脑啡肽酶抑制剂对心力衰竭患者认知功能的研究进展 : = Enkephalase Inhibitors on Cognitive Function in Patients with Heart Failure
沙库巴曲/缬沙坦在治疗左室射血分数降低性慢性心力衰竭中,是通过抑制脑啡肽酶来提高利钠肽的浓度从而起到治疗作用。但同时它还增加了血管活性肽、神经肽和β-淀粉样蛋白的水平。理论上讲,增加β-淀粉样蛋白可以增加服用本药患者认知功能障碍的风险,现就长期使用脑啡肽酶抑制剂对心力衰竭患者认知功能影响的各种观点进行综述。.
Sacubitril/valsartan is effective in treating chronic heart failure with reduced left ventricular ejection fraction by inhibiting neprilysin and increasing the natriuretic peptides. However,it also increases levels of vasoactive peptides,neuropeptides,and β-amyloid( Aβ). In theory,elvated Aβ could increase the risk of cognitive impairment in patients taking the drug. This article will review the effects of long-term neprilysin inhibition on cognitive function in patients with heart failure..
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020-01-22 17:12 2019 |
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| Erschienen: |
2020-01-22 17:12 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2019 |
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| Enthalten in: |
Xin xie guan bing xue jin zhan - (2019), 09 vom: 22 17:12. Jan., Seite 1253-1256 Original Letters: Enthalten in 心血管病学进展 (DE-600)2994663-3 (DE-600)2994663-3 四川省成都市 |
| Reihe: |
China Academic Journals (CAJ), E, 医药卫生科技 = Medicine & Public Health |
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| Sprache: |
Chinesisch |
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| Weiterer Titel: |
Enkephalase Inhibitors on Cognitive Function in Patients with Heart Failure |
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| Beteiligte Personen: |
王双 [VerfasserIn] |
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| Links: |
oversea.cnki.net [lizenzpflichtig] |
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| Anmerkungen: |
Author info:WANG Shuang;FENG Jinghui;WU Lixin;FU Junbo;WU Xiuping;Department of Geriatrics,The First Affiliated Hospital of Harbin Medical University |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
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| 520 | |a 沙库巴曲/缬沙坦在治疗左室射血分数降低性慢性心力衰竭中,是通过抑制脑啡肽酶来提高利钠肽的浓度从而起到治疗作用。但同时它还增加了血管活性肽、神经肽和β-淀粉样蛋白的水平。理论上讲,增加β-淀粉样蛋白可以增加服用本药患者认知功能障碍的风险,现就长期使用脑啡肽酶抑制剂对心力衰竭患者认知功能影响的各种观点进行综述。 | ||
| 520 | |a Sacubitril/valsartan is effective in treating chronic heart failure with reduced left ventricular ejection fraction by inhibiting neprilysin and increasing the natriuretic peptides. However,it also increases levels of vasoactive peptides,neuropeptides,and β-amyloid( Aβ). In theory,elvated Aβ could increase the risk of cognitive impairment in patients taking the drug. This article will review the effects of long-term neprilysin inhibition on cognitive function in patients with heart failure. | ||
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| 650 | 4 | |a 精神病学 | |
| 650 | 4 | |a 神经病学与精神病学 | |
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| 650 | 4 | |a 心脏、血管（循环系）疾病 | |
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