Granulomatosis with polyangiitis diagnosed during the treatment of otitis media with prednisolone in a patient with anti-neutrophil cytoplasmic antibody-associated vasculitis: A case report
A 78-year-old woman with severe auditory disturbance was referred to our hospital and was diagnosed with otitis media with anti-neutrophil cytoplasmic antibody -associated vasculitis (OMAAV). The auditory disturbance improved moderately with prednisolone 40 mg/day, but multiple pulmonary masses were detected on chest computed tomography six months later. Transbronchial lung biopsy revealed granulomatosis with polyangiitis (GPA). Administration of prednisolone 50 mg/day and cyclophosphamide 500 mg once every two weeks for 12 weeks improved the lung lesions, but no further improvement in the hearing ability was observed. Prednisolone monotherapy was not able to prevent progression of OMAAV to GPA..
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:40 |
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| Enthalten in: |
Respiratory Medicine Case Reports - 40(2022), Seite 101771- |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Hirokazu Tokuyasu [VerfasserIn] |
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| Links: |
doi.org [kostenfrei] |
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| doi: |
10.1016/j.rmcr.2022.101771 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
DOAJ026515598 |
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| 520 | |a A 78-year-old woman with severe auditory disturbance was referred to our hospital and was diagnosed with otitis media with anti-neutrophil cytoplasmic antibody -associated vasculitis (OMAAV). The auditory disturbance improved moderately with prednisolone 40 mg/day, but multiple pulmonary masses were detected on chest computed tomography six months later. Transbronchial lung biopsy revealed granulomatosis with polyangiitis (GPA). Administration of prednisolone 50 mg/day and cyclophosphamide 500 mg once every two weeks for 12 weeks improved the lung lesions, but no further improvement in the hearing ability was observed. Prednisolone monotherapy was not able to prevent progression of OMAAV to GPA. | ||
| 650 | 4 | |a Endobronchial ultrasonography with a guide-sheath | |
| 650 | 4 | |a Anti-neutrophil cytoplasmic antibody | |
| 650 | 4 | |a Granulomatosis with polyangiitis | |
| 650 | 4 | |a Non-tuberculous mycobacteria-associated pulmonary disease | |
| 650 | 4 | |a Otitis media with anti-neutrophil cytoplasmic antibody-associated vasculitis | |
| 653 | 0 | |a Diseases of the respiratory system | |
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| 700 | 0 | |a Yuriko Sueda |e verfasserin |4 aut | |
| 700 | 0 | |a Hiromitsu Sakai |e verfasserin |4 aut | |
| 700 | 0 | |a Natsumi Omura-Tanaka |e verfasserin |4 aut | |
| 700 | 0 | |a Hiroshi Miura |e verfasserin |4 aut | |
| 700 | 0 | |a Ryota Okazaki |e verfasserin |4 aut | |
| 700 | 0 | |a Akira Yamasaki |e verfasserin |4 aut | |
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