Coinfection with Mycoplasma Pneumoniae and Chlamydia Pneumoniae in ruptured plaques associated with acute myocardial infarction
OBJECTIVE: To study atheromas, Mycoplasma pneumoniae (M. pneumoniae), and Chlamydia pneumoniae (C. pneumoniae). METHODS: C. pneumoniae was studied with immunohistochemistry and M. pneumoniae with in situ hybridization (ISH), in segments of coronary arteries (SCA) as follows: group A - thrombosed ruptured plaques (TRP) of 23 patients who died due to acute myocardial infarction (AMI); group B - 23 nonruptured plaques (NRP) of group A patients; group C - NRP of 11 coronary patients who did not die due to AMI; and group D - 11 SCA from patients with dilated cardiomyopathy or Chagas' disease without atherosclerosis. RESULTS: The mean number of C. pneumoniae+ cells/400x in groups A, B, C, and D was, respectively, 3.3±3.6; 1.0±1.3; 1.2±2.4; and 0.4±0.3; and the percentage of M. pneumoniae area was, respectively, 3.9±3.5; 1.5± 1.6; 0.9±0.9; and 0.4±0.2. More M. pneumoniae and C. pneumoniae were found in of group A than in group B (P<0.01). Good correlation was seen between the area of the vessel and the M. pneumoniae area in the plaque (r = 0.46; P=0.001) and between C. pneumoniae+ cells and CD4+ T lymphocytes (r = 0.42; P<0.01). The number of C. pneumoniae+ cells correlated with CD20+ B cells (r=0.48; P<0.01). CONCLUSION: M. pneumoniae and C. pneumoniae are more frequently found in TRP correlate with the intensity of the inflammation and diameter of the vessel (positive remodeling)..
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2003 |
|---|---|
| Erschienen: |
2003 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:81 |
|---|---|
| Enthalten in: |
Arquivos Brasileiros de Cardiologia - 81(2003), 1, Seite 12-22 |
| Sprache: |
Englisch ; Portugiesisch |
|---|
| Beteiligte Personen: |
Maria de Lourdes Higuchi [VerfasserIn] |
|---|
| Links: |
doi.org [kostenfrei] |
|---|
| Themen: |
Acute myocardial infarction |
|---|
| doi: |
10.1590/S0066-782X2003000900001 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
DOAJ039608352 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | DOAJ039608352 | ||
| 003 | DE-627 | ||
| 005 | 20230308031920.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 230227s2003 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1590/S0066-782X2003000900001 |2 doi | |
| 035 | |a (DE-627)DOAJ039608352 | ||
| 035 | |a (DE-599)DOAJed1ff23dceef45e6b0260f4e784f6385 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng |a por | ||
| 050 | 0 | |a RC666-701 | |
| 100 | 0 | |a Maria de Lourdes Higuchi |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Coinfection with Mycoplasma Pneumoniae and Chlamydia Pneumoniae in ruptured plaques associated with acute myocardial infarction |
| 264 | 1 | |c 2003 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 520 | |a OBJECTIVE: To study atheromas, Mycoplasma pneumoniae (M. pneumoniae), and Chlamydia pneumoniae (C. pneumoniae). METHODS: C. pneumoniae was studied with immunohistochemistry and M. pneumoniae with in situ hybridization (ISH), in segments of coronary arteries (SCA) as follows: group A - thrombosed ruptured plaques (TRP) of 23 patients who died due to acute myocardial infarction (AMI); group B - 23 nonruptured plaques (NRP) of group A patients; group C - NRP of 11 coronary patients who did not die due to AMI; and group D - 11 SCA from patients with dilated cardiomyopathy or Chagas' disease without atherosclerosis. RESULTS: The mean number of C. pneumoniae+ cells/400x in groups A, B, C, and D was, respectively, 3.3±3.6; 1.0±1.3; 1.2±2.4; and 0.4±0.3; and the percentage of M. pneumoniae area was, respectively, 3.9±3.5; 1.5± 1.6; 0.9±0.9; and 0.4±0.2. More M. pneumoniae and C. pneumoniae were found in of group A than in group B (P<0.01). Good correlation was seen between the area of the vessel and the M. pneumoniae area in the plaque (r = 0.46; P=0.001) and between C. pneumoniae+ cells and CD4+ T lymphocytes (r = 0.42; P<0.01). The number of C. pneumoniae+ cells correlated with CD20+ B cells (r=0.48; P<0.01). CONCLUSION: M. pneumoniae and C. pneumoniae are more frequently found in TRP correlate with the intensity of the inflammation and diameter of the vessel (positive remodeling). | ||
| 650 | 4 | |a Mycoplasma pneumoniae | |
| 650 | 4 | |a Chlamydia pneumoniae | |
| 650 | 4 | |a acute myocardial infarction | |
| 653 | 0 | |a Diseases of the circulatory (Cardiovascular) system | |
| 700 | 0 | |a Marcia Martins Reis |e verfasserin |4 aut | |
| 700 | 0 | |a Nádia Vieira Sambiase |e verfasserin |4 aut | |
| 700 | 0 | |a Suely Aparecida Pinheiro Palomino |e verfasserin |4 aut | |
| 700 | 0 | |a Jussara Bianchi Castelli |e verfasserin |4 aut | |
| 700 | 0 | |a Paulo Sampaio Gutierrez |e verfasserin |4 aut | |
| 700 | 0 | |a Vera Demarchi Aiello |e verfasserin |4 aut | |
| 700 | 0 | |a José Antonio Franchini Ramires |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i In |t Arquivos Brasileiros de Cardiologia |d Sociedade Brasileira de Cardiologia (SBC), 2004 |g 81(2003), 1, Seite 12-22 |w (DE-627)DOAJ000116564 |x 16784170 |7 nnns |
| 773 | 1 | 8 | |g volume:81 |g year:2003 |g number:1 |g pages:12-22 |
| 856 | 4 | 0 | |u https://doi.org/10.1590/S0066-782X2003000900001 |z kostenfrei |
| 856 | 4 | 0 | |u https://doaj.org/article/ed1ff23dceef45e6b0260f4e784f6385 |z kostenfrei |
| 856 | 4 | 0 | |u http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2003000900001 |z kostenfrei |
| 856 | 4 | 2 | |u https://doaj.org/toc/0066-782X |y Journal toc |z kostenfrei |
| 856 | 4 | 2 | |u https://doaj.org/toc/1678-4170 |y Journal toc |z kostenfrei |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_DOAJ | ||
| 951 | |a AR | ||
| 952 | |d 81 |j 2003 |e 1 |h 12-22 | ||