Polyacetylenes from the Roots of <i<Swietenia macrophylla</i< King
A phytochemical investigation of the roots of <i<Swietenia macrophylla</i< led to the isolation of seven polyacetylenes, including five new compounds (<b<1</b<–<b<5</b<) and two known ones (<b<6</b<–<b<7</b<). Their structures were elucidated by extensive spectroscopic analysis and detailed comparison with reported data. All the isolates were tested for their cytotoxicity against the human hepatocellular carcinoma cell line BEL-7402, human myeloid leukemia cell line K562, and human gastric carcinoma cell line SGC-7901. Compounds <b<1</b< and <b<6</b< showed moderate cytotoxicity against the above three human cancer cell lines with IC<sub<50</sub< values ranging from 14.3 to 45.4 μM. Compound <b<4</b< displayed cytotoxicity against the K562 and SGC-7901 cancer cell lines with IC<sub<50</sub< values of 26.2 ± 0.4 and 21.9 ± 0.3 μM, respectively..
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2019 |
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| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:24 |
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| Enthalten in: |
Molecules - 24(2019), 7, p 1291 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Cheng-Neng Mi [VerfasserIn] |
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| Links: |
doi.org [kostenfrei] |
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| Themen: |
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| doi: |
10.3390/molecules24071291 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
DOAJ038909820 |
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| 520 | |a A phytochemical investigation of the roots of <i<Swietenia macrophylla</i< led to the isolation of seven polyacetylenes, including five new compounds (<b<1</b<–<b<5</b<) and two known ones (<b<6</b<–<b<7</b<). Their structures were elucidated by extensive spectroscopic analysis and detailed comparison with reported data. All the isolates were tested for their cytotoxicity against the human hepatocellular carcinoma cell line BEL-7402, human myeloid leukemia cell line K562, and human gastric carcinoma cell line SGC-7901. Compounds <b<1</b< and <b<6</b< showed moderate cytotoxicity against the above three human cancer cell lines with IC<sub<50</sub< values ranging from 14.3 to 45.4 μM. Compound <b<4</b< displayed cytotoxicity against the K562 and SGC-7901 cancer cell lines with IC<sub<50</sub< values of 26.2 ± 0.4 and 21.9 ± 0.3 μM, respectively. | ||
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