New Hydroquinone Monoterpenoid and Cembranoid-Related Metabolites from the Soft Coral <i<Sarcophyton tenuispiculatum</i<
Chemical investigation of the marine soft coral <i<Sarcophyton tenuispiculatum</i< resulted in the isolation of a 1,4-dihydrobenzoquinone, sarcotenuhydroquinone (<b<1</b<), three new cembranoids, sarcotenusenes A‒C (<b<2</b<‒<b<4</b<), and ten previously reported metabolites <b<5</b<–<b<14</b<. The chemical structures of all isolated metabolites were determined by detailed spectroscopic analyses. In biological assays, anti-inflammatory, cytotoxic, and peroxisome proliferator-activated receptor γ (PPAR-γ) transcription factor assays of all compounds were performed. None of the isolated compounds were found to exhibit activity in the PPAR-γ transcription factor assay. The anti-inflammatory assays showed that (+)-7<i<α</i<,8<i<β</i<-dihydroxydeepoxysarcophine (<b<13</b<) inhibited the production of IL-1<i<β</i< to 56 ± 1% at a concentration of 30 <i<µ</i<M in lipopolysaccharide (LPS)-stimulated J774A.1 macrophage cells. In addition, <b<1</b< and <b<2</b< were found to exhibit cytotoxicity towards a panel of cancer cell lines..
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:19 |
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| Enthalten in: |
Marine Drugs - 19(2020), 1, p 8 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Tzu-Yin Huang [VerfasserIn] |
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| Links: |
doi.org [kostenfrei] |
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| Themen: |
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| doi: |
10.3390/md19010008 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
DOAJ034171703 |
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| 520 | |a Chemical investigation of the marine soft coral <i<Sarcophyton tenuispiculatum</i< resulted in the isolation of a 1,4-dihydrobenzoquinone, sarcotenuhydroquinone (<b<1</b<), three new cembranoids, sarcotenusenes A‒C (<b<2</b<‒<b<4</b<), and ten previously reported metabolites <b<5</b<–<b<14</b<. The chemical structures of all isolated metabolites were determined by detailed spectroscopic analyses. In biological assays, anti-inflammatory, cytotoxic, and peroxisome proliferator-activated receptor γ (PPAR-γ) transcription factor assays of all compounds were performed. None of the isolated compounds were found to exhibit activity in the PPAR-γ transcription factor assay. The anti-inflammatory assays showed that (+)-7<i<α</i<,8<i<β</i<-dihydroxydeepoxysarcophine (<b<13</b<) inhibited the production of IL-1<i<β</i< to 56 ± 1% at a concentration of 30 <i<µ</i<M in lipopolysaccharide (LPS)-stimulated J774A.1 macrophage cells. In addition, <b<1</b< and <b<2</b< were found to exhibit cytotoxicity towards a panel of cancer cell lines. | ||
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