Concomitant acral necrosis and haemolytic uraemic syndrome following ingestion of quinine.
Thrombotic microangiopathy, which broadly includes thrombotic thrombocytopaenic purpura (TTP) and haemolytic uraemic syndrome (HUS), is a multisystemic disorder that is characterised by thrombocytopaenia, microangiopathic haemolytic anemia and ischaemic manifestations, resulting from platelet agglutination in the arterial microvasculature. Acral necrosis (distal necrosis of fingers and toes) occurs usually as a sequel to severe Raynaud′s phenomenon, a vasculospastic disorder frequently related to endothelial cell dysfunction. We report a case of quinine induced TTP-HUS and acral necrosis, two distinct clinical abnormalities which have not yet been reported together in association with quinine. Both of these conditions in this case resolved promptly to treatment with corticosteroids..
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2002 |
---|---|
Erschienen: |
2002 |
Enthalten in: |
Zur Gesamtaufnahme - volume:48 |
---|---|
Enthalten in: |
Journal of Postgraduate Medicine - 48(2002), 3, Seite 197-8 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Agarwal N [VerfasserIn] |
---|
Links: |
doaj.org [kostenfrei] |
---|
Förderinstitution / Projekttitel: |
|
---|
PPN (Katalog-ID): |
DOAJ011356677 |
---|
LEADER | 01000caa a22002652 4500 | ||
---|---|---|---|
001 | DOAJ011356677 | ||
003 | DE-627 | ||
005 | 20230503013251.0 | ||
007 | cr uuu---uuuuu | ||
008 | 230225s2002 xx |||||o 00| ||eng c | ||
035 | |a (DE-627)DOAJ011356677 | ||
035 | |a (DE-599)DOAJd96bc1716ee6432d84481922cf3b1f37 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 0 | |a Agarwal N |e verfasserin |4 aut | |
245 | 1 | 0 | |a Concomitant acral necrosis and haemolytic uraemic syndrome following ingestion of quinine. |
264 | 1 | |c 2002 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a Computermedien |b c |2 rdamedia | ||
338 | |a Online-Ressource |b cr |2 rdacarrier | ||
520 | |a Thrombotic microangiopathy, which broadly includes thrombotic thrombocytopaenic purpura (TTP) and haemolytic uraemic syndrome (HUS), is a multisystemic disorder that is characterised by thrombocytopaenia, microangiopathic haemolytic anemia and ischaemic manifestations, resulting from platelet agglutination in the arterial microvasculature. Acral necrosis (distal necrosis of fingers and toes) occurs usually as a sequel to severe Raynaud′s phenomenon, a vasculospastic disorder frequently related to endothelial cell dysfunction. We report a case of quinine induced TTP-HUS and acral necrosis, two distinct clinical abnormalities which have not yet been reported together in association with quinine. Both of these conditions in this case resolved promptly to treatment with corticosteroids. | ||
650 | 4 | |a Adrenal Cortex Hormones | |
650 | 4 | |a administration & dosage | |
650 | 4 | |a Aged | |
650 | 4 | |a Biopsy | |
650 | 4 | |a Needle | |
650 | 4 | |a Case Report | |
650 | 4 | |a Follow-Up Studies | |
650 | 4 | |a Hemolytic-Uremic Syndrome | |
650 | 4 | |a chemically induced | |
650 | 4 | |a complications | |
650 | 4 | |a drug therapy | |
650 | 4 | |a pathology | |
650 | 4 | |a Human | |
650 | 4 | |a Immunohistochemistry | |
650 | 4 | |a Male | |
650 | 4 | |a Necrosis | |
650 | 4 | |a Purpura | |
650 | 4 | |a Thrombotic Thrombocytopenic | |
650 | 4 | |a Quinine | |
650 | 4 | |a adverse effects | |
650 | 4 | |a Risk Assessment | |
650 | 4 | |a Toes | |
650 | 4 | |a Treatment Outcome | |
653 | 0 | |a Medicine | |
653 | 0 | |a R | |
700 | 0 | |a Cherascu B |e verfasserin |4 aut | |
773 | 0 | 8 | |i In |t Journal of Postgraduate Medicine |d Wolters Kluwer Medknow Publications, 2003 |g 48(2002), 3, Seite 197-8 |w (DE-627)DOAJ00006470X |x 09722823 |7 nnns |
773 | 1 | 8 | |g volume:48 |g year:2002 |g number:3 |g pages:197-8 |
856 | 4 | 0 | |u https://doaj.org/article/d96bc1716ee6432d84481922cf3b1f37 |z kostenfrei |
856 | 4 | 0 | |u http://www.jpgmonline.com/article.asp?issn=0022-3859;year=2002;volume=48;issue=3;spage=197;epage=8;aulast=Agarwal |z kostenfrei |
856 | 4 | 2 | |u https://doaj.org/toc/0022-3859 |y Journal toc |z kostenfrei |
856 | 4 | 2 | |u https://doaj.org/toc/0972-2823 |y Journal toc |z kostenfrei |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_DOAJ | ||
912 | |a SSG-OLC-PHA | ||
951 | |a AR | ||
952 | |d 48 |j 2002 |e 3 |h 197-8 |