Prevention of reperfusion lung injury by lidocaine in isolated rat lung ventilated with higher oxygen levels.
BACKGROUND: Lidocaine, an antiarrhythmic drug has been shown to be effective against post-ischaemic reperfusion injury in heart. However, its effect on pulmonary reperfusion injury has not been investigated. AIMS: We investigated the effects of lidocaine on a postischaemic reperfused rat lung model. MATERIALS AND METHODS: Lungs were isolated and perfused at constant flow with Krebs-Henseilet buffer containing 4% bovine serum albumin, and ventilated with 95% oxygen mixed with 5% CO2. Lungs were subjected to ischaemia by stopping perfusion for 60 minutes followed by reperfusion for 10 minutes. Ischaemia was induced in normothermic conditions. RESULTS: Postischaemic reperfusion caused significant (p < 0.0001) higher wet-to-dry lung weight ratio, pulmonary arterial pressure and peak airway pressure compared to control lungs. Lidocaine, at a dose of 5mg/Kg b.w. was found to significantly (p < 0.0001) attenuate the increase in the wet-to-dry lung weight ratio, pulmonary arterial pressure and peak airway pressure observed in post-ischaemic lungs. CONCLUSION: Lidocaine is effective in preventing post-ischaemic reperfusion injury in isolated, perfused rat lung..
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2003 |
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| Erschienen: |
2003 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:49 |
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| Enthalten in: |
Journal of Postgraduate Medicine - 49(2003), 1, Seite 17-20 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
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| Links: |
doaj.org [kostenfrei] |
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| Themen: |
Administration & dosage |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
DOAJ016459946 |
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| 245 | 1 | 0 | |a Prevention of reperfusion lung injury by lidocaine in isolated rat lung ventilated with higher oxygen levels. |
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| 520 | |a BACKGROUND: Lidocaine, an antiarrhythmic drug has been shown to be effective against post-ischaemic reperfusion injury in heart. However, its effect on pulmonary reperfusion injury has not been investigated. AIMS: We investigated the effects of lidocaine on a postischaemic reperfused rat lung model. MATERIALS AND METHODS: Lungs were isolated and perfused at constant flow with Krebs-Henseilet buffer containing 4% bovine serum albumin, and ventilated with 95% oxygen mixed with 5% CO2. Lungs were subjected to ischaemia by stopping perfusion for 60 minutes followed by reperfusion for 10 minutes. Ischaemia was induced in normothermic conditions. RESULTS: Postischaemic reperfusion caused significant (p < 0.0001) higher wet-to-dry lung weight ratio, pulmonary arterial pressure and peak airway pressure compared to control lungs. Lidocaine, at a dose of 5mg/Kg b.w. was found to significantly (p < 0.0001) attenuate the increase in the wet-to-dry lung weight ratio, pulmonary arterial pressure and peak airway pressure observed in post-ischaemic lungs. CONCLUSION: Lidocaine is effective in preventing post-ischaemic reperfusion injury in isolated, perfused rat lung. | ||
| 650 | 4 | |a Animal | |
| 650 | 4 | |a Comparative Study | |
| 650 | 4 | |a Lidocaine | |
| 650 | 4 | |a pharmacology | |
| 650 | 4 | |a Lung | |
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| 650 | 4 | |a Male | |
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| 650 | 4 | |a Oxygen | |
| 650 | 4 | |a administration & dosage | |
| 650 | 4 | |a Rats | |
| 650 | 4 | |a Sprague-Dawley | |
| 650 | 4 | |a Reperfusion Injury | |
| 650 | 4 | |a prevention & control | |
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