Neurosensory dysfunction: A diagnostic marker of early COVID-19
Objective: To describe neurosensory dysfunctions, including hyposmia, hypogeusia, and tinnitus, in patients with COVID-19. Methods: Clinical characteristics and oropharyngeal swabs were obtained from 86 patients with COVID-19 hospitalized in Guangzhou Eighth People’s Hospital. The chronological analysis method was used to detail neurosensory dysfunction. The cycle threshold (Ct) values were used to approximately indicate viral load. Results: Forty-four (51.2%) patients had neurosensory dysfunction: hyposmia (34, 39.5%), hypogeusia (33, 38.4%), and tinnitus (three, 3.5%). Neurosensory dysfunction was significantly more common in patients under 40 years old (p = 0.001) and women (p = 0.006). Hyposmia and hypogeusia coexisted in 23 (26.7%) patients. The interval between onset of hyposmia and hypogeusia was 0.7 ± 1.46 days. The interval from onset of hyposmia and hypogeusia to typical COVID-19 symptoms was 0.22 ± 4.57 and 0.75 ± 6.77 days; the interval from onset of hyposmia and hypogeusia to admission was 6.06 ± 6.68 and 5.76 ± 7.68 days; and the duration of hyposmia and hypogeusia was 9.09 ± 5.74 and 7.12 ± 4.66 days, respectively. The viral load was high following symptoms onset, peaked within the first week, and gradually declined. Conclusions: Neurosensory dysfunction tends to occur in the early stage of COVID-19, and it could be used as a marker for the early diagnosis of COVID-19..
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:98 |
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| Enthalten in: |
International Journal of Infectious Diseases - 98(2020), Seite 347-352 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Yujie Liang [VerfasserIn] |
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| Links: |
doi.org [kostenfrei] |
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| Themen: |
COVID-19 |
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| doi: |
10.1016/j.ijid.2020.06.086 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
DOAJ016285433 |
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| 520 | |a Objective: To describe neurosensory dysfunctions, including hyposmia, hypogeusia, and tinnitus, in patients with COVID-19. Methods: Clinical characteristics and oropharyngeal swabs were obtained from 86 patients with COVID-19 hospitalized in Guangzhou Eighth People’s Hospital. The chronological analysis method was used to detail neurosensory dysfunction. The cycle threshold (Ct) values were used to approximately indicate viral load. Results: Forty-four (51.2%) patients had neurosensory dysfunction: hyposmia (34, 39.5%), hypogeusia (33, 38.4%), and tinnitus (three, 3.5%). Neurosensory dysfunction was significantly more common in patients under 40 years old (p = 0.001) and women (p = 0.006). Hyposmia and hypogeusia coexisted in 23 (26.7%) patients. The interval between onset of hyposmia and hypogeusia was 0.7 ± 1.46 days. The interval from onset of hyposmia and hypogeusia to typical COVID-19 symptoms was 0.22 ± 4.57 and 0.75 ± 6.77 days; the interval from onset of hyposmia and hypogeusia to admission was 6.06 ± 6.68 and 5.76 ± 7.68 days; and the duration of hyposmia and hypogeusia was 9.09 ± 5.74 and 7.12 ± 4.66 days, respectively. The viral load was high following symptoms onset, peaked within the first week, and gradually declined. Conclusions: Neurosensory dysfunction tends to occur in the early stage of COVID-19, and it could be used as a marker for the early diagnosis of COVID-19. | ||
| 650 | 4 | |a Neurosensory dysfunction | |
| 650 | 4 | |a COVID-19 | |
| 650 | 4 | |a Hyposmia | |
| 650 | 4 | |a Hypogeusia | |
| 650 | 4 | |a Diagnosis | |
| 653 | 0 | |a Infectious and parasitic diseases | |
| 700 | 0 | |a Jiabin Xu |e verfasserin |4 aut | |
| 700 | 0 | |a Mei Chu |e verfasserin |4 aut | |
| 700 | 0 | |a Jianbo Mai |e verfasserin |4 aut | |
| 700 | 0 | |a Niangmei Lai |e verfasserin |4 aut | |
| 700 | 0 | |a Wen Tang |e verfasserin |4 aut | |
| 700 | 0 | |a Tuanjie Yang |e verfasserin |4 aut | |
| 700 | 0 | |a Sien Zhang |e verfasserin |4 aut | |
| 700 | 0 | |a Chenyu Guan |e verfasserin |4 aut | |
| 700 | 0 | |a Fan Zhong |e verfasserin |4 aut | |
| 700 | 0 | |a Liuping Yang |e verfasserin |4 aut | |
| 700 | 0 | |a Guiqing Liao |e verfasserin |4 aut | |
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