Raised platelet thiobarbituric acid-reacting substances in proliferative Eales′ disease.
BACKGROUND: Platelets are an elective site for oxidative stress owing to their high content of polyunsaturated fatty acid. Increased lipid peroxidation and elevated platelet thiobarbituric acid-reacting substances (TBARS) signal oxidative stress. This possibly leads to retinal neovascularization in Eales′ disease. METHODS: TBARS levels were estimated in consecutive cases of Eales′ disease with neovascularisation (n = 26), Eales′ disease without neovascularisation (n = 17) and healthy controls (n = 17). RESULTS: Platelet TBARS levels in the cases of Eales′ disease with neovascularisation, Eales′ disease without neovascularisation, and healthy controls were 0.66 +/- 0.1, 0.57 +/- 0.11 and 0.42 +/- 0.14 n moles TBARS formed/hour/10(8) platelets respectively. Student′s t-test showed a significant increase in platelet TBARS levels in cases with neovascularisation as compared to cases without neovascularization (p < 0.05) and healthy controls (p < 0.01). CONCLUSION: The increase in platelet TBARS levels in proliferative Eales′ disease is consistent with an emerging view that lipid peroxides may be associated with retinal neovascularisation..
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2000 |
|---|---|
| Erschienen: |
2000 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:48 |
|---|---|
| Enthalten in: |
Indian Journal of Ophthalmology - 48(2000), 4, Seite 307-9 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Srivastava Prachi [VerfasserIn] |
|---|
| Links: |
doaj.org [kostenfrei] |
|---|
| Themen: |
Adolescent |
|---|
| Förderinstitution / Projekttitel: |
|
|---|
| PPN (Katalog-ID): |
DOAJ025071408 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | DOAJ025071408 | ||
| 003 | DE-627 | ||
| 005 | 20230307082912.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 230226s2000 xx |||||o 00| ||eng c | ||
| 035 | |a (DE-627)DOAJ025071408 | ||
| 035 | |a (DE-599)DOAJ626aeb6331734de1be0c4af8f2b10a46 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 050 | 0 | |a RE1-994 | |
| 100 | 0 | |a Srivastava Prachi |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Raised platelet thiobarbituric acid-reacting substances in proliferative Eales′ disease. |
| 264 | 1 | |c 2000 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 520 | |a BACKGROUND: Platelets are an elective site for oxidative stress owing to their high content of polyunsaturated fatty acid. Increased lipid peroxidation and elevated platelet thiobarbituric acid-reacting substances (TBARS) signal oxidative stress. This possibly leads to retinal neovascularization in Eales′ disease. METHODS: TBARS levels were estimated in consecutive cases of Eales′ disease with neovascularisation (n = 26), Eales′ disease without neovascularisation (n = 17) and healthy controls (n = 17). RESULTS: Platelet TBARS levels in the cases of Eales′ disease with neovascularisation, Eales′ disease without neovascularisation, and healthy controls were 0.66 +/- 0.1, 0.57 +/- 0.11 and 0.42 +/- 0.14 n moles TBARS formed/hour/10(8) platelets respectively. Student′s t-test showed a significant increase in platelet TBARS levels in cases with neovascularisation as compared to cases without neovascularization (p < 0.05) and healthy controls (p < 0.01). CONCLUSION: The increase in platelet TBARS levels in proliferative Eales′ disease is consistent with an emerging view that lipid peroxides may be associated with retinal neovascularisation. | ||
| 650 | 4 | |a Adolescent | |
| 650 | 4 | |a Adult | |
| 650 | 4 | |a Biological Markers | |
| 650 | 4 | |a blood | |
| 650 | 4 | |a Blood Platelets | |
| 650 | 4 | |a metabolism | |
| 650 | 4 | |a Comparative Study | |
| 650 | 4 | |a Disease Progression | |
| 650 | 4 | |a Humans | |
| 650 | 4 | |a Lipid Peroxidation | |
| 650 | 4 | |a ph | |
| 653 | 0 | |a Ophthalmology | |
| 700 | 0 | |a Saxena Sandeep |e verfasserin |4 aut | |
| 700 | 0 | |a Khanna Vinay |e verfasserin |4 aut | |
| 700 | 0 | |a Kumar Dipak |e verfasserin |4 aut | |
| 700 | 0 | |a Nath Rajiv |e verfasserin |4 aut | |
| 700 | 0 | |a Seth Prahlad |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i In |t Indian Journal of Ophthalmology |d Wolters Kluwer Medknow Publications, 2005 |g 48(2000), 4, Seite 307-9 |w (DE-627)DOAJ000058459 |x 19983689 |7 nnns |
| 773 | 1 | 8 | |g volume:48 |g year:2000 |g number:4 |g pages:307-9 |
| 856 | 4 | 0 | |u https://doaj.org/article/626aeb6331734de1be0c4af8f2b10a46 |z kostenfrei |
| 856 | 4 | 0 | |u http://www.ijo.in/article.asp?issn=0301-4738;year=2000;volume=48;issue=4;spage=307;epage=9;aulast=Srivastava |z kostenfrei |
| 856 | 4 | 2 | |u https://doaj.org/toc/0301-4738 |y Journal toc |z kostenfrei |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_DOAJ | ||
| 951 | |a AR | ||
| 952 | |d 48 |j 2000 |e 4 |h 307-9 | ||