A novel aged mouse model of recurrent intracerebral hemorrhage in the bilateral striatum
The current animal models of stroke primarily model a single intracerebral hemorrhage (ICH) attack, and there is a lack of a reliable model of recurrent ICH. In this study, we established 16-month-old C57BL/6 male mouse models of ICH by injecting collagenase VII-S into the left striatum. Twenty-one days later, we injected collagenase VII-S into the right striatum to simulate recurrent ICH. Our results showed that mice subjected to bilateral striatal hemorrhage had poorer neurological function at the early stage of hemorrhage, delayed recovery in locomotor function, motor coordination, and movement speed, and more obvious emotional and cognitive dysfunction than mice subjected to unilateral striatal hemorrhage. These findings indicate that mouse models of bilateral striatal hemorrhage can well simulate clinically common recurrent ICH. These models should be used as a novel tool for investigating the pathogenesis and treatment targets of recurrent ICH..
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:18 |
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| Enthalten in: |
Neural Regeneration Research - 18(2023), 2, Seite 344-349 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Li-Min Wang [VerfasserIn] |
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| Links: |
doi.org [kostenfrei] |
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| doi: |
10.4103/1673-5374.346459 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
DOAJ028268407 |
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| 245 | 1 | 2 | |a A novel aged mouse model of recurrent intracerebral hemorrhage in the bilateral striatum |
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| 520 | |a The current animal models of stroke primarily model a single intracerebral hemorrhage (ICH) attack, and there is a lack of a reliable model of recurrent ICH. In this study, we established 16-month-old C57BL/6 male mouse models of ICH by injecting collagenase VII-S into the left striatum. Twenty-one days later, we injected collagenase VII-S into the right striatum to simulate recurrent ICH. Our results showed that mice subjected to bilateral striatal hemorrhage had poorer neurological function at the early stage of hemorrhage, delayed recovery in locomotor function, motor coordination, and movement speed, and more obvious emotional and cognitive dysfunction than mice subjected to unilateral striatal hemorrhage. These findings indicate that mouse models of bilateral striatal hemorrhage can well simulate clinically common recurrent ICH. These models should be used as a novel tool for investigating the pathogenesis and treatment targets of recurrent ICH. | ||
| 650 | 4 | |a animal model; cognition impairment; depression-like behavior; dopaminergic neurons; emotion; intracerebral hemorrhage; motor; neurologic function; recurrent intracerebral hemorrhage | |
| 653 | 0 | |a Neurology. Diseases of the nervous system | |
| 700 | 0 | |a Zhi-Hua Liu |e verfasserin |4 aut | |
| 700 | 0 | |a Hong-Lei Ren |e verfasserin |4 aut | |
| 700 | 0 | |a Xue-Mei Chen |e verfasserin |4 aut | |
| 700 | 0 | |a Jun-Min Wang |e verfasserin |4 aut | |
| 700 | 0 | |a Hui-Min Cai |e verfasserin |4 aut | |
| 700 | 0 | |a Li-Ping Wei |e verfasserin |4 aut | |
| 700 | 0 | |a Hui-Hong Tian |e verfasserin |4 aut | |
| 700 | 0 | |a Jian Wang |e verfasserin |4 aut | |
| 700 | 0 | |a Li-Juan Wang |e verfasserin |4 aut | |
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