Antiviral Resistance in Human Cytomegalovirus Due to UL54 Mutations Without UL97 Mutations
Background: The concurrent detection of human cytomegalovirus (CMV) with UL97 and UL54 mutations is crucial for prescribing adequate antiviral treatment when drug-resistant CMV infection is suspected. We investigated the frequency of resistance-conferring mutations among patients with persistent or recurrent CMV infection and further reviewed the subgroup with UL54 mutations without UL97 mutations. Methods: Patients with persistent or recurrent CMV infection after 4 weeks of treatment with ganciclovir or foscarnet were consecutively enrolled between November 2012 and May 2019. The direct sequencing of UL97 and UL54 was performed to detect resistance mutations in CMV. Results: A total of 101 sequencing datasets were obtained from 65 enrolled patients. CMV UL97 and UL54 mutations were detected in 15.4% (10/65) and 9% (6/65) of patients, respectively. The CMV retrieved from two patients (3%) had mutations in both genes. Four patients with CMV UL54 mutations alone had a history of haploidentical peripheral blood stem cell transplantation, and foscarnet was administered for over 4 weeks to these patients; 21.5% of patients had suspected resistant CMV infection with either UL97 or UL54 mutations. Conclusion: In this study, CMV UL54 mutations but not UL97 mutations were found in patients subjected to prolonged foscarnet administration for CMV disease..
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2022 |
|---|---|
| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:25 |
|---|---|
| Enthalten in: |
Annals of Clinical Microbiology - 25(2022), 2, Seite 45-51 |
| Sprache: |
Englisch ; Koreanisch |
|---|
| Beteiligte Personen: |
Kuenyoul Park [VerfasserIn] |
|---|
| Links: |
doi.org [kostenfrei] |
|---|
| Themen: |
|---|
| doi: |
10.5145/ACM.2022.25.2.2 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
DOAJ034773363 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | DOAJ034773363 | ||
| 003 | DE-627 | ||
| 005 | 20230307192335.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 230227s2022 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.5145/ACM.2022.25.2.2 |2 doi | |
| 035 | |a (DE-627)DOAJ034773363 | ||
| 035 | |a (DE-599)DOAJ09eb461e8c084bc0be4f3b9f8529cebd | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng |a kor | ||
| 050 | 0 | |a QR1-502 | |
| 100 | 0 | |a Kuenyoul Park |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Antiviral Resistance in Human Cytomegalovirus Due to UL54 Mutations Without UL97 Mutations |
| 264 | 1 | |c 2022 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 520 | |a Background: The concurrent detection of human cytomegalovirus (CMV) with UL97 and UL54 mutations is crucial for prescribing adequate antiviral treatment when drug-resistant CMV infection is suspected. We investigated the frequency of resistance-conferring mutations among patients with persistent or recurrent CMV infection and further reviewed the subgroup with UL54 mutations without UL97 mutations. Methods: Patients with persistent or recurrent CMV infection after 4 weeks of treatment with ganciclovir or foscarnet were consecutively enrolled between November 2012 and May 2019. The direct sequencing of UL97 and UL54 was performed to detect resistance mutations in CMV. Results: A total of 101 sequencing datasets were obtained from 65 enrolled patients. CMV UL97 and UL54 mutations were detected in 15.4% (10/65) and 9% (6/65) of patients, respectively. The CMV retrieved from two patients (3%) had mutations in both genes. Four patients with CMV UL54 mutations alone had a history of haploidentical peripheral blood stem cell transplantation, and foscarnet was administered for over 4 weeks to these patients; 21.5% of patients had suspected resistant CMV infection with either UL97 or UL54 mutations. Conclusion: In this study, CMV UL54 mutations but not UL97 mutations were found in patients subjected to prolonged foscarnet administration for CMV disease. | ||
| 650 | 4 | |a antiviral resistance | |
| 650 | 4 | |a cytomegalovirus | |
| 650 | 4 | |a ul54 | |
| 650 | 4 | |a ul97 | |
| 653 | 0 | |a Microbiology | |
| 700 | 0 | |a Kyu-Hwa Hur |e verfasserin |4 aut | |
| 700 | 0 | |a Heungsup Sung |e verfasserin |4 aut | |
| 700 | 0 | |a Sang-Ho Choi |e verfasserin |4 aut | |
| 700 | 0 | |a Mi-Na Kim |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i In |t Annals of Clinical Microbiology |d Korean Society of Clinical Microbiology, 2020 |g 25(2022), 2, Seite 45-51 |w (DE-627)DOAJ078633109 |x 22886850 |7 nnns |
| 773 | 1 | 8 | |g volume:25 |g year:2022 |g number:2 |g pages:45-51 |
| 856 | 4 | 0 | |u https://doi.org/10.5145/ACM.2022.25.2.2 |z kostenfrei |
| 856 | 4 | 0 | |u https://doaj.org/article/09eb461e8c084bc0be4f3b9f8529cebd |z kostenfrei |
| 856 | 4 | 0 | |u https://www.acm.or.kr/acm_22-002/ |z kostenfrei |
| 856 | 4 | 2 | |u https://doaj.org/toc/2288-0585 |y Journal toc |z kostenfrei |
| 856 | 4 | 2 | |u https://doaj.org/toc/2288-6850 |y Journal toc |z kostenfrei |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_DOAJ | ||
| 951 | |a AR | ||
| 952 | |d 25 |j 2022 |e 2 |h 45-51 | ||