Strategies to Mitigate Establishment under the <i<Wolbachia</i< Incompatible Insect Technique
The Incompatible Insect Technique (IIT) strategy involves the release of male mosquitoes infected with the bacterium <i<Wolbachia</i<. Regular releases of male <i<Wolbachia</i<-infected mosquitoes can lead to the suppression of mosquito populations, thereby reducing the risk of transmission of vector-borne diseases such as dengue. However, due to imperfect sex-sorting under IIT, fertile <i<Wolbachia</i<-infected female mosquitoes may potentially be unintentionally released into the environment, which may result in replacement and failure to suppress the mosquito populations. As such, mitigating <i<Wolbachia</i< establishment requires a combination of IIT with other strategies. We introduced a simple compartmental model to simulate ex-ante mosquito population dynamics subjected to a <i<Wolbachia</i<-IIT programme. In silico, we explored the risk of replacement, and strategies that could mitigate the establishment of the released <i<Wolbachia</i< strain in the mosquito population. Our results suggest that mitigation may be achieved through the application of a sterile insect technique. Our simulations indicate that these interventions do not override the intended wild type suppression of the IIT approach. These findings will inform policy makers of possible ways to mitigate the potential establishment of <i<Wolbachia</i< using the IIT population control strategy..
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:14 |
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| Enthalten in: |
Viruses - 14(2022), 6, p 1132 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Stacy Soh [VerfasserIn] |
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| Links: |
doi.org [kostenfrei] |
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| Themen: |
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| doi: |
10.3390/v14061132 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
DOAJ042238226 |
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| 520 | |a The Incompatible Insect Technique (IIT) strategy involves the release of male mosquitoes infected with the bacterium <i<Wolbachia</i<. Regular releases of male <i<Wolbachia</i<-infected mosquitoes can lead to the suppression of mosquito populations, thereby reducing the risk of transmission of vector-borne diseases such as dengue. However, due to imperfect sex-sorting under IIT, fertile <i<Wolbachia</i<-infected female mosquitoes may potentially be unintentionally released into the environment, which may result in replacement and failure to suppress the mosquito populations. As such, mitigating <i<Wolbachia</i< establishment requires a combination of IIT with other strategies. We introduced a simple compartmental model to simulate ex-ante mosquito population dynamics subjected to a <i<Wolbachia</i<-IIT programme. In silico, we explored the risk of replacement, and strategies that could mitigate the establishment of the released <i<Wolbachia</i< strain in the mosquito population. Our results suggest that mitigation may be achieved through the application of a sterile insect technique. Our simulations indicate that these interventions do not override the intended wild type suppression of the IIT approach. These findings will inform policy makers of possible ways to mitigate the potential establishment of <i<Wolbachia</i< using the IIT population control strategy. | ||
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| 700 | 0 | |a Annabel Seah |e verfasserin |4 aut | |
| 700 | 0 | |a Borame Sue Dickens |e verfasserin |4 aut | |
| 700 | 0 | |a Ken Wei Tan |e verfasserin |4 aut | |
| 700 | 0 | |a Joel Ruihan Koo |e verfasserin |4 aut | |
| 700 | 0 | |a Alex R. Cook |e verfasserin |4 aut | |
| 700 | 0 | |a Shuzhen Sim |e verfasserin |4 aut | |
| 700 | 0 | |a Cheong Huat Tan |e verfasserin |4 aut | |
| 700 | 0 | |a Lee Ching Ng |e verfasserin |4 aut | |
| 700 | 0 | |a Jue Tao Lim |e verfasserin |4 aut | |
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