Association Between Drug Treatments and the Incidence of Liver Injury in Hospitalized Patients With COVID-19
The outbreak of coronavirus disease 2019 (COVID-19) has led to the emergence of global health care. In this study, we aimed to explore the association between drug treatments and the incidence of drug-induced liver injury (DILI) in hospitalized patients with COVID-19. A retrospective study was conducted on 5113 COVID-19 patients in Hubei province, among which 395 incurred liver injury. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated by Cox proportional hazards models. The results showed that COVID-19 patients who received antibiotics (HR 1.97, 95% CI: 1.55–2.51, p < 0.001), antifungal agents (HR 3.10, 95% CI: 1.93–4.99, p < 0.001) and corticosteroids (HR 2.31, 95% CI: 1.80–2.96, p < 0.001) had a higher risk of DILI compared to non-users. Special attention was given to the use of parenteral nutrition (HR 1.82, 95% CI: 1.31–2.52, p < 0.001) and enteral nutrition (HR 2.71, 95% CI: 1.98–3.71, p < 0.001), which were the risk factors for liver injury. In conclusion, this study suggests that the development of DILI in hospitalized patients with COVID-19 needs to be closely monitored, and the above-mentioned drug treatments may contribute to the risk of DILI..
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2022 |
---|---|
Erschienen: |
2022 |
Enthalten in: |
Zur Gesamtaufnahme - volume:13 |
---|---|
Enthalten in: |
Frontiers in Pharmacology - 13(2022) |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Suyu Gao [VerfasserIn] |
---|
Links: |
doi.org [kostenfrei] |
---|
Themen: |
COVID-19 |
---|
doi: |
10.3389/fphar.2022.799338 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
DOAJ049055658 |
---|
LEADER | 01000caa a22002652 4500 | ||
---|---|---|---|
001 | DOAJ049055658 | ||
003 | DE-627 | ||
005 | 20230308141312.0 | ||
007 | cr uuu---uuuuu | ||
008 | 230227s2022 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.3389/fphar.2022.799338 |2 doi | |
035 | |a (DE-627)DOAJ049055658 | ||
035 | |a (DE-599)DOAJf956ff3340d94fc980933175d84065a8 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
050 | 0 | |a RM1-950 | |
100 | 0 | |a Suyu Gao |e verfasserin |4 aut | |
245 | 1 | 0 | |a Association Between Drug Treatments and the Incidence of Liver Injury in Hospitalized Patients With COVID-19 |
264 | 1 | |c 2022 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a Computermedien |b c |2 rdamedia | ||
338 | |a Online-Ressource |b cr |2 rdacarrier | ||
520 | |a The outbreak of coronavirus disease 2019 (COVID-19) has led to the emergence of global health care. In this study, we aimed to explore the association between drug treatments and the incidence of drug-induced liver injury (DILI) in hospitalized patients with COVID-19. A retrospective study was conducted on 5113 COVID-19 patients in Hubei province, among which 395 incurred liver injury. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated by Cox proportional hazards models. The results showed that COVID-19 patients who received antibiotics (HR 1.97, 95% CI: 1.55–2.51, p < 0.001), antifungal agents (HR 3.10, 95% CI: 1.93–4.99, p < 0.001) and corticosteroids (HR 2.31, 95% CI: 1.80–2.96, p < 0.001) had a higher risk of DILI compared to non-users. Special attention was given to the use of parenteral nutrition (HR 1.82, 95% CI: 1.31–2.52, p < 0.001) and enteral nutrition (HR 2.71, 95% CI: 1.98–3.71, p < 0.001), which were the risk factors for liver injury. In conclusion, this study suggests that the development of DILI in hospitalized patients with COVID-19 needs to be closely monitored, and the above-mentioned drug treatments may contribute to the risk of DILI. | ||
650 | 4 | |a COVID-19 | |
650 | 4 | |a drug-induced liver injury (DILI) | |
650 | 4 | |a drug treatment | |
650 | 4 | |a risk factors | |
650 | 4 | |a multi-center retrospective study | |
653 | 0 | |a Therapeutics. Pharmacology | |
700 | 0 | |a Qingqing Yang |e verfasserin |4 aut | |
700 | 0 | |a Xuanxuan Wang |e verfasserin |4 aut | |
700 | 0 | |a Wen Hu |e verfasserin |4 aut | |
700 | 0 | |a Yun Lu |e verfasserin |4 aut | |
700 | 0 | |a Kun Yang |e verfasserin |4 aut | |
700 | 0 | |a Qiaoli Jiang |e verfasserin |4 aut | |
700 | 0 | |a Wenjing Li |e verfasserin |4 aut | |
700 | 0 | |a Haibo Song |e verfasserin |4 aut | |
700 | 0 | |a Haibo Song |e verfasserin |4 aut | |
700 | 0 | |a Feng Sun |e verfasserin |4 aut | |
700 | 0 | |a Hong Cheng |e verfasserin |4 aut | |
773 | 0 | 8 | |i In |t Frontiers in Pharmacology |d Frontiers Media S.A., 2010 |g 13(2022) |w (DE-627)DOAJ000099732 |x 16639812 |7 nnns |
773 | 1 | 8 | |g volume:13 |g year:2022 |
856 | 4 | 0 | |u https://doi.org/10.3389/fphar.2022.799338 |z kostenfrei |
856 | 4 | 0 | |u https://doaj.org/article/f956ff3340d94fc980933175d84065a8 |z kostenfrei |
856 | 4 | 0 | |u https://www.frontiersin.org/articles/10.3389/fphar.2022.799338/full |z kostenfrei |
856 | 4 | 2 | |u https://doaj.org/toc/1663-9812 |y Journal toc |z kostenfrei |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_DOAJ | ||
951 | |a AR | ||
952 | |d 13 |j 2022 |