Vitamin D and disease severity in coronavirus disease 19 (COVID-19)
The role of 25-OH-vitamin D in the assessment of coronavirus disease 19 (COVID-19) has not been investigated. We sought to investigate the prevalence of 25-OH-vitamin D deficiency among COVID-19 patients, and to determine the associations between 25-OH-vitamin D status and the severity of the disease. We have conducted a retrospective observational study of COVID-19 patients admitted to the University of Verona Hospital Trust. Demographic, clinical and biochemical parameters were collected at hospital admission, and serum 25-OH-vitamin D levels were measured. The following outcomes were assessed: arterial partial oxygen pressure (PaO2); C-reactive protein (CRP); length of hospitalization; requirement of oxygen therapy; non-invasive ventilation (NIV); mechanical ventilation; and death. Among 61 patients enrolled, 72.1% was 25-OH-vitamin D deficient (<20 ng/mL) and 57.4% had 25-OHvitamin D <15 ng/mL. Patients with arterial PaO2 <60 mmHg had significantly lower mean 25-OH-vitamin D levels compared to patients with PaO2 ≥60 mmHg (13.3 ng/mL vs 20.4 ng/mL respectively, p=0.03). Vitamin D deficiency was associated with 3-fold higher risk of having arterial pO2 <60 mmHg. 25-OH-vitamin D deficiency was associated with increased CRP and dyspnea. 25-OH-vitamin D deficiency was associated with more severe systemic inflammatory response and respiratory failure in COVID-19 patients..
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2021 |
|---|---|
| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:72 |
|---|---|
| Enthalten in: |
Reumatismo - 72(2021), 4 |
| Sprache: |
Englisch ; Italienisch |
|---|
| Beteiligte Personen: |
G. Adami [VerfasserIn] |
|---|
| Links: |
doi.org [kostenfrei] |
|---|
| Themen: |
|---|
| doi: |
10.4081/reumatismo.2020.1333 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
DOAJ042314801 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | DOAJ042314801 | ||
| 003 | DE-627 | ||
| 005 | 20230308060400.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 230227s2021 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.4081/reumatismo.2020.1333 |2 doi | |
| 035 | |a (DE-627)DOAJ042314801 | ||
| 035 | |a (DE-599)DOAJ9a50c864490741ff8e86367c49d0eeb6 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng |a ita | ||
| 050 | 0 | |a RC31-1245 | |
| 100 | 0 | |a G. Adami |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Vitamin D and disease severity in coronavirus disease 19 (COVID-19) |
| 264 | 1 | |c 2021 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 520 | |a The role of 25-OH-vitamin D in the assessment of coronavirus disease 19 (COVID-19) has not been investigated. We sought to investigate the prevalence of 25-OH-vitamin D deficiency among COVID-19 patients, and to determine the associations between 25-OH-vitamin D status and the severity of the disease. We have conducted a retrospective observational study of COVID-19 patients admitted to the University of Verona Hospital Trust. Demographic, clinical and biochemical parameters were collected at hospital admission, and serum 25-OH-vitamin D levels were measured. The following outcomes were assessed: arterial partial oxygen pressure (PaO2); C-reactive protein (CRP); length of hospitalization; requirement of oxygen therapy; non-invasive ventilation (NIV); mechanical ventilation; and death. Among 61 patients enrolled, 72.1% was 25-OH-vitamin D deficient (<20 ng/mL) and 57.4% had 25-OHvitamin D <15 ng/mL. Patients with arterial PaO2 <60 mmHg had significantly lower mean 25-OH-vitamin D levels compared to patients with PaO2 ≥60 mmHg (13.3 ng/mL vs 20.4 ng/mL respectively, p=0.03). Vitamin D deficiency was associated with 3-fold higher risk of having arterial pO2 <60 mmHg. 25-OH-vitamin D deficiency was associated with increased CRP and dyspnea. 25-OH-vitamin D deficiency was associated with more severe systemic inflammatory response and respiratory failure in COVID-19 patients. | ||
| 650 | 4 | |a COVID-19 | |
| 650 | 4 | |a vitamin D | |
| 650 | 4 | |a SARS-CoV-2. | |
| 653 | 0 | |a Medicine | |
| 653 | 0 | |a R | |
| 653 | 0 | |a Internal medicine | |
| 700 | 0 | |a A. Giollo |e verfasserin |4 aut | |
| 700 | 0 | |a A. Fassio |e verfasserin |4 aut | |
| 700 | 0 | |a C. Benini |e verfasserin |4 aut | |
| 700 | 0 | |a E. Bertoldo |e verfasserin |4 aut | |
| 700 | 0 | |a F. Bertoldo |e verfasserin |4 aut | |
| 700 | 0 | |a G. Orsolini |e verfasserin |4 aut | |
| 700 | 0 | |a L. Idolazzi |e verfasserin |4 aut | |
| 700 | 0 | |a O. Viapiana |e verfasserin |4 aut | |
| 700 | 0 | |a S. Giannini |e verfasserin |4 aut | |
| 700 | 0 | |a G. Passeri |e verfasserin |4 aut | |
| 700 | 0 | |a E. Tacconelli |e verfasserin |4 aut | |
| 700 | 0 | |a C. Micheletto |e verfasserin |4 aut | |
| 700 | 0 | |a D. Gatti |e verfasserin |4 aut | |
| 700 | 0 | |a M. Rossini |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i In |t Reumatismo |d PAGEPress Publications, 2012 |g 72(2021), 4 |w (DE-627)DOAJ000058424 |x 22402683 |7 nnns |
| 773 | 1 | 8 | |g volume:72 |g year:2021 |g number:4 |
| 856 | 4 | 0 | |u https://doi.org/10.4081/reumatismo.2020.1333 |z kostenfrei |
| 856 | 4 | 0 | |u https://doaj.org/article/9a50c864490741ff8e86367c49d0eeb6 |z kostenfrei |
| 856 | 4 | 0 | |u https://reumatismo.org/index.php/reuma/article/view/1333 |z kostenfrei |
| 856 | 4 | 2 | |u https://doaj.org/toc/0048-7449 |y Journal toc |z kostenfrei |
| 856 | 4 | 2 | |u https://doaj.org/toc/2240-2683 |y Journal toc |z kostenfrei |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_DOAJ | ||
| 951 | |a AR | ||
| 952 | |d 72 |j 2021 |e 4 | ||