Details der Publikation - Hyperglycemia and steroid use increase the risk of rhino-orbito-cerebral mucormycosis regardless of COVID-19 hospitalization: Case-control study, India.

Hyperglycemia and steroid use increase the risk of rhino-orbito-cerebral mucormycosis regardless of COVID-19 hospitalization: Case-control study, India.

<h4<Background</h4<In the ongoing COVID-19 pandemic, an increased incidence of ROCM was noted in India among those infected with COVID. We determined risk factors for rhino-orbito-cerebral mucormycosis (ROCM) post Coronavirus disease 2019 (COVID-19) among those never and ever hospitalized for COVID-19 separately through a multicentric, hospital-based, unmatched case-control study across India.<h4<Methods</h4<We defined cases and controls as those with and without post-COVID ROCM, respectively. We compared their socio-demographics, co-morbidities, steroid use, glycaemic status, and practices. We calculated crude and adjusted odds ratio (AOR) with 95% confidence intervals (CI) through logistic regression. The covariates with a p-value for crude OR of less than 0·20 were considered for the regression model.<h4<Results</h4<Among hospitalised, we recruited 267 cases and 256 controls and 116 cases and 231 controls among never hospitalised. Risk factors (AOR; 95% CI) for post-COVID ROCM among the hospitalised were age 45-59 years (2·1; 1·4 to 3·1), having diabetes mellitus (4·9; 3·4 to 7·1), elevated plasma glucose (6·4; 2·4 to 17·2), steroid use (3·2; 2 to 5·2) and frequent nasal washing (4·8; 1·4 to 17). Among those never hospitalised, age ≥ 60 years (6·6; 3·3 to 13·3), having diabetes mellitus (6·7; 3·8 to 11·6), elevated plasma glucose (13·7; 2·2 to 84), steroid use (9·8; 5·8 to 16·6), and cloth facemask use (2·6; 1·5 to 4·5) were associated with increased risk of post-COVID ROCM.<h4<Conclusions</h4<Hyperglycemia, irrespective of having diabetes mellitus and steroid use, was associated with an increased risk of ROCM independent of COVID-19 hospitalisation. Rational steroid usage and glucose monitoring may reduce the risk of post-COVID..

Medienart:	E-Artikel

Erscheinungsjahr:	2022
Erschienen:	2022

Enthalten in:	Zur Gesamtaufnahme - volume:17
Enthalten in:	PLoS ONE - 17(2022), 8, p e0272042

Sprache:	Englisch

Beteiligte Personen:	Manickam Ponnaiah [VerfasserIn] Sivaraman Ganesan [VerfasserIn] Tarun Bhatnagar [VerfasserIn] Mahalakshmy Thulasingam [VerfasserIn] Marie Gilbert Majella [VerfasserIn] Mathan Karuppiah [VerfasserIn] S A Rizwan [VerfasserIn] Arun Alexander [VerfasserIn] Sonali Sarkar [VerfasserIn] Sitanshu Sekhar Kar [VerfasserIn] Tamilarasu Kadhiravan [VerfasserIn] Aparna Bhatnagar [VerfasserIn] Prasanna Kumar S [VerfasserIn] Vivekanandan M Pillai [VerfasserIn] Pradeep Pankajakshan Nair [VerfasserIn] Rahul Dhodapkar [VerfasserIn] Pampa Ch Toi [VerfasserIn] Rakesh Singh [VerfasserIn] Nirupama Kasthuri [VerfasserIn] Girish C P Kumar [VerfasserIn] Saranya Jaisankar [VerfasserIn] Vaibhav Saini [VerfasserIn] Ankita Kankaria [VerfasserIn] Anuradha Raj [VerfasserIn] Amit Goyal [VerfasserIn] Vidhu Sharma [VerfasserIn] Satyendra Khichar [VerfasserIn] Kapil Soni [VerfasserIn] Mahendra Kumar Garg [VerfasserIn] Kalaiselvi Selvaraj [VerfasserIn] ShriKrishna B H [VerfasserIn] Kranti Bhavana [VerfasserIn] Bhartendu Bharti [VerfasserIn] C M Singh [VerfasserIn] Neha Chaudhary [VerfasserIn] Vijayaravindh R [VerfasserIn] Gopinath K [VerfasserIn] Karthikeyan Palaninathan [VerfasserIn] Simmi Dube [VerfasserIn] Rita Singh Saxena [VerfasserIn] Nikhil Gupta [VerfasserIn] A Rathinavel [VerfasserIn] S Priya [VerfasserIn] Arulsundareshkumar [VerfasserIn] Shama A Bellad [VerfasserIn] Avinash Kavi [VerfasserIn] Anilkumar S Harugop [VerfasserIn] Kailesh Pujary [VerfasserIn] Kirthinath Ballala [VerfasserIn] Sneha Deepak Mallya [VerfasserIn] Hanumanth M Prasad [VerfasserIn] D Ravi [VerfasserIn] N K Balaji [VerfasserIn] Raghuraj Hegde [VerfasserIn] Neha Mishra [VerfasserIn] Shalina Ray [VerfasserIn] S Karthikeyan [VerfasserIn] Sudha Ramalingam [VerfasserIn] A Murali [VerfasserIn] Sudhakar Vaidya [VerfasserIn] Mohit Samadhiya [VerfasserIn] Dhaval Bhojani [VerfasserIn] Somu Lakshmanan [VerfasserIn] Sudagar R B Singh [VerfasserIn] Nataraj Pillai [VerfasserIn] P Deepthi [VerfasserIn] K Banumathi [VerfasserIn] V Sumathi [VerfasserIn] D Ramesh [VerfasserIn] Sonam Poonam Nissar [VerfasserIn] Khushnood M Sheikh [VerfasserIn] Manisha N Patel [VerfasserIn] Vipul Shristava [VerfasserIn] Suresh S Kumar [VerfasserIn] K Shantaraman [VerfasserIn] Rajkamal D Pandian [VerfasserIn] Manoj Murhekar [VerfasserIn] Rakesh Aggarwal [VerfasserIn]

Links:	doi.org [kostenfrei] doaj.org [kostenfrei] doi.org [kostenfrei] Journal toc [kostenfrei]

Themen:	Medicine Q R Science

doi:	10.1371/journal.pone.0272042

funding:
Förderinstitution / Projekttitel:

PPN (Katalog-ID):	DOAJ035020962

Internformat


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520			\|a <h4<Background</h4<In the ongoing COVID-19 pandemic, an increased incidence of ROCM was noted in India among those infected with COVID. We determined risk factors for rhino-orbito-cerebral mucormycosis (ROCM) post Coronavirus disease 2019 (COVID-19) among those never and ever hospitalized for COVID-19 separately through a multicentric, hospital-based, unmatched case-control study across India.<h4<Methods</h4<We defined cases and controls as those with and without post-COVID ROCM, respectively. We compared their socio-demographics, co-morbidities, steroid use, glycaemic status, and practices. We calculated crude and adjusted odds ratio (AOR) with 95% confidence intervals (CI) through logistic regression. The covariates with a p-value for crude OR of less than 0·20 were considered for the regression model.<h4<Results</h4<Among hospitalised, we recruited 267 cases and 256 controls and 116 cases and 231 controls among never hospitalised. Risk factors (AOR; 95% CI) for post-COVID ROCM among the hospitalised were age 45-59 years (2·1; 1·4 to 3·1), having diabetes mellitus (4·9; 3·4 to 7·1), elevated plasma glucose (6·4; 2·4 to 17·2), steroid use (3·2; 2 to 5·2) and frequent nasal washing (4·8; 1·4 to 17). Among those never hospitalised, age ≥ 60 years (6·6; 3·3 to 13·3), having diabetes mellitus (6·7; 3·8 to 11·6), elevated plasma glucose (13·7; 2·2 to 84), steroid use (9·8; 5·8 to 16·6), and cloth facemask use (2·6; 1·5 to 4·5) were associated with increased risk of post-COVID ROCM.<h4<Conclusions</h4<Hyperglycemia, irrespective of having diabetes mellitus and steroid use, was associated with an increased risk of ROCM independent of COVID-19 hospitalisation. Rational steroid usage and glucose monitoring may reduce the risk of post-COVID.
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Hyperglycemia and steroid use increase the risk of rhino-orbito-cerebral mucormycosis regardless of COVID-19 hospitalization: Case-control study, India.

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