Nesfatin Level and Correlation of Nesfatin with Troponin and CRP in Patients with Myocardial Infarction

Aim: Myocardial infarction (MI) is one of the main causes of cardiovascular disease-related mortality and morbidity. Acute thrombosis resulting from atherosclerotic plaque rupture is the most important cause. Nesfatin, which is effective in food intake and energy homeostasis, is one of the markers investigated. In our study, we aimed to determine the relationship between myocardial infarction and nesfatin level. We also planned to explain the relationship between nesfatin level and troponin and CRP. Method: Newly diagnosed patients with acute coronary syndrome (ACS) who underwent coronary angiography were included in our study, which was approved by the ethics committee. Those with obesity, chronic kidney disease, diabetes mellitus were excluded. The control group included 60 patients whose troponin levels did not increase and who had normal coronary anatomy. In the MI group, 59 MI patients who underwent primary percutaneous intervention due to <2 mm st segment elevation on the admission ECG were evaluated. Demographic information, hemogram, serum nesfatin, troponin, c-reactive protein (CRP), lipid panel and other routine biochemical parameters were evaluated in all patients. Results: Troponin, LDL, CRP, WBC values were significantly higher in the MI group (p<0.001). Nesfatin values were found to be significantly lower than the control group (p<0.001). It was observed that male gender predominated in the MI group. In the correlation analysis of the data in the MI group, no significant positive or negative correlation was found between nesfatin and troponin, lipid profile, CRP and WBC. Conclusion: In our study, it was shown that low serum nesfatin levels may be associated with MI and it was supported that it could be one of the etiopathogenetic reasons. No correlation was found with increased troponin, LDL, CRP and WBC levels. This relationship was not supportive in terms of inflammatory properties and prognosis of the disease..

Medienart:	E-Artikel

Erscheinungsjahr:	2022
Erschienen:	2022

Enthalten in:	Zur Gesamtaufnahme - volume:49
Enthalten in:	Dicle Medical Journal - 49(2022), 4, Seite 692-698

Sprache:	Englisch ; Türkisch

Beteiligte Personen:	Mehmet Şahin Adıyaman [VerfasserIn] Revşa Evin Canpolat Erkan [VerfasserIn] İlyas Kaya [VerfasserIn] Özlem Aba Adıyaman [VerfasserIn]

Links:	doi.org [kostenfrei] doaj.org [kostenfrei] diclemedj.org [kostenfrei] Journal toc [kostenfrei]

Themen:	Crp Medicine Medicine (General) Myocardial infarction Nesfatin R Troponin.

doi:	10.5798/dicletip.1220948

funding:
Förderinstitution / Projekttitel:

PPN (Katalog-ID):	DOAJ020742770