Tuberculous Lymphadenopathy in Adults: A Review of 35 Cases
We followed-up 35 cases (25 female, 10 male, mean age: 33 ± 17 years, range: 16-70) of tuberculous lymphadenopathy (TB LAP) between 1981-2000. We reviewed clinical, radiographic, and laboratory, results as well as diagnostic, therapeutic and prognostic features of the patients retrospectively. The diagnosis of TB LAP was established by the confirmation of tissue histology (in 32), or by the presence of acid-fast bacilli (AFB) in aspirate (in 2) or in sinus drainage (in 1). Paraffin-embedded tissues of granulomatous adenitis were studied for Mycobacterium tuberculosis DNA by polymerase chain reaction (n= 21). During admission, 34% of the patients had enlarging LAP, 9% had draining LAP, and 57% had both enlarging LAP and systemic complaints. The cervical lymph nodes were most frequently involved (77%). Erythrocyte sedimentation rate (ESR) was < 100 mm/hour in 25% of the cases and all of these cases were associated with systemic complaints. Tuberculin skin test was positive in 91% of the cases. AFB could not be seen in granulomas studied (0/21), PCR yielded positive result in 33% (7/21). All the patients were prescribed anti-TB treatment (isoniazid, rifampin, ethambutol, and/or pyrazinamide). Two patients needed surgical excision for their draining lymph nodes in addition to the medical therapy. Clinical improvement was obtained within 3 months, and ESR returned to normal within 5 months. Twenty two patients hod been followed-up for 3 years following the treatment and recurrence was not observed in any. In conclusion, TB LAP is generally presented with painless, small, few and slowly growing lymph nodes. The exact diagnosis should be based on tissue sampling. Anti-TB drugs are essential for the treatment..
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2001 |
|---|---|
| Erschienen: |
2001 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:6 |
|---|---|
| Enthalten in: |
Flora Infeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi - 6(2001), 3, Seite 201-205 |
| Sprache: |
Englisch ; Türkisch |
|---|
| Beteiligte Personen: |
Ali MERT [VerfasserIn] |
|---|
| Links: |
doaj.org [kostenfrei] |
|---|
| Themen: |
Granuloma |
|---|
| Förderinstitution / Projekttitel: |
|
|---|
| PPN (Katalog-ID): |
DOAJ00688704X |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | DOAJ00688704X | ||
| 003 | DE-627 | ||
| 005 | 20230310180905.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 230225s2001 xx |||||o 00| ||eng c | ||
| 035 | |a (DE-627)DOAJ00688704X | ||
| 035 | |a (DE-599)DOAJ7f0f4c35d75c4491a616afbf847f67f5 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng |a tur | ||
| 050 | 0 | |a RC109-216 | |
| 050 | 0 | |a QR1-502 | |
| 100 | 0 | |a Ali MERT |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Tuberculous Lymphadenopathy in Adults: A Review of 35 Cases |
| 264 | 1 | |c 2001 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 520 | |a We followed-up 35 cases (25 female, 10 male, mean age: 33 ± 17 years, range: 16-70) of tuberculous lymphadenopathy (TB LAP) between 1981-2000. We reviewed clinical, radiographic, and laboratory, results as well as diagnostic, therapeutic and prognostic features of the patients retrospectively. The diagnosis of TB LAP was established by the confirmation of tissue histology (in 32), or by the presence of acid-fast bacilli (AFB) in aspirate (in 2) or in sinus drainage (in 1). Paraffin-embedded tissues of granulomatous adenitis were studied for Mycobacterium tuberculosis DNA by polymerase chain reaction (n= 21). During admission, 34% of the patients had enlarging LAP, 9% had draining LAP, and 57% had both enlarging LAP and systemic complaints. The cervical lymph nodes were most frequently involved (77%). Erythrocyte sedimentation rate (ESR) was < 100 mm/hour in 25% of the cases and all of these cases were associated with systemic complaints. Tuberculin skin test was positive in 91% of the cases. AFB could not be seen in granulomas studied (0/21), PCR yielded positive result in 33% (7/21). All the patients were prescribed anti-TB treatment (isoniazid, rifampin, ethambutol, and/or pyrazinamide). Two patients needed surgical excision for their draining lymph nodes in addition to the medical therapy. Clinical improvement was obtained within 3 months, and ESR returned to normal within 5 months. Twenty two patients hod been followed-up for 3 years following the treatment and recurrence was not observed in any. In conclusion, TB LAP is generally presented with painless, small, few and slowly growing lymph nodes. The exact diagnosis should be based on tissue sampling. Anti-TB drugs are essential for the treatment. | ||
| 650 | 4 | |a Tuberculosis | |
| 650 | 4 | |a Lymphadenopathy | |
| 650 | 4 | |a Granuloma | |
| 650 | 4 | |a Polymerase chain reaction | |
| 653 | 0 | |a Infectious and parasitic diseases | |
| 653 | 0 | |a Microbiology | |
| 700 | 0 | |a Fehmi TABAK |e verfasserin |4 aut | |
| 700 | 0 | |a Reşat ÖZARAS |e verfasserin |4 aut | |
| 700 | 0 | |a Recep ÖZTÜRK |e verfasserin |4 aut | |
| 700 | 0 | |a Hilal AKI |e verfasserin |4 aut | |
| 700 | 0 | |a Yıldırım AKTUĞLU |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i In |t Flora Infeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi |d Bilimsel Tip Yayinevi, 2018 |g 6(2001), 3, Seite 201-205 |w (DE-627)DOAJ000080411 |x 1300932X |7 nnns |
| 773 | 1 | 8 | |g volume:6 |g year:2001 |g number:3 |g pages:201-205 |
| 856 | 4 | 0 | |u https://doaj.org/article/7f0f4c35d75c4491a616afbf847f67f5 |z kostenfrei |
| 856 | 4 | 0 | |u http://www.floradergisi.org/getFileContent.aspx?op=REDPDF&file_name=2001-6-3-201-205.pdf |z kostenfrei |
| 856 | 4 | 2 | |u https://doaj.org/toc/1300-932X |y Journal toc |z kostenfrei |
| 856 | 4 | 2 | |u https://doaj.org/toc/1300-932X |y Journal toc |z kostenfrei |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_DOAJ | ||
| 951 | |a AR | ||
| 952 | |d 6 |j 2001 |e 3 |h 201-205 | ||