The impact on colostrum oxidative stress, cytokines, and immune cells composition after SARS-CoV-2 infection during pregnancy
BackgroundLimited data are available regarding the differences between immunological, biochemical, and cellular contents of human colostrum following maternal infection during pregnancy with coronavirus 2 disease (COVID-19).ObjectiveTo investigate whether maternal COVID-19 infection may affect immunological, biochemical, and cellular contents of human colostrum.MethodsUsing a case-control study design, we collected colostrum from 14 lactating women with a previous diagnosis of COVID-19 during pregnancy and 12 without a clear diagnosis during September 2020 to May 2021. Colostrum samples were analysed for some enzymes and non-enzymatic oxidative stress markers (SOD, CAT, GPx, MDA, GSH, GSSG, H2O2, MPO) and for IL-1β, IL-6, tumour necrosis factor (TNF)-α, protein induced by interferon gamma (IP)-10, IL-8, IFN-λ1, IL12p70, IFN-α2, IFN-λ2/3, granulocyte macrophage colony stimulating factor (GM-CSF), IFN-β, IL-10 and IFN-γ, along with IgA and IgG for the SARS-CoV-2 S protein. We perform immunophenotyping to assess the frequency of different cell types in the colostrum.ResultsColostrum from the COVID-19 symptomatic group in pregnancy contained reduced levels of H2O2, IFN-α2, and GM-CSF. This group had higher levels of GSH, and both NK cell subtypes CD3-CD56brightCD16-CD27+IFN-γ+ and CD3-CD56dimCD16+CD27- were also increased.ConclusionThe present results reinforce the protective role of colostrum even in the case of mild SARS-Cov-2 infection, in addition to demonstrating how adaptive the composition of colostrum is after infections. It also supports the recommendation to encourage lactating women to continue breastfeeding after COVID-19 illness..
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2022 |
---|---|
Erschienen: |
2022 |
Enthalten in: |
Zur Gesamtaufnahme - volume:13 |
---|---|
Enthalten in: |
Frontiers in Immunology - 13(2022) |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Nayara Gomes Graciliano [VerfasserIn] |
---|
Links: |
doi.org [kostenfrei] |
---|
Themen: |
Antibodies |
---|
doi: |
10.3389/fimmu.2022.1031248 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
DOAJ002226987 |
---|
LEADER | 01000caa a22002652 4500 | ||
---|---|---|---|
001 | DOAJ002226987 | ||
003 | DE-627 | ||
005 | 20230307022042.0 | ||
007 | cr uuu---uuuuu | ||
008 | 230225s2022 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.3389/fimmu.2022.1031248 |2 doi | |
035 | |a (DE-627)DOAJ002226987 | ||
035 | |a (DE-599)DOAJ72b066621214451ebccb5d37c2becfa9 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
050 | 0 | |a RC581-607 | |
100 | 0 | |a Nayara Gomes Graciliano |e verfasserin |4 aut | |
245 | 1 | 4 | |a The impact on colostrum oxidative stress, cytokines, and immune cells composition after SARS-CoV-2 infection during pregnancy |
264 | 1 | |c 2022 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a Computermedien |b c |2 rdamedia | ||
338 | |a Online-Ressource |b cr |2 rdacarrier | ||
520 | |a BackgroundLimited data are available regarding the differences between immunological, biochemical, and cellular contents of human colostrum following maternal infection during pregnancy with coronavirus 2 disease (COVID-19).ObjectiveTo investigate whether maternal COVID-19 infection may affect immunological, biochemical, and cellular contents of human colostrum.MethodsUsing a case-control study design, we collected colostrum from 14 lactating women with a previous diagnosis of COVID-19 during pregnancy and 12 without a clear diagnosis during September 2020 to May 2021. Colostrum samples were analysed for some enzymes and non-enzymatic oxidative stress markers (SOD, CAT, GPx, MDA, GSH, GSSG, H2O2, MPO) and for IL-1β, IL-6, tumour necrosis factor (TNF)-α, protein induced by interferon gamma (IP)-10, IL-8, IFN-λ1, IL12p70, IFN-α2, IFN-λ2/3, granulocyte macrophage colony stimulating factor (GM-CSF), IFN-β, IL-10 and IFN-γ, along with IgA and IgG for the SARS-CoV-2 S protein. We perform immunophenotyping to assess the frequency of different cell types in the colostrum.ResultsColostrum from the COVID-19 symptomatic group in pregnancy contained reduced levels of H2O2, IFN-α2, and GM-CSF. This group had higher levels of GSH, and both NK cell subtypes CD3-CD56brightCD16-CD27+IFN-γ+ and CD3-CD56dimCD16+CD27- were also increased.ConclusionThe present results reinforce the protective role of colostrum even in the case of mild SARS-Cov-2 infection, in addition to demonstrating how adaptive the composition of colostrum is after infections. It also supports the recommendation to encourage lactating women to continue breastfeeding after COVID-19 illness. | ||
650 | 4 | |a antibodies | |
650 | 4 | |a breastfeeding | |
650 | 4 | |a COVID-19 | |
650 | 4 | |a human milk | |
650 | 4 | |a immunoglobulins | |
650 | 4 | |a IgA | |
653 | 0 | |a Immunologic diseases. Allergy | |
700 | 0 | |a Micaely Cristinados Santos Tenório |e verfasserin |4 aut | |
700 | 0 | |a Marilene Brandão Tenório Fragoso |e verfasserin |4 aut | |
700 | 0 | |a Fabiana Andréa Moura |e verfasserin |4 aut | |
700 | 0 | |a Rayane Martins Botelho |e verfasserin |4 aut | |
700 | 0 | |a Eloiza Lopes Lira Tanabe |e verfasserin |4 aut | |
700 | 0 | |a Karen Steponavicius Cruz Borbely |e verfasserin |4 aut | |
700 | 0 | |a Alexandre Urban Borbely |e verfasserin |4 aut | |
700 | 0 | |a Alane Cabral Menezes Oliveira |e verfasserin |4 aut | |
700 | 0 | |a Alane Cabral Menezes Oliveira |e verfasserin |4 aut | |
700 | 0 | |a Marília Oliveira Fonseca Goulart |e verfasserin |4 aut | |
700 | 0 | |a Marília Oliveira Fonseca Goulart |e verfasserin |4 aut | |
700 | 0 | |a Marília Oliveira Fonseca Goulart |e verfasserin |4 aut | |
773 | 0 | 8 | |i In |t Frontiers in Immunology |d Frontiers Media S.A., 2011 |g 13(2022) |w (DE-627)DOAJ000031690 |x 16643224 |7 nnns |
773 | 1 | 8 | |g volume:13 |g year:2022 |
856 | 4 | 0 | |u https://doi.org/10.3389/fimmu.2022.1031248 |z kostenfrei |
856 | 4 | 0 | |u https://doaj.org/article/72b066621214451ebccb5d37c2becfa9 |z kostenfrei |
856 | 4 | 0 | |u https://www.frontiersin.org/articles/10.3389/fimmu.2022.1031248/full |z kostenfrei |
856 | 4 | 2 | |u https://doaj.org/toc/1664-3224 |y Journal toc |z kostenfrei |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_DOAJ | ||
951 | |a AR | ||
952 | |d 13 |j 2022 |