Prediction of Methotrexate toxicity in Algerian Rheumatoid Arthritis Patients: Implication of GGH rs11545078 polymorphism
Objectives - The aim of this study is to determine the impact of the gamma glutamyl hydrolase (GGH) c.452C<T (dbSNP Id: rs 11545078) polymorphism on the Methotrexate (MTX) adverse drug reactions (ADRs) and on MTX gastro intestinal toxicity (GIT) in rheumatoid arthritis (RA) patients. Materials and methods - Sixty-one patients with RA are enrolled in this study. Genotyping was performed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique. Data were analyzed by χ2. Results - Our findings suggest that the frequencies distributions of alleles/genotypes of this polymorphism were similar in both groups with and without ADRs. However, there is a significant distribution of GGH 452TT (p=0.03) and GGH 452CT+452TT (p=0.02) genotypes between the groups with and without GIT. The same correlation was found for GGH 452T allele (p=0.008). Conclusion - We have shown for the first time in the West Algerian population that the GGH c.452C<T polymorphism influences the MTX gastro-intestinal toxicity..
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:1 |
|---|---|
| Enthalten in: |
Journal de la Faculté de Médecine d'Oran - 1(2022), 3 |
| Sprache: |
Englisch ; Französisch |
|---|
| Beteiligte Personen: |
Wefa Boughrara [VerfasserIn] |
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| Links: |
doaj.org [kostenfrei] |
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| Themen: |
Algeria |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
DOAJ043408036 |
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| 520 | |a Objectives - The aim of this study is to determine the impact of the gamma glutamyl hydrolase (GGH) c.452C<T (dbSNP Id: rs 11545078) polymorphism on the Methotrexate (MTX) adverse drug reactions (ADRs) and on MTX gastro intestinal toxicity (GIT) in rheumatoid arthritis (RA) patients. Materials and methods - Sixty-one patients with RA are enrolled in this study. Genotyping was performed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique. Data were analyzed by χ2. Results - Our findings suggest that the frequencies distributions of alleles/genotypes of this polymorphism were similar in both groups with and without ADRs. However, there is a significant distribution of GGH 452TT (p=0.03) and GGH 452CT+452TT (p=0.02) genotypes between the groups with and without GIT. The same correlation was found for GGH 452T allele (p=0.008). Conclusion - We have shown for the first time in the West Algerian population that the GGH c.452C<T polymorphism influences the MTX gastro-intestinal toxicity. | ||
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