TNF-α Increase in a Cohort of Depressive Patients
Background. The model of neuroinflammation has been proposed as a possible explanation of depression. Investigations of serum levels of tumor necrosis factor-α (TNF-α) in depressed patients have previously shown contradictory results of increased and decreased levels of TNF-α during the treatment of depression. Methods. We compared the serum levels of TNF-α in two cohorts of patients suffering from depression (ICD-10 criteria): one cohort from a psychotherapeutic unit (n=18), where patients were treated with Cognitive Behavioral Analysis System of Psychotherapy (CBASP), and the other cohort from a psychiatric day care unit (n=16). Both cohorts were investigated at the beginning and at the end of treatment. The intensity of depression was measured by means of the Beck Depression Inventory, 2nd edition (BDI-II) at both time points. Results. We observed a statistically significant increase of TNF-α in the psychotherapeutic unit at time point 2 compared to time point 1 (T=−14.71, p<0.001), but not in the psychiatric day care unit. In both cohorts, BDI-II scores at time point 2 were significantly decreased compared to time point 1 (psychiatric day care unit: T=3.32, p=0.005; psychotherapeutic unit: T=6.22, p<0.001). There was a significant correlation in the psychotherapeutic unit at time point 2 (r=−0.682, p=0.02). Conclusion. As TNF-α was increased at time point 2 in the psychotherapeutic unit but not in patients of the psychiatric day care unit, we propose the different durations of pretreatments in both cohorts and the associated processes of neuroinflammation as a possible explanation for our results. The lack of information about the time course of TNF-α in depression could in general explain the huge variety of TNF-α levels in different cohorts of depressed patients reported in the literature..
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2021 |
|---|---|
| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2021 |
|---|---|
| Enthalten in: |
Disease Markers - (2021) |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Adrian Groh [VerfasserIn] |
|---|
| Links: |
doi.org [kostenfrei] |
|---|
| Themen: |
|---|
| doi: |
10.1155/2021/8897421 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
DOAJ048578258 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | DOAJ048578258 | ||
| 003 | DE-627 | ||
| 005 | 20230227155108.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 230227s2021 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1155/2021/8897421 |2 doi | |
| 035 | |a (DE-627)DOAJ048578258 | ||
| 035 | |a (DE-599)DOAJe643b67934eb4a06b860e52f472a4190 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 050 | 0 | |a R5-920 | |
| 100 | 0 | |a Adrian Groh |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a TNF-α Increase in a Cohort of Depressive Patients |
| 264 | 1 | |c 2021 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 520 | |a Background. The model of neuroinflammation has been proposed as a possible explanation of depression. Investigations of serum levels of tumor necrosis factor-α (TNF-α) in depressed patients have previously shown contradictory results of increased and decreased levels of TNF-α during the treatment of depression. Methods. We compared the serum levels of TNF-α in two cohorts of patients suffering from depression (ICD-10 criteria): one cohort from a psychotherapeutic unit (n=18), where patients were treated with Cognitive Behavioral Analysis System of Psychotherapy (CBASP), and the other cohort from a psychiatric day care unit (n=16). Both cohorts were investigated at the beginning and at the end of treatment. The intensity of depression was measured by means of the Beck Depression Inventory, 2nd edition (BDI-II) at both time points. Results. We observed a statistically significant increase of TNF-α in the psychotherapeutic unit at time point 2 compared to time point 1 (T=−14.71, p<0.001), but not in the psychiatric day care unit. In both cohorts, BDI-II scores at time point 2 were significantly decreased compared to time point 1 (psychiatric day care unit: T=3.32, p=0.005; psychotherapeutic unit: T=6.22, p<0.001). There was a significant correlation in the psychotherapeutic unit at time point 2 (r=−0.682, p=0.02). Conclusion. As TNF-α was increased at time point 2 in the psychotherapeutic unit but not in patients of the psychiatric day care unit, we propose the different durations of pretreatments in both cohorts and the associated processes of neuroinflammation as a possible explanation for our results. The lack of information about the time course of TNF-α in depression could in general explain the huge variety of TNF-α levels in different cohorts of depressed patients reported in the literature. | ||
| 653 | 0 | |a Medicine (General) | |
| 700 | 0 | |a Kirsten Jahn |e verfasserin |4 aut | |
| 700 | 0 | |a Marc Walter |e verfasserin |4 aut | |
| 700 | 0 | |a Johannes Heck |e verfasserin |4 aut | |
| 700 | 0 | |a Ralf Lichtinghagen |e verfasserin |4 aut | |
| 700 | 0 | |a Eva Janke |e verfasserin |4 aut | |
| 700 | 0 | |a Schulze Westhoff M. L |e verfasserin |4 aut | |
| 700 | 0 | |a Maximillian Deest |e verfasserin |4 aut | |
| 700 | 0 | |a Helge Frieling |e verfasserin |4 aut | |
| 700 | 0 | |a Stefan Bleich |e verfasserin |4 aut | |
| 700 | 0 | |a Kai G. Kahl |e verfasserin |4 aut | |
| 700 | 0 | |a Annemarie Heberlein |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i In |t Disease Markers |d Hindawi Limited, 2013 |g (2021) |w (DE-627)DOAJ000114669 |x 18758630 |7 nnns |
| 773 | 1 | 8 | |g year:2021 |
| 856 | 4 | 0 | |u https://doi.org/10.1155/2021/8897421 |z kostenfrei |
| 856 | 4 | 0 | |u https://doaj.org/article/e643b67934eb4a06b860e52f472a4190 |z kostenfrei |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1155/2021/8897421 |z kostenfrei |
| 856 | 4 | 2 | |u https://doaj.org/toc/0278-0240 |y Journal toc |z kostenfrei |
| 856 | 4 | 2 | |u https://doaj.org/toc/1875-8630 |y Journal toc |z kostenfrei |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_DOAJ | ||
| 951 | |a AR | ||
| 952 | |j 2021 | ||