持续性血液滤过联合高流量吸氧治疗重症急性呼吸综合征的疗效及对血清炎症因子水平的影响 : = Curative Efficacy of Continuous Blood Filtration Combined with High Flow Oxygen Uptake in the Treatment of Severe Acute Respiratory Syndrome and Its Effects on the Serum Inflammatory Factors Levels

目的:探讨持续性血液滤过联合高流量吸氧治疗重症急性呼吸综合征的疗效及对血清炎症因子水平的影响。方法:选择2013年2月至2016年2月我院接诊的60例重症急性呼吸综合征患者,通过随机数表法将其分为观察组(n=30)和对照组(n=30)。观察组采用持续性血液滤过联合高流量吸氧进行治疗,对照组采用持续性血液滤过进行治疗。比较两组临床疗效、治疗前后动脉血氧分压(PaO_2)、动脉血二氧化碳分压(PaCO_2)、氧合指数、氢离子浓度指数(pH)值、呼吸频率(RR)、心率(HR)、血清C反应蛋白(CRP)、白介素6(IL-6)、白介素8(IL-8)、肿瘤坏死因子α(TNF-α)水平的变化及不良反应的发生情况。结果:治疗后,观察组有效率为76.67%,显著高于对照组(50.00%,P<0.05)。两组治疗后PaO_2、PaCO_2、氧合指数、pH值、RR、HR均较治疗前明显改善,观察组患者PaO_2、氧合指数明显高于对照组,PaCO_2、pH值、RR、HR、血清CRP、IL-6、IL-8及TNF-α水平均显著低于对照组(P<0.05)。治疗期间,观察组患者不良反应总发生率(10.00%)显著低于对照组(36.67%,P<0.05);观察组死亡1例(3.33%),对照组死亡6例(20.00%),观察组病死率显著低于对照组(P<0.05)。结论:持续性血液滤过联合高流量吸氧治疗重症急性呼吸综合征患者的临床疗效及安全性明显优于单用持续性血液滤过治疗,可能与其更有效减轻炎症反应有关。.

Objective: To study the curative efficacy of continuous blood filtration combined with high flow oxygen uptake in the treatment of severe acute respiratory syndrome and its effects on the inflammatory factors. Methods: 60 cases of patients with severe acute respiratory syndrome admitted to our hospital from February 2013 to February 2016 were selected and divided into the observation group(n=30) and the control group(n=30) by random number table method. The observation group was treated with continuous hemofiltration combined with high flow oxygen, while the control group was treated with continuous hemofiltration. Clinical efficacy,arterial partial oxygen pressure(PaO_2), arterial partial carbon dioxide pressure(PaCO_2), oxygenation index, hydrogen ion concentration index(pH), respiratory rate(RR), heart rate(HR), serum c-reactive protein(CRP), interleukin-6(il-6), interleukin-8(il-8), and tumor necrosis factor(TNF-α) were compared between the two groups. Results: After treatment, the effective rate of observation group was 76.67%, which was significantly higher than that of the control group(50.00%, P<0.05). After treatment, the PaO_2, PaCO_2, oxygenation index, pH value, RR and HR in both groups were significantly improved compared with those before treatment. The PaO_2 and oxygenation index in the observation group were significantly higher than those in the control group, and the levels of PaCO_2, pH value,RR, HR, serum CRP, IL-6, IL-8 and TNF-α were significantly lower than those in the control group(P<0.05). During the treatment, the total incidence of adverse reactions in the observation group(10.00%) was significantly lower than that in the control group(36.67%,P<0.05). One case died in the observation group(3.33%), and six cases died in the control group(20.00%). The fatality rate of the observation group was significantly lower than that of the control group(P<0.05). Conclusion: The clinical efficacy and safety of continuous hemofiltration combined with high-flow oxygen inhalation in the treatment of patients with severe acute respiratory syndrome are significantly better than that of continuous hemofiltration alone, which may be related to the effective reduction of inflammatory reactions..

Medienart:	E-Artikel

Erscheinungsjahr:	2019-11-30 2019
Erschienen:	2019-11-30

Enthalten in:	Zur Gesamtaufnahme - year:2019
Enthalten in:	Xian dai sheng wu yi xue jin zhan - (2019), 22 vom: 30. Nov., Seite 4303-4307 Original Letters: Enthalten in 现代生物医学进展 (DE-600)2993236-1 (DE-600)2993236-1 黑龙江省哈尔滨市

Reihe:	China Academic Journals (CAJ), E, 医药卫生科技 = Medicine & Public Health

Sprache:	Chinesisch

Weiterer Titel:	Curative Efficacy of Continuous Blood Filtration Combined with High Flow Oxygen Uptake in the Treatment of Severe Acute Respiratory Syndrome and Its Effects on the Serum Inflammatory Factors Levels

Beteiligte Personen:	陈亚强 [VerfasserIn] 刘巧艳 [Sonstige Person] 王子正 [Sonstige Person] 邵泽斌 [Sonstige Person] 房阁 [Sonstige Person]

Links:	oversea.cnki.net [lizenzpflichtig]

Themen:	中国人民解放军空军第九八六医院重症医学科 内科学 医药、卫生 医药卫生科技 呼吸系及胸部疾病 延安大学附属医院重症医学科 持续性血液滤过 炎症因子 重症急性呼吸综合征 高流量吸氧 Continuous blood filtration Disease of Respiratory System Emergency Medicine High flow oxygen Inflammatory cytokines Medicine & Public Health Severe acute respiratory syndrome

Anmerkungen:	Author info:CHEN Ya-qiang;LIU Qiao-yan;WANG Zi-zheng;SHAO Ze-bin;FANG Ge;Department of Critical Care Medicine, The 186th Hospital of Chinese People's Liberation Army Air Force;Department of Critical Care Medicine, Affiliated Hospital of Yan'an University

Förderinstitution / Projekttitel:

PPN (Katalog-ID):	CAJ646036432