Prevalence of TLR-4 gene polymorphism in patients co-infected with HIV/HCV

<p<There was studied the prevalence of Asp299Gly polymorphism of TLR-4 gene in patients co-infected with HIV-HCV.</p<<p<<strong<Methods</strong<. To<strong< </strong<define the frequency of Asp299Gly polymorphism of TLR-4 gene there were examined 47 patients co-infected with HIV\HCV and 30 healthy donors by the method of polymorphism of the long restrictive fragments (PLRF) – polymerase chain reaction (PCR). Among examined persons there were 21 (44,7 %) women, 26 (55,3 %) – men. The mean age was 36,2±2,4 years, from 21 to52 years old.</p<<p class="21"<<strong<Results</strong<<strong<.</strong< The correlative analysis indicates the reverse dependency between Asp299Gly polymorphism of TLR-4 gene and Zn content (r=-0,34; p&lt;0,05), relative numder of CD4+,% (r=-0,32; p&lt;0,05) in blood serum of patients co-infected with HIV\HCV. At the same time in patients co-infected with HIV\HCV there was noticed the direct dependency between Asp299Gly polymorphism of TLR-4 gene and α tumor necrosis factor (r=0,32; p&lt;0,05), С-reactive protein (r=0,34; p&lt;0,05), absolute number of СD3+ Т-lymphocytes (r=0,34; p&lt;0,05), TG level (r=0,39; p&lt;0,02), absolute numder of CD45+ Т-lymphocyte (r=0,45; p&lt;0,001), insulin level (r=0,66; p&lt;0,001) and insulin-resistance (r=0,66; p&lt;0,001).</p<<p class="21"<<strong<Conclusions:</strong< In patients co-infected with HIV\HCV the Asp299Gly polymorphism of TLR-4 gene is reliably more often than the control group (χ<sup<2</sup<=4,5; р&lt;0,05). The correlative analysis demonstrated the powerful direct dependency between Asp299Gly polymorphism of TLR-4 gene and clinical stage of disease in patients co-infected with HIV\HCV (r=0,43; p&lt;0,001)</p<.

Medienart:	E-Artikel

Erscheinungsjahr:	2015
Erschienen:	2015

Enthalten in:	Zur Gesamtaufnahme - volume:11
Enthalten in:	ScienceRise - 11(2015), 3 (16), Seite 86-89

Sprache:	Englisch ; Russisch ; Ukrainisch

Beteiligte Personen:	Катерина Володимирівна Юрко [VerfasserIn]

Links:	doi.org [kostenfrei] doaj.org [kostenfrei] journals.uran.ua [kostenfrei] Journal toc [kostenfrei] Journal toc [kostenfrei]

Themen:	Cytokines HIV|HCV co-infection Insulin-resistance Lipid metabolism Metabolic disorders Science (General) Toll-like receptors

doi:	10.15587/2313-8416.2015.54495

funding:
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PPN (Katalog-ID):	DOAJ052240428