Effect of a previous history of antiretroviral treatment on the clinical picture of patients with co-infection of SARS-CoV-2 and HIV: A preliminary study
Objectives: We explored the effect of antiretroviral treatment (ART) history on clinical characteristics of patients with SARS-CoV-2 and HIV co-infection. Methods: We retrospectively reviewed 20 patients with laboratory-confirmed co-infection of SARS-CoV-2 and HIV in a designated hospital. Patients were divided into medicine (n = 12) and non-medicine (n = 8) groups according to previous ART history before SARS-CoV-2 infection. Results: The median age was 46.5 years and 15 (75%) were female. Ten patients had initial negative RT-PCR on admission, five of which had normal computed tomography (CT) appearance and four were asymptomatic. Lymphocytes were low in nine patients (45%); CD4 cell count and CD4/CD8 were low in all patients. The predominant CT features in 19 patients were multiple (42%) ground-glass opacities (58%) and consolidations (32%). Erythrocyte sedimentation rate was significantly lower in the medicine than the non-medicine group [median (interquartile range, IQR): 14.0 (10.0–34.0) vs 51.0 (35.8–62.0), P = 0.005]. Nineteen patients (95%) were discharged with a median hospital stay of 30 days (IQR 26–30). Conclusions: Most patients with SARS-CoV-2 and HIV co-infection exhibited mild to moderate symptoms. The milder inflammatory response to SARS-CoV-2 infection might be associated with a previous history of ART in HIV-infected patients..
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
2020 |
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Erschienen: |
2020 |
Enthalten in: |
Zur Gesamtaufnahme - volume:100 |
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Enthalten in: |
International Journal of Infectious Diseases - 100(2020), Seite 141-148 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Jia Liu [VerfasserIn] |
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Links: |
doi.org [kostenfrei] |
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Themen: |
Antiretroviral therapy |
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doi: |
10.1016/j.ijid.2020.08.045 |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
DOAJ037192167 |
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520 | |a Objectives: We explored the effect of antiretroviral treatment (ART) history on clinical characteristics of patients with SARS-CoV-2 and HIV co-infection. Methods: We retrospectively reviewed 20 patients with laboratory-confirmed co-infection of SARS-CoV-2 and HIV in a designated hospital. Patients were divided into medicine (n = 12) and non-medicine (n = 8) groups according to previous ART history before SARS-CoV-2 infection. Results: The median age was 46.5 years and 15 (75%) were female. Ten patients had initial negative RT-PCR on admission, five of which had normal computed tomography (CT) appearance and four were asymptomatic. Lymphocytes were low in nine patients (45%); CD4 cell count and CD4/CD8 were low in all patients. The predominant CT features in 19 patients were multiple (42%) ground-glass opacities (58%) and consolidations (32%). Erythrocyte sedimentation rate was significantly lower in the medicine than the non-medicine group [median (interquartile range, IQR): 14.0 (10.0–34.0) vs 51.0 (35.8–62.0), P = 0.005]. Nineteen patients (95%) were discharged with a median hospital stay of 30 days (IQR 26–30). Conclusions: Most patients with SARS-CoV-2 and HIV co-infection exhibited mild to moderate symptoms. The milder inflammatory response to SARS-CoV-2 infection might be associated with a previous history of ART in HIV-infected patients. | ||
650 | 4 | |a Coronavirus disease 2019 | |
650 | 4 | |a HIV | |
650 | 4 | |a Antiretroviral therapy | |
650 | 4 | |a Characteristics | |
650 | 4 | |a Reverse transcription-polymerase chain reaction | |
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653 | 0 | |a Infectious and parasitic diseases | |
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700 | 0 | |a Yukun Cao |e verfasserin |4 aut | |
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700 | 0 | |a Osamah Alwalid |e verfasserin |4 aut | |
700 | 0 | |a Fan Yang |e verfasserin |4 aut | |
700 | 0 | |a Yanqing Fan |e verfasserin |4 aut | |
700 | 0 | |a Heshui Shi |e verfasserin |4 aut | |
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