Generation Z in Non-Fermenters: A Retrospective Evaluation of the Last 12 Years

Introduction: Advances in diagnostic methods in microbiology and the increased prevalence of the fragile and critically ill patient groups in the community and hospitals have increased the frequency of infections caused by unexpected non-fermenter gram-negative bacilli with low virulence. Materials and Methods: This study aimed to determine the distribution and resistance rates of rare non-fermentative gram-negative bacilli isolated from the bacteriology laboratory of our hospitals between January 2010 and November 2021. In addition, proportional analyzes of the patients from whom the bacteria were isolated were made according to the sample type, age groups, gender, and hospital department. Results: 522 non-fermentative gram-negative bacilli were included in our study. It has been determined that isolation rates have increased approximately two times after 2019. When we examined bacteria distribution, 72% (n= 376) of the strains mainly were Achromobacter spp., Aeromonas spp. , Alcaligenes spp. and Sphingomonas paucimobilis species. It was determined that most of the patients in whom these bacteria were isolated were male (65%) and elderly (75%). When the distribution of the departments where the patients were hospitalized was examined, intensive care units took first place with 24%, and hematology/oncology units took second place with 19%. The strains were mainly isolated from the blood (n= 171), followed by wound and abscess samples (n= 145). It has been determined that the antibiotic susceptibility profiles of the strains vary between species. When the results were evaluated by excluding the intrinsic resistant ones, it was determined that the strains had serious resistance rates against aminoglycoside, quinolone, cephalosporin, and piperacillin-tazobactam group antibiotics. It was determined that carbapenem and trimethoprim-sulfamethoxazole susceptibilities were better than others, but after 2019, there was an increase in the number of carbapenem-resistant isolates. Conclusion: Accurate identification at the species level is crucial in the fight against infections caused by these rare non-fermentative bacilli. Another critical step is to perform and evaluate these isolates antibiotic susceptibility tests (AST) with standardized methods. However, standards have not been set in the AST of many of these of bacteria. Antibiotic susceptibility tests application and evaluation criteria for rare non-fermenters should be determined urgently and included in the guidelines..

Medienart:	E-Artikel

Erscheinungsjahr:	2022
Erschienen:	2022

Enthalten in:	Zur Gesamtaufnahme - volume:27
Enthalten in:	Flora Infeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi - 27(2022), 1, Seite 74-86

Sprache:	Englisch ; Türkisch

Beteiligte Personen:	Pınar SAĞIROĞLU [VerfasserIn] Mustafa Altay ATALAY [VerfasserIn]

Links:	doi.org [kostenfrei] doaj.org [kostenfrei] floradergisi.org [kostenfrei] Journal toc [kostenfrei] Journal toc [kostenfrei]

Themen:	Achromobacter Aeromonas Infectious and parasitic diseases Microbiology Non-fermenter Rare infection Resistance

doi:	10.5578/flora.20223030

funding:
Förderinstitution / Projekttitel:

PPN (Katalog-ID):	DOAJ026326973