Assessment of acetylsalicylic acid and clopidogrel resistance results of the patients with significant stenosis on carotid color Doppler ultrasonography

INTRODUCTION: Acetylsalicylic acid resistance and clopidogrel resistance occur when platelet reactivity is higher than the reference range despite receiving antiaggregant therapy. The continuation of thrombotic events despite the use of antithrombotic drugs has led to the concept of antithrombotic resistance. This study aimed to determine the frequency of acetylsalicylic acid-clopidogrel resistance and risk factors associated with resistance in the patients with significant stenosis or occlusion on carotid color Doppler ultrasonography. METHODS: The files of the patients who were hospitalized in our hospital's neurology clinic between 2019-2021 due to the diagnosis of ischemic stroke and transischemic attack were scanned. A total of 60 patients with significant (≥50%) stenosis on carotid color Doppler ultrasonography. and who had acetylsalicylic acid-clopidogrel resistance test were included in the study. Age, gender, obesity, diabete, hypertension, stenosis level, drug use period, HbA1c, creatinine, low-density lipoprotein, haemoglobin value, platelet count, smoking and alcohol, and their relationships with resistance were examined. RESULTS: 28,3% of 60 patients were included in the study were female and 71,7% of them were male. The mean age was found to be 68 Diabetes was determined in 65% of the patients, hypertension was determined in 71,7% of them, elevated low-density lipoprotein was determined in 63,3% and elevated HbA1c was determined in 75%. Acetylsalicylic acid resistance was found in 11 patients (18,3%), and clopidogrel resistance was identified in 12 patients (20%). Acetylsalicylic acid resistance was significantly higher in the patients with older age (≥67) and with low haemoglobin value (≤12,4) (p=0,042 and p=0,014, respectively). Clopidogrel resistance was significantly higher in females (p=0,027). DISCUSSION AND CONCLUSION: Firstly, the main goal should be reducing the risk of stroke with appropriate preventive treatment for risk factors. Patients over the age of 67 and female patients need to be more careful about resistance. We would like to emphasize that low haemoglobin levels should be treated..

Medienart:	E-Artikel

Erscheinungsjahr:	2022
Erschienen:	2022

Enthalten in:	Zur Gesamtaufnahme - volume:28
Enthalten in:	Türk Beyin Damar Hastalıkları Dergisi - 28(2022), 1, Seite 46-53

Sprache:	Englisch ; Türkisch

Beteiligte Personen:	Fatma Yılmaz Can [VerfasserIn] Beyza Nur Çetin [VerfasserIn]

Links:	doi.org [kostenfrei] doaj.org [kostenfrei] jag.journalagent.com [kostenfrei] Journal toc [kostenfrei]

Themen:	Acetylsalicylic acid resistance Carotid artery disease Clopidogrel resistance Medicine R

doi:	10.5505/tbdhd.2022.57805

funding:
Förderinstitution / Projekttitel:

PPN (Katalog-ID):	DOAJ044335156