Synthesis of N'-(Quinazolin-4-yl)isonicotinohydrazides and their biological screening, docking and ADME studies
A wide range of 4-chloro-3,4-dihydroquinazolines hybrid isoniazid derivatives were synthesised efficiently via reaction of 4-chloro-3,4-dihydroquinazolines with isoniazid in the presence of catalytic amount of N,N-diisopropylethylamine (DIPEA) under refluxing methanol. All the title molecules were characterized by 13C NMR, 1H NMR, Mass and IR spectroscopy. All the compounds were tested for anti-malarial, anti-microbial and anti-tuberculosis activities. They were further tested for the cytotoxic feature. In-silico molecular docking study and ADME properties were also studied for the title molecules. Keywords: Molecular hybridization, Anti-malarial, Anti-microbial, Anti-tuberculosis, MTT assay, Docking, ADME.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:13 |
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| Enthalten in: |
Arabian Journal of Chemistry - 13(2020), 1, Seite 1986-2000 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Kinjal D. Patel [VerfasserIn] |
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| Links: |
doi.org [kostenfrei] |
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| Themen: |
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| doi: |
10.1016/j.arabjc.2018.02.017 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
DOAJ031958559 |
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| 520 | |a A wide range of 4-chloro-3,4-dihydroquinazolines hybrid isoniazid derivatives were synthesised efficiently via reaction of 4-chloro-3,4-dihydroquinazolines with isoniazid in the presence of catalytic amount of N,N-diisopropylethylamine (DIPEA) under refluxing methanol. All the title molecules were characterized by 13C NMR, 1H NMR, Mass and IR spectroscopy. All the compounds were tested for anti-malarial, anti-microbial and anti-tuberculosis activities. They were further tested for the cytotoxic feature. In-silico molecular docking study and ADME properties were also studied for the title molecules. Keywords: Molecular hybridization, Anti-malarial, Anti-microbial, Anti-tuberculosis, MTT assay, Docking, ADME | ||
| 653 | 0 | |a Chemistry | |
| 700 | 0 | |a Rajesh H. Vekariya |e verfasserin |4 aut | |
| 700 | 0 | |a Neelam P. Prajapati |e verfasserin |4 aut | |
| 700 | 0 | |a Dhaval B. Patel |e verfasserin |4 aut | |
| 700 | 0 | |a Hitesh D. Patel |e verfasserin |4 aut | |
| 700 | 0 | |a Tauhid Shaikh |e verfasserin |4 aut | |
| 700 | 0 | |a Dhanji P. Rajani |e verfasserin |4 aut | |
| 700 | 0 | |a Smita Rajani |e verfasserin |4 aut | |
| 700 | 0 | |a Naumita S. Shah |e verfasserin |4 aut | |
| 700 | 0 | |a Devendrasinh Jhala |e verfasserin |4 aut | |
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