A large-scale clinical validation study using nCapp cloud plus terminal by frontline doctors for the rapid diagnosis of COVID-19 and COVID-19 pneumonia in China
Background: The outbreak of coronavirus disease 2019 (COVID-19) has become a global pandemic acute infectious disease, especially with the features of possible asymptomatic carriers and high contagiousness. Currently, it is difficult to quickly identify asymptomatic cases or COVID-19 patients with pneumonia due to limited access to reverse transcription-polymerase chain reaction (RT-PCR) nucleic acid tests and CT scans. Goal: This study aimed to develop a scientific and rigorous clinical diagnostic tool for the rapid prediction of COVID-19 cases based on a COVID-19 clinical case database in China, and to assist doctors to efficiently and precisely diagnose asymptomatic COVID-19 patients and cases who had a false-negative RT-PCR test result. Methods: With online consent, and the approval of the ethics committee of Zhongshan Hospital Fudan University (NCT04275947, B2020-032R) to ensure that patient privacy is protected, clinical information has been uploaded in real-time through the New Coronavirus Intelligent Auto-diagnostic Assistant Application of cloud plus terminal (nCapp) by doctors from different cities (Wuhan, Shanghai, Harbin, Dalian, Wuxi, Qingdao, Rizhao, and Bengbu) during the COVID-19 outbreak in China. By quality control and data anonymization on the platform, a total of 3,249 cases from COVID-19 high-risk groups were collected. The effects of different diagnostic factors were ranked based on the results from a single factor analysis, with 0.05 as the significance level for factor inclusion and 0.1 as the significance level for factor exclusion. Independent variables were selected by the step-forward multivariate logistic regression analysis to obtain the probability model. Findings: We applied the statistical method of a multivariate regression model to the training dataset (1,624 cases) and developed a prediction model for COVID-19 with 9 clinical indicators that are accessible. The area under the receiver operating characteristic (ROC) curve (AUC) for the model was 0.88 (95% CI: 0.86, 0.89) in the training dataset and 0.84 (95% CI: 0.82, 0.86) in the validation dataset (1,625 cases). Discussion: With the assistance of nCapp, a mobile-based diagnostic tool developed from a large database that we collected from COVID-19 high-risk groups in China, frontline doctors can rapidly identify asymptomatic patients and avoid misdiagnoses of cases with false-negative RT-PCR results..
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2022 |
---|---|
Erschienen: |
2022 |
Enthalten in: |
Zur Gesamtaufnahme - volume:5 |
---|---|
Enthalten in: |
Clinical eHealth - 5(2022), Seite 79-90 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Dawei Yang [VerfasserIn] |
---|
Links: |
doi.org [kostenfrei] |
---|
Themen: |
COVID-19 |
---|
doi: |
10.1016/j.ceh.2022.07.004 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
DOAJ001102184 |
---|
LEADER | 01000caa a22002652 4500 | ||
---|---|---|---|
001 | DOAJ001102184 | ||
003 | DE-627 | ||
005 | 20230502140217.0 | ||
007 | cr uuu---uuuuu | ||
008 | 230225s2022 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1016/j.ceh.2022.07.004 |2 doi | |
035 | |a (DE-627)DOAJ001102184 | ||
035 | |a (DE-599)DOAJ1e7a4c31f2504fea9b2777779f5e500b | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 0 | |a Dawei Yang |e verfasserin |4 aut | |
245 | 1 | 2 | |a A large-scale clinical validation study using nCapp cloud plus terminal by frontline doctors for the rapid diagnosis of COVID-19 and COVID-19 pneumonia in China |
264 | 1 | |c 2022 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a Computermedien |b c |2 rdamedia | ||
338 | |a Online-Ressource |b cr |2 rdacarrier | ||
520 | |a Background: The outbreak of coronavirus disease 2019 (COVID-19) has become a global pandemic acute infectious disease, especially with the features of possible asymptomatic carriers and high contagiousness. Currently, it is difficult to quickly identify asymptomatic cases or COVID-19 patients with pneumonia due to limited access to reverse transcription-polymerase chain reaction (RT-PCR) nucleic acid tests and CT scans. Goal: This study aimed to develop a scientific and rigorous clinical diagnostic tool for the rapid prediction of COVID-19 cases based on a COVID-19 clinical case database in China, and to assist doctors to efficiently and precisely diagnose asymptomatic COVID-19 patients and cases who had a false-negative RT-PCR test result. Methods: With online consent, and the approval of the ethics committee of Zhongshan Hospital Fudan University (NCT04275947, B2020-032R) to ensure that patient privacy is protected, clinical information has been uploaded in real-time through the New Coronavirus Intelligent Auto-diagnostic Assistant Application of cloud plus terminal (nCapp) by doctors from different cities (Wuhan, Shanghai, Harbin, Dalian, Wuxi, Qingdao, Rizhao, and Bengbu) during the COVID-19 outbreak in China. By quality control and data anonymization on the platform, a total of 3,249 cases from COVID-19 high-risk groups were collected. The effects of different diagnostic factors were ranked based on the results from a single factor analysis, with 0.05 as the significance level for factor inclusion and 0.1 as the significance level for factor exclusion. Independent variables were selected by the step-forward multivariate logistic regression analysis to obtain the probability model. Findings: We applied the statistical method of a multivariate regression model to the training dataset (1,624 cases) and developed a prediction model for COVID-19 with 9 clinical indicators that are accessible. The area under the receiver operating characteristic (ROC) curve (AUC) for the model was 0.88 (95% CI: 0.86, 0.89) in the training dataset and 0.84 (95% CI: 0.82, 0.86) in the validation dataset (1,625 cases). Discussion: With the assistance of nCapp, a mobile-based diagnostic tool developed from a large database that we collected from COVID-19 high-risk groups in China, frontline doctors can rapidly identify asymptomatic patients and avoid misdiagnoses of cases with false-negative RT-PCR results. | ||
650 | 4 | |a COVID-19 | |
650 | 4 | |a SARS-CoV-2 | |
650 | 4 | |a Smartphone | |
650 | 4 | |a WeChat | |
650 | 4 | |a Infectious disease | |
653 | 0 | |a Medicine | |
653 | 0 | |a R | |
700 | 0 | |a Tao Xu |e verfasserin |4 aut | |
700 | 0 | |a Xun Wang |e verfasserin |4 aut | |
700 | 0 | |a Deng Chen |e verfasserin |4 aut | |
700 | 0 | |a Ziqiang Zhang |e verfasserin |4 aut | |
700 | 0 | |a Lichuan Zhang |e verfasserin |4 aut | |
700 | 0 | |a Jie Liu |e verfasserin |4 aut | |
700 | 0 | |a Kui Xiao |e verfasserin |4 aut | |
700 | 0 | |a Li Bai |e verfasserin |4 aut | |
700 | 0 | |a Yong Zhang |e verfasserin |4 aut | |
700 | 0 | |a Lin Zhao |e verfasserin |4 aut | |
700 | 0 | |a Lin Tong |e verfasserin |4 aut | |
700 | 0 | |a Chaomin Wu |e verfasserin |4 aut | |
700 | 0 | |a Yaoli Wang |e verfasserin |4 aut | |
700 | 0 | |a Chunling Dong |e verfasserin |4 aut | |
700 | 0 | |a Maosong Ye |e verfasserin |4 aut | |
700 | 0 | |a Yu Xu |e verfasserin |4 aut | |
700 | 0 | |a Zhenju Song |e verfasserin |4 aut | |
700 | 0 | |a Hong Chen |e verfasserin |4 aut | |
700 | 0 | |a Jing Li |e verfasserin |4 aut | |
700 | 0 | |a Jiwei Wang |e verfasserin |4 aut | |
700 | 0 | |a Fei Tan |e verfasserin |4 aut | |
700 | 0 | |a Hai Yu |e verfasserin |4 aut | |
700 | 0 | |a Jian Zhou |e verfasserin |4 aut | |
700 | 0 | |a Chunhua Du |e verfasserin |4 aut | |
700 | 0 | |a Hongqing Zhao |e verfasserin |4 aut | |
700 | 0 | |a Yu Shang |e verfasserin |4 aut | |
700 | 0 | |a Linian Huang |e verfasserin |4 aut | |
700 | 0 | |a Jianping Zhao |e verfasserin |4 aut | |
700 | 0 | |a Yang Jin |e verfasserin |4 aut | |
700 | 0 | |a Charles A. Powell |e verfasserin |4 aut | |
700 | 0 | |a Jinming Yu |e verfasserin |4 aut | |
700 | 0 | |a Yuanlin Song |e verfasserin |4 aut | |
700 | 0 | |a Chunxue Bai |e verfasserin |4 aut | |
773 | 0 | 8 | |i In |t Clinical eHealth |d KeAi Communications Co., Ltd., 2019 |g 5(2022), Seite 79-90 |w (DE-627)DOAJ000143405 |x 25889141 |7 nnns |
773 | 1 | 8 | |g volume:5 |g year:2022 |g pages:79-90 |
856 | 4 | 0 | |u https://doi.org/10.1016/j.ceh.2022.07.004 |z kostenfrei |
856 | 4 | 0 | |u https://doaj.org/article/1e7a4c31f2504fea9b2777779f5e500b |z kostenfrei |
856 | 4 | 0 | |u http://www.sciencedirect.com/science/article/pii/S2588914122000193 |z kostenfrei |
856 | 4 | 2 | |u https://doaj.org/toc/2588-9141 |y Journal toc |z kostenfrei |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_DOAJ | ||
912 | |a SSG-OLC-PHA | ||
951 | |a AR | ||
952 | |d 5 |j 2022 |h 79-90 |