Efficacy and Tolerability of Lopinavir/Ritonavir- and Efavirenz-Based Initial Antiretroviral Therapy in HIV-1-Infected Patients in a Tertiary Care Hospital in Beijing, China
Background: Lopinavir/ritonavir (LPV/r) is a major antiretroviral treatment in China, but little is known about the performance of first-line LPV/r-based regimen in treatment-naïve patients with human immunodeficiency virus type 1 (HIV-1) infection. This study aims to assess the efficacy and adverse effect events of LPV/r plus lamivudine and tenofovir or zidovudine as an initial antiretroviral treatment in HIV-1-infected individuals for whom cannot take efavirenz (EFV) or is allergic to EFV.Methods: We performed a retrospective study of patients registering with the China’s National Free Antiretroviral Treatment Program from July 2012 to January 2017, followed at a tertiary care hospital in Beijing, China. The primary outcome was the proportion of subjects with HIV-1 RNA ≤40 copies/ml at 6 and 24 months of treatment. We assessed the immunological response and adverse events.Results: In total, 4,862 patients were enrolled in the study and 237 were eligible for analysis in each study arm. During the first six months, virological suppression was better with the LPV/r-based regimen than with the EFV-based regimen (93.80 vs 87.80% for P < 0.05). Viral suppression rates continued to increase until 12 months, remain steady thereafter until 24 months, for both groups. The multilevel analysis revealed that patients in the LPV/r group were more likely to display improvements in CD4 T-cell count over time than those in the EFV group (P < 0.001). Grade 3 or 4 laboratory adverse events were observed in 14 patients (5.91%) from the LPV/r group and three patients (1.20%) in EFV group.Conclusion: Our findings demonstrate that LPV/r-containing regimens are effective and well-tolerated in Chinese treatment-naïve patients with HIV-1 infection..
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2019 |
---|---|
Erschienen: |
2019 |
Enthalten in: |
Zur Gesamtaufnahme - volume:10 |
---|---|
Enthalten in: |
Frontiers in Pharmacology - 10(2019) |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Bin Su [VerfasserIn] |
---|
Links: |
doi.org [kostenfrei] |
---|
Themen: |
Adverse effects |
---|
doi: |
10.3389/fphar.2019.01472 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
DOAJ046868666 |
---|
LEADER | 01000caa a22002652 4500 | ||
---|---|---|---|
001 | DOAJ046868666 | ||
003 | DE-627 | ||
005 | 20230308114550.0 | ||
007 | cr uuu---uuuuu | ||
008 | 230227s2019 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.3389/fphar.2019.01472 |2 doi | |
035 | |a (DE-627)DOAJ046868666 | ||
035 | |a (DE-599)DOAJecb3fb25ba604eb6b37b26b94f6a1f3c | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
050 | 0 | |a RM1-950 | |
100 | 0 | |a Bin Su |e verfasserin |4 aut | |
245 | 1 | 0 | |a Efficacy and Tolerability of Lopinavir/Ritonavir- and Efavirenz-Based Initial Antiretroviral Therapy in HIV-1-Infected Patients in a Tertiary Care Hospital in Beijing, China |
264 | 1 | |c 2019 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a Computermedien |b c |2 rdamedia | ||
338 | |a Online-Ressource |b cr |2 rdacarrier | ||
520 | |a Background: Lopinavir/ritonavir (LPV/r) is a major antiretroviral treatment in China, but little is known about the performance of first-line LPV/r-based regimen in treatment-naïve patients with human immunodeficiency virus type 1 (HIV-1) infection. This study aims to assess the efficacy and adverse effect events of LPV/r plus lamivudine and tenofovir or zidovudine as an initial antiretroviral treatment in HIV-1-infected individuals for whom cannot take efavirenz (EFV) or is allergic to EFV.Methods: We performed a retrospective study of patients registering with the China’s National Free Antiretroviral Treatment Program from July 2012 to January 2017, followed at a tertiary care hospital in Beijing, China. The primary outcome was the proportion of subjects with HIV-1 RNA ≤40 copies/ml at 6 and 24 months of treatment. We assessed the immunological response and adverse events.Results: In total, 4,862 patients were enrolled in the study and 237 were eligible for analysis in each study arm. During the first six months, virological suppression was better with the LPV/r-based regimen than with the EFV-based regimen (93.80 vs 87.80% for P < 0.05). Viral suppression rates continued to increase until 12 months, remain steady thereafter until 24 months, for both groups. The multilevel analysis revealed that patients in the LPV/r group were more likely to display improvements in CD4 T-cell count over time than those in the EFV group (P < 0.001). Grade 3 or 4 laboratory adverse events were observed in 14 patients (5.91%) from the LPV/r group and three patients (1.20%) in EFV group.Conclusion: Our findings demonstrate that LPV/r-containing regimens are effective and well-tolerated in Chinese treatment-naïve patients with HIV-1 infection. | ||
650 | 4 | |a human immunodeficiency virus | |
650 | 4 | |a first-line therapy | |
650 | 4 | |a antiretroviral therapy | |
650 | 4 | |a lopinavir/ritonavir | |
650 | 4 | |a efavirenz | |
650 | 4 | |a adverse effects | |
653 | 0 | |a Therapeutics. Pharmacology | |
700 | 0 | |a Bin Su |e verfasserin |4 aut | |
700 | 0 | |a Yin Wang |e verfasserin |4 aut | |
700 | 0 | |a Ruifeng Zhou |e verfasserin |4 aut | |
700 | 0 | |a Taiyi Jiang |e verfasserin |4 aut | |
700 | 0 | |a Taiyi Jiang |e verfasserin |4 aut | |
700 | 0 | |a Hongwei Zhang |e verfasserin |4 aut | |
700 | 0 | |a Zaicun Li |e verfasserin |4 aut | |
700 | 0 | |a An Liu |e verfasserin |4 aut | |
700 | 0 | |a Ying Shao |e verfasserin |4 aut | |
700 | 0 | |a Wei Hua |e verfasserin |4 aut | |
700 | 0 | |a Tong Zhang |e verfasserin |4 aut | |
700 | 0 | |a Tong Zhang |e verfasserin |4 aut | |
700 | 0 | |a Hao Wu |e verfasserin |4 aut | |
700 | 0 | |a Hao Wu |e verfasserin |4 aut | |
700 | 0 | |a Shenghua He |e verfasserin |4 aut | |
700 | 0 | |a Lili Dai |e verfasserin |4 aut | |
700 | 0 | |a Lijun Sun |e verfasserin |4 aut | |
773 | 0 | 8 | |i In |t Frontiers in Pharmacology |d Frontiers Media S.A., 2010 |g 10(2019) |w (DE-627)DOAJ000099732 |x 16639812 |7 nnns |
773 | 1 | 8 | |g volume:10 |g year:2019 |
856 | 4 | 0 | |u https://doi.org/10.3389/fphar.2019.01472 |z kostenfrei |
856 | 4 | 0 | |u https://doaj.org/article/ecb3fb25ba604eb6b37b26b94f6a1f3c |z kostenfrei |
856 | 4 | 0 | |u https://www.frontiersin.org/article/10.3389/fphar.2019.01472/full |z kostenfrei |
856 | 4 | 2 | |u https://doaj.org/toc/1663-9812 |y Journal toc |z kostenfrei |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_DOAJ | ||
951 | |a AR | ||
952 | |d 10 |j 2019 |