Factors associated with increased all-cause mortality during the COVID-19 pandemic in Italy
Background: The number of excess deaths during February–March 2020 in Italy, in comparison with previous years, was considerably higher than the recorded COVID19-related deaths. The present study aimed to explore the association of excess mortality with some indices related to the COVID-19 pandemic and its management. Methods: Data on all-cause mortality from 20 February–31 March in the years 2015–2020, and demographic, socioeconomic and healthcare organisation data of each Italian region were obtained from the Italian Institute of Statistics. Non-COVID-19-Imputed Excess Mortality (NCIEM) was calculated as the difference between the excess 2020 mortality and reported COVID-19 mortality. The association of NCIEM with the rate of COVID-19 cases, COVID-19 mortality and other potential moderators was assessed using linear regression models. Results: The nationwide number of excess deaths and COVID-19 deaths was 26,701 and 13,710, respectively, with a difference of 12,991. The NCIEM in different regions showed a direct correlation with COVID-19 mortality (r2 = 0.61, p < 0.001) and total cases (r2 = 0.30, p = 0.012), and an inverse correlation with cases/total tests ratio (r2 = 0.49, p = 0.001). Direct correlations were also found with the proportion of institutionalised elderly, whereas inverse correlations were observed with prevalence of diabetes, cardiovascular mortality and density of general practitioners. Conclusions: The impact of the COVID-19 pandemic on all-cause mortality was considerably greater than that indicated by official counts of victims. Limited testing capacity and causes of death other than COVID-19 could have contributed to the increase in overall mortality rates..
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2020 |
---|---|
Erschienen: |
2020 |
Enthalten in: |
Zur Gesamtaufnahme - volume:98 |
---|---|
Enthalten in: |
International Journal of Infectious Diseases - 98(2020), Seite 121-124 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Edoardo Mannucci [VerfasserIn] |
---|
Links: |
doi.org [kostenfrei] |
---|
Themen: |
---|
doi: |
10.1016/j.ijid.2020.06.077 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
DOAJ034566481 |
---|
LEADER | 01000caa a22002652 4500 | ||
---|---|---|---|
001 | DOAJ034566481 | ||
003 | DE-627 | ||
005 | 20230307191228.0 | ||
007 | cr uuu---uuuuu | ||
008 | 230227s2020 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1016/j.ijid.2020.06.077 |2 doi | |
035 | |a (DE-627)DOAJ034566481 | ||
035 | |a (DE-599)DOAJ0f105fc96bbb419e92a842d280f75a99 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
050 | 0 | |a RC109-216 | |
100 | 0 | |a Edoardo Mannucci |e verfasserin |4 aut | |
245 | 1 | 0 | |a Factors associated with increased all-cause mortality during the COVID-19 pandemic in Italy |
264 | 1 | |c 2020 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a Computermedien |b c |2 rdamedia | ||
338 | |a Online-Ressource |b cr |2 rdacarrier | ||
520 | |a Background: The number of excess deaths during February–March 2020 in Italy, in comparison with previous years, was considerably higher than the recorded COVID19-related deaths. The present study aimed to explore the association of excess mortality with some indices related to the COVID-19 pandemic and its management. Methods: Data on all-cause mortality from 20 February–31 March in the years 2015–2020, and demographic, socioeconomic and healthcare organisation data of each Italian region were obtained from the Italian Institute of Statistics. Non-COVID-19-Imputed Excess Mortality (NCIEM) was calculated as the difference between the excess 2020 mortality and reported COVID-19 mortality. The association of NCIEM with the rate of COVID-19 cases, COVID-19 mortality and other potential moderators was assessed using linear regression models. Results: The nationwide number of excess deaths and COVID-19 deaths was 26,701 and 13,710, respectively, with a difference of 12,991. The NCIEM in different regions showed a direct correlation with COVID-19 mortality (r2 = 0.61, p < 0.001) and total cases (r2 = 0.30, p = 0.012), and an inverse correlation with cases/total tests ratio (r2 = 0.49, p = 0.001). Direct correlations were also found with the proportion of institutionalised elderly, whereas inverse correlations were observed with prevalence of diabetes, cardiovascular mortality and density of general practitioners. Conclusions: The impact of the COVID-19 pandemic on all-cause mortality was considerably greater than that indicated by official counts of victims. Limited testing capacity and causes of death other than COVID-19 could have contributed to the increase in overall mortality rates. | ||
650 | 4 | |a COVID-19 | |
650 | 4 | |a Mortality | |
653 | 0 | |a Infectious and parasitic diseases | |
700 | 0 | |a Besmir Nreu |e verfasserin |4 aut | |
700 | 0 | |a Matteo Monami |e verfasserin |4 aut | |
773 | 0 | 8 | |i In |t International Journal of Infectious Diseases |d Elsevier, 2015 |g 98(2020), Seite 121-124 |w (DE-627)DOAJ000043923 |x 18783511 |7 nnns |
773 | 1 | 8 | |g volume:98 |g year:2020 |g pages:121-124 |
856 | 4 | 0 | |u https://doi.org/10.1016/j.ijid.2020.06.077 |z kostenfrei |
856 | 4 | 0 | |u https://doaj.org/article/0f105fc96bbb419e92a842d280f75a99 |z kostenfrei |
856 | 4 | 0 | |u http://www.sciencedirect.com/science/article/pii/S1201971220305105 |z kostenfrei |
856 | 4 | 2 | |u https://doaj.org/toc/1201-9712 |y Journal toc |z kostenfrei |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_DOAJ | ||
951 | |a AR | ||
952 | |d 98 |j 2020 |h 121-124 |