Microglia and mast cells: new targets for the treatment of chronic pain
The article is devoted to the problem of effective management of chronic pain. A review of the known mechanisms of development and maintenance of chronic pain and possible methods of influence is given. One of the reasons for the lack of chronic pain treatment effectiveness in some patients is the use of treatment regimens with drugs acting exclusively on the targets located in the nerve structures. Today an important role of microglia and mast cells in the development and maintenance of chronic pain conditions is well acknowledged. A new class of drugs from the group of acylethanolamides is described. One of the representatives of this group is palmitoylethanolamide. This drug may modulate the activity of microglia and mast cells, thus increasing the pain threshold and the effectiveness of therapy. The use of palmitoylethanolamide in patients with chronic pain can increase the effectiveness of therapy..
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:11 |
|---|---|
| Enthalten in: |
Bolʹ, Sustavy, Pozvonočnik - 11(2021), 2, Seite 79-85 |
| Sprache: |
Englisch ; Ukrainisch |
|---|
| Beteiligte Personen: |
V.I. Romanenko [VerfasserIn] |
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| Links: |
doi.org [kostenfrei] |
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| Themen: |
Chronic pain, microglia, palmitoylethanolamide |
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| doi: |
10.22141/2224-1507.11.2.2021.236566 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
DOAJ01801352X |
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