Serum cartilage biomarkers in late rheumatoid arthritis
Objectives: To evaluate the clinical value of two new cartilageserum markers in patients with rheumatoid arthritis of longduration. Methods: One hundred and forty patients followed for anaverage period of twelve years were evaluated for the presence ofhuman cartilage glycoprotein-39 and cartilage serum oligomericmatrix protein and the respective coefficient correlation betweenmarkers and disease activity score. Results: The mean values ofcartilage serum oligomeric matrix protein and human cartilageglycoprotein-39 were respectively 9 ± 6 ug/ml and 36 ± 16 mg/ml (p < 0,001) when compared to controls. A positive correlationwas observed between disease activity score and the cartilagebiomarkers (r = 0,67 for human cartilage glycoprotein-39 and r =0,83 for cartilage serum oligomeric matrix protein. Conclusion:This study shows in a inequivocal form that patientswith rheumatoid arthritis of long duration show higher values ofserum biochemical markers of cartilage metabolism and a positivecorrelation with disease activity score..
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2006 |
|---|---|
| Erschienen: |
2006 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:4 |
|---|---|
| Enthalten in: |
Einstein (São Paulo) - 4(2006), 1, Seite 3 |
| Sprache: |
Englisch ; Portugiesisch |
|---|
| Beteiligte Personen: |
Morton Aaron Scheinberg [VerfasserIn] |
|---|
| Links: |
doaj.org [kostenfrei] |
|---|
| Themen: |
Arthritis rheumatoid |
|---|
| Förderinstitution / Projekttitel: |
|
|---|
| PPN (Katalog-ID): |
DOAJ049781510 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | DOAJ049781510 | ||
| 003 | DE-627 | ||
| 005 | 20230308145145.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 230227s2006 xx |||||o 00| ||eng c | ||
| 035 | |a (DE-627)DOAJ049781510 | ||
| 035 | |a (DE-599)DOAJ69390340717c47dfb6c262cc08a1cbf9 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng |a por | ||
| 100 | 0 | |a Morton Aaron Scheinberg |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Serum cartilage biomarkers in late rheumatoid arthritis |
| 264 | 1 | |c 2006 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 520 | |a Objectives: To evaluate the clinical value of two new cartilageserum markers in patients with rheumatoid arthritis of longduration. Methods: One hundred and forty patients followed for anaverage period of twelve years were evaluated for the presence ofhuman cartilage glycoprotein-39 and cartilage serum oligomericmatrix protein and the respective coefficient correlation betweenmarkers and disease activity score. Results: The mean values ofcartilage serum oligomeric matrix protein and human cartilageglycoprotein-39 were respectively 9 ± 6 ug/ml and 36 ± 16 mg/ml (p < 0,001) when compared to controls. A positive correlationwas observed between disease activity score and the cartilagebiomarkers (r = 0,67 for human cartilage glycoprotein-39 and r =0,83 for cartilage serum oligomeric matrix protein. Conclusion:This study shows in a inequivocal form that patientswith rheumatoid arthritis of long duration show higher values ofserum biochemical markers of cartilage metabolism and a positivecorrelation with disease activity score. | ||
| 650 | 4 | |a Arthritis rheumatoid | |
| 650 | 4 | |a Biological makers/analysis | |
| 650 | 4 | |a Cartilage/metabolism | |
| 653 | 0 | |a Medicine | |
| 653 | 0 | |a R | |
| 700 | 0 | |a Geraldo da Rocha Castelar Pinheiro |e verfasserin |4 aut | |
| 700 | 0 | |a Carlos Augusto Ferreira de Andrade |e verfasserin |4 aut | |
| 700 | 0 | |a Marsen Garcia Pinto Coelho |e verfasserin |4 aut | |
| 700 | 0 | |a Sérgio Miranda Freire |e verfasserin |4 aut | |
| 700 | 0 | |a Sérgio Miranda Freire |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i In |t Einstein (São Paulo) |d Instituto Israelita de Ensino e Pesquisa Albert Einstein, 2017 |g 4(2006), 1, Seite 3 |w (DE-627)DOAJ000103438 |x 23176385 |7 nnns |
| 773 | 1 | 8 | |g volume:4 |g year:2006 |g number:1 |g pages:3 |
| 856 | 4 | 0 | |u https://doaj.org/article/69390340717c47dfb6c262cc08a1cbf9 |z kostenfrei |
| 856 | 4 | 0 | |u http://www.einstein.br/revista/arquivos/PDF/203-Vol4_N1_P1.pdf |z kostenfrei |
| 856 | 4 | 2 | |u https://doaj.org/toc/1679-4508 |y Journal toc |z kostenfrei |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_DOAJ | ||
| 951 | |a AR | ||
| 952 | |d 4 |j 2006 |e 1 |h 3 | ||