Synthesis and Bioinformatic Characterization of New Schiff Bases with Possible Applicability in Brain Disorders
(1) Background: The research aims to find new treatments for neurodegenerative diseases, in particular, Alzheimer’s disease. (2) Methods: This article presents a bioinformatics and pathology study of new Schiff bases, (<i<EZ</i<)-N′-benzylidene-(2<i<RS</i<)-2-(6-chloro-9<i<H</i<-carbazol-2-yl)propanehydrazide derivatives, and aims to evaluate the drug-like, pharmacokinetic, pharmacodynamic and pharmacogenomic properties, as well as to predict the binding to therapeutic targets by applying bioinformatics, cheminformatics and computational pharmacological methods. (3) Results: We obtained these Schiff bases by condensing (2<i<RS</i<)-2-(6-chloro-9<i<H</i<-carbazol-2-yl)propanehydrazide with aromatic aldehydes, using the advantages of microwave irradiation. The newly synthesized compounds were characterized spectrally, using FT-IR and NMR spectroscopy, which confirmed their structure. Using bioinformatics tools, we noticed that all new compounds are drug-likeness features and may be proposed as potentially neuropsychiatric drugs (4) Conclusions: Using bioinformatics tools, we determined that the new compound <b<1e</b< had a high potential to be used as a good candidate in neurodegenerative disorders treatment..
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:26 |
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| Enthalten in: |
Molecules - 26(2021), 14, p 4160 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Speranta Avram [VerfasserIn] |
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| Links: |
doi.org [kostenfrei] |
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| Themen: |
Bioinformatics |
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| doi: |
10.3390/molecules26144160 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
DOAJ01599502X |
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| 520 | |a (1) Background: The research aims to find new treatments for neurodegenerative diseases, in particular, Alzheimer’s disease. (2) Methods: This article presents a bioinformatics and pathology study of new Schiff bases, (<i<EZ</i<)-N′-benzylidene-(2<i<RS</i<)-2-(6-chloro-9<i<H</i<-carbazol-2-yl)propanehydrazide derivatives, and aims to evaluate the drug-like, pharmacokinetic, pharmacodynamic and pharmacogenomic properties, as well as to predict the binding to therapeutic targets by applying bioinformatics, cheminformatics and computational pharmacological methods. (3) Results: We obtained these Schiff bases by condensing (2<i<RS</i<)-2-(6-chloro-9<i<H</i<-carbazol-2-yl)propanehydrazide with aromatic aldehydes, using the advantages of microwave irradiation. The newly synthesized compounds were characterized spectrally, using FT-IR and NMR spectroscopy, which confirmed their structure. Using bioinformatics tools, we noticed that all new compounds are drug-likeness features and may be proposed as potentially neuropsychiatric drugs (4) Conclusions: Using bioinformatics tools, we determined that the new compound <b<1e</b< had a high potential to be used as a good candidate in neurodegenerative disorders treatment. | ||
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