COVID19: uncovering interindividual variability for tailoring appropriate therapeutic interventions

The severity of SARS-CoV2 infection, Covid19 disease, should account for the diversity of human individual immunoinflammatory responses. Serum immunological markers during Covid19 illness may lead to individualized therapeutics with better outcomes. Efficient treatment for Covid19 may require: 1) early disease detection, 2) combined drug therapy for 3) targeting the virus replication cycle, and 4) individualized drug treatment for specific immunoinflammatory human profile responses administered in a 5) timely manner. Covid19 is unlikely to be the last emergent human disease with fast pandemic potential. Gathering knowledge on the individual human host profiles of immunoinflammatory responses is an opportunity that could lead us to understand individual differences in response to infection at the individual and population level, paving the way to faster, more efficient strategies to tackle upcoming infectious diseases. This is a position paper based on an integrative non-exhaustive literature revision..

Medienart:

E-Artikel

Erscheinungsjahr:

2022

Erschienen:

2022

Enthalten in:

Zur Gesamtaufnahme - volume:55

Enthalten in:

Medicina - 55(2022), 2

Sprache:

Portugiesisch

Beteiligte Personen:

Maria Goreti Rosa Freitas [VerfasserIn]
Carolina Muruci-Cruz [VerfasserIn]
Luiz Fernando Dale [VerfasserIn]
Luis Eduardo da Cruz [VerfasserIn]
Jorge Kalil [VerfasserIn]

Links:

doaj.org [kostenfrei]
www.revistas.usp.br [kostenfrei]
Journal toc [kostenfrei]
Journal toc [kostenfrei]

Themen:

COVID19
Iceberg model of disease
Immunoinflammatory response
Medicine
R
Severe acute respiratory syndrome
Treatment outcome

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

DOAJ034670874