and age distributions of SARS-CoV-2 and other coronaviruses, southeastern France
Objectives: The SARS-CoV-2 epidemic presents a poorly understood epidemiological cycle. We aimed to compare the age and weekly distributions of the five human coronaviruses, including SARS-CoV-2, that circulated in southeastern France. Methods: We analyzed all available diagnoses of respiratory viruses, including SARS-CoV-2, performed between 09/2013 and 05/2020 at the University Hospital Institute Méditerranée Infection in Marseille, southeastern France. Results: For SARS-CoV-2, positive children <15 years of age represented 3.4% (228/6,735) of all positive cases, which is significantly less than for endemic coronaviruses (46.1%; 533/1,156; p < 0.001). Among 10,026 patients tested for SARS-CoV-2 and endemic coronaviruses in 2020, children <15 years represented a significantly lower proportion of all positive cases for SARS-CoV-2 than for endemic coronaviruses [2.2% (24/1,067) vs. 33.5% (149/445), respectively; p < 0.001]. Epidemic curves for endemic coronaviruses and SARS-CoV-2 in 91,722 patients showed comparable bell-shaped distributions with a slight time lag. In contrast, the age distribution of endemic coronaviruses and 14 other respiratory viruses differed significantly compared to that of SARS-CoV-2, which was the only virus to relatively spare children. Conclusions: We observed for SARS-CoV-2 a temporal distribution resembling that of endemic coronaviruses but an age distribution that relatively spares the youngest subjects, who are those the most exposed to endemic coronaviruses..
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:101 |
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| Enthalten in: |
International Journal of Infectious Diseases - 101(2020), Seite 121-125 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Philippe Colson [VerfasserIn] |
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| Links: |
doi.org [kostenfrei] |
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| Themen: |
Age |
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| doi: |
10.1016/j.ijid.2020.09.1417 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
DOAJ054889952 |
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| 245 | 1 | 0 | |a Temporal and age distributions of SARS-CoV-2 and other coronaviruses, southeastern France |
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| 520 | |a Objectives: The SARS-CoV-2 epidemic presents a poorly understood epidemiological cycle. We aimed to compare the age and weekly distributions of the five human coronaviruses, including SARS-CoV-2, that circulated in southeastern France. Methods: We analyzed all available diagnoses of respiratory viruses, including SARS-CoV-2, performed between 09/2013 and 05/2020 at the University Hospital Institute Méditerranée Infection in Marseille, southeastern France. Results: For SARS-CoV-2, positive children <15 years of age represented 3.4% (228/6,735) of all positive cases, which is significantly less than for endemic coronaviruses (46.1%; 533/1,156; p < 0.001). Among 10,026 patients tested for SARS-CoV-2 and endemic coronaviruses in 2020, children <15 years represented a significantly lower proportion of all positive cases for SARS-CoV-2 than for endemic coronaviruses [2.2% (24/1,067) vs. 33.5% (149/445), respectively; p < 0.001]. Epidemic curves for endemic coronaviruses and SARS-CoV-2 in 91,722 patients showed comparable bell-shaped distributions with a slight time lag. In contrast, the age distribution of endemic coronaviruses and 14 other respiratory viruses differed significantly compared to that of SARS-CoV-2, which was the only virus to relatively spare children. Conclusions: We observed for SARS-CoV-2 a temporal distribution resembling that of endemic coronaviruses but an age distribution that relatively spares the youngest subjects, who are those the most exposed to endemic coronaviruses. | ||
| 650 | 4 | |a SARS-CoV-2 | |
| 650 | 4 | |a Endemic coronavirus | |
| 650 | 4 | |a Age | |
| 650 | 4 | |a Children | |
| 650 | 4 | |a Cross-immunity | |
| 650 | 4 | |a Southeastern France | |
| 653 | 0 | |a Infectious and parasitic diseases | |
| 700 | 0 | |a Vera Esteves-Vieira |e verfasserin |4 aut | |
| 700 | 0 | |a Audrey Giraud-Gatineau |e verfasserin |4 aut | |
| 700 | 0 | |a Christine Zandotti |e verfasserin |4 aut | |
| 700 | 0 | |a Véronique Filosa |e verfasserin |4 aut | |
| 700 | 0 | |a Hervé Chaudet |e verfasserin |4 aut | |
| 700 | 0 | |a Jean-Christophe Lagier |e verfasserin |4 aut | |
| 700 | 0 | |a Didier Raoult |e verfasserin |4 aut | |
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