Pleiotropic Roles of CXCR4 in Wound Repair and Regeneration
Wound healing is a multi-step process that includes multiple cellular events such as cell proliferation, cell adhesion, and chemotactic response as well as cell apoptosis. Accumulating studies have documented the significance of stromal cell-derived factor-1 (SDF-1)/C-X-C chemokine receptor 4 (CXCR4) signaling in wound repair and regeneration. However, the molecular mechanism of regeneration is not clear. This review describes various types of tissue regeneration that CXCR4 participates in and how the efficiency of regeneration is increased by CXCR4 overexpression. It emphasizes the pleiotropic effects of CXCR4 in regeneration. By delving into the specific molecular mechanisms of CXCR4, we hope to provide a theoretical basis for tissue engineering and future regenerative medicine..
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2021 |
|---|---|
| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:12 |
|---|---|
| Enthalten in: |
Frontiers in Immunology - 12(2021) |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Huating Chen [VerfasserIn] |
|---|
| Links: |
doi.org [kostenfrei] |
|---|
| Themen: |
Adhesion |
|---|
| doi: |
10.3389/fimmu.2021.668758 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
DOAJ020125801 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | DOAJ020125801 | ||
| 003 | DE-627 | ||
| 005 | 20230310114604.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 230226s2021 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.3389/fimmu.2021.668758 |2 doi | |
| 035 | |a (DE-627)DOAJ020125801 | ||
| 035 | |a (DE-599)DOAJ1390dbdcb36c4255983729e38324f6c8 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 050 | 0 | |a RC581-607 | |
| 100 | 0 | |a Huating Chen |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Pleiotropic Roles of CXCR4 in Wound Repair and Regeneration |
| 264 | 1 | |c 2021 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 520 | |a Wound healing is a multi-step process that includes multiple cellular events such as cell proliferation, cell adhesion, and chemotactic response as well as cell apoptosis. Accumulating studies have documented the significance of stromal cell-derived factor-1 (SDF-1)/C-X-C chemokine receptor 4 (CXCR4) signaling in wound repair and regeneration. However, the molecular mechanism of regeneration is not clear. This review describes various types of tissue regeneration that CXCR4 participates in and how the efficiency of regeneration is increased by CXCR4 overexpression. It emphasizes the pleiotropic effects of CXCR4 in regeneration. By delving into the specific molecular mechanisms of CXCR4, we hope to provide a theoretical basis for tissue engineering and future regenerative medicine. | ||
| 650 | 4 | |a CXCR4 | |
| 650 | 4 | |a wound healing | |
| 650 | 4 | |a inflammation | |
| 650 | 4 | |a proliferation | |
| 650 | 4 | |a adhesion | |
| 650 | 4 | |a chemotaxis | |
| 653 | 0 | |a Immunologic diseases. Allergy | |
| 700 | 0 | |a Huating Chen |e verfasserin |4 aut | |
| 700 | 0 | |a Gongchi Li |e verfasserin |4 aut | |
| 700 | 0 | |a Yiqiong Liu |e verfasserin |4 aut | |
| 700 | 0 | |a Shuaifei Ji |e verfasserin |4 aut | |
| 700 | 0 | |a Yan Li |e verfasserin |4 aut | |
| 700 | 0 | |a Yan Li |e verfasserin |4 aut | |
| 700 | 0 | |a Jiangbing Xiang |e verfasserin |4 aut | |
| 700 | 0 | |a Jiangbing Xiang |e verfasserin |4 aut | |
| 700 | 0 | |a Laixian Zhou |e verfasserin |4 aut | |
| 700 | 0 | |a Huanhuan Gao |e verfasserin |4 aut | |
| 700 | 0 | |a Wenwen Zhang |e verfasserin |4 aut | |
| 700 | 0 | |a Xiaoyan Sun |e verfasserin |4 aut | |
| 700 | 0 | |a Xiaobing Fu |e verfasserin |4 aut | |
| 700 | 0 | |a Binghui Li |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i In |t Frontiers in Immunology |d Frontiers Media S.A., 2011 |g 12(2021) |w (DE-627)DOAJ000031690 |x 16643224 |7 nnns |
| 773 | 1 | 8 | |g volume:12 |g year:2021 |
| 856 | 4 | 0 | |u https://doi.org/10.3389/fimmu.2021.668758 |z kostenfrei |
| 856 | 4 | 0 | |u https://doaj.org/article/1390dbdcb36c4255983729e38324f6c8 |z kostenfrei |
| 856 | 4 | 0 | |u https://www.frontiersin.org/articles/10.3389/fimmu.2021.668758/full |z kostenfrei |
| 856 | 4 | 2 | |u https://doaj.org/toc/1664-3224 |y Journal toc |z kostenfrei |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_DOAJ | ||
| 951 | |a AR | ||
| 952 | |d 12 |j 2021 | ||