Investigating the Relationship between Vitamin D and Persistent Symptoms Following SARS-CoV-2 Infection
The emergence of persistent symptoms following SARS-CoV-2 infection, known as <i<long COVID</i<, is providing a new challenge to healthcare systems. The cardinal features are fatigue and reduced exercise tolerance. Vitamin D is known to have pleotropic effects far beyond bone health and is associated with immune modulation and autoimmunity. We hypothesize that vitamin D levels are associated with persistent symptoms following COVID-19. Herein, we investigate the relationship between vitamin D and fatigue and reduced exercise tolerance, assessed by the Chalder Fatigue Score, six-minute walk test and modified Borg scale. Multivariable linear and logistic regression models were used to evaluate the relationships. A total of 149 patients were recruited at a median of 79 days after COVID-19 illness. The median vitamin D level was 62 nmol/L, with <i<n</i< = 36 (24%) having levels 30–49 nmol/L and <i<n</i< = 14 (9%) with levels <30 nmol/L. Fatigue was common, with <i<n</i< = 86 (58%) meeting the case definition. The median Borg score was 3, while the median distance covered for the walk test was 450 m. No relationship between vitamin D and the measures of ongoing ill-health assessed in the study was found following multivariable regression analysis. These results suggest that persistent fatigue and reduced exercise tolerance following COVID-19 are independent of vitamin D..
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:13 |
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| Enthalten in: |
Nutrients - 13(2021), 7, p 2430 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Liam Townsend [VerfasserIn] |
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| Links: |
doi.org [kostenfrei] |
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| Themen: |
Fatigue |
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| doi: |
10.3390/nu13072430 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
DOAJ002467216 |
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| 520 | |a The emergence of persistent symptoms following SARS-CoV-2 infection, known as <i<long COVID</i<, is providing a new challenge to healthcare systems. The cardinal features are fatigue and reduced exercise tolerance. Vitamin D is known to have pleotropic effects far beyond bone health and is associated with immune modulation and autoimmunity. We hypothesize that vitamin D levels are associated with persistent symptoms following COVID-19. Herein, we investigate the relationship between vitamin D and fatigue and reduced exercise tolerance, assessed by the Chalder Fatigue Score, six-minute walk test and modified Borg scale. Multivariable linear and logistic regression models were used to evaluate the relationships. A total of 149 patients were recruited at a median of 79 days after COVID-19 illness. The median vitamin D level was 62 nmol/L, with <i<n</i< = 36 (24%) having levels 30–49 nmol/L and <i<n</i< = 14 (9%) with levels <30 nmol/L. Fatigue was common, with <i<n</i< = 86 (58%) meeting the case definition. The median Borg score was 3, while the median distance covered for the walk test was 450 m. No relationship between vitamin D and the measures of ongoing ill-health assessed in the study was found following multivariable regression analysis. These results suggest that persistent fatigue and reduced exercise tolerance following COVID-19 are independent of vitamin D. | ||
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