HCV与HBV共感染影响血清HBV核酸与表面抗原水平 : = HCV coinfection with HBV impact the level of nucleic acid and HBsAg of HBV in serum
分析和评估HCV与HBV共感染对HBV临床指征的影响。采集152例有静脉吸毒史HBV感染者血浆,其中HBV/HCV共感染组52例,HBV单感染组100例。检测分析包括ALT和AST、HBV表面抗原(HBsAg)、e抗原、e抗体、HBV DNA及anti-HCV IgG与HCV RNA。结果显示,两组样本的ALT和AST水平无显著差异(P=0.097,P=0.184);HBV/HCV共感染组HBsAg水平显著低于HBV单感染组HBsAg水平(P=0.020);共感染组HBV DNA阳性率显著低于HBV单感染组HBV DNA阳性率(P=0.004),且共感染组中HBV DNA载量也显著低于HBV单感染组HBV DNA载量(P=0.031)。进一步分析发现:在HBV单感染患者中的HBV DNA和HBsAg具有良好的正相关关系(r=0.752,P<0.001),但在HBV/HCV共感染患者中相关性减弱(r=0.387,P=0.042)。本研究显示HCV共感染可能与HBV存在竞争关系,从而影响HBV病毒复制水平及表面抗原分泌。.
To analyze and evaluate the effect of HCV coinfection on clinical indicators of HBV-infected patients. 152 individuals with HBV infection from intravenous drug users were enrolled. 52 individuals were HBV/HCV co-infected and 100 individuals were mono-HBV infection. Serum ALT and AST, HBsAg, HBeAg, anti-HBe, HBV DNA and anti-HCV IgG, HCV RNA were measured. The results showed that there was no significant difference in ALT and AST levels between the two groups(P=0.097, P=0.184); The positive rate of HBV DNA in the co-infection group was lower(P=0.004) compared with mono-HBV infection, and the HBsAg level and HBV DNA load in co-infection group were lower than those of mono-HBV infection(P=0.020, P=0.031); there was a positive correlation between HBV DNA and HBsAg in mono-HBV infected individuals(r=0.752, P<0.001), but the correlation is weakened in coinfected individuals(r=0.387, P=0.042). The results of this study suggested HCV coinfection significantly impact HBV replication and HBsAg secretion, which may indicate that HCV coinfection interfere with HBV replication..
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2019-11-15 2019 |
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| Erschienen: |
2019-11-15 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2019 |
|---|---|
| Enthalten in: |
Zhong nan yi xue ke xue za zhi - (2019), 06 vom: 15. Nov., Seite 643-647 Original Letters: Enthalten in 中南医学科学杂志 (DE-600)2993755-3 (DE-600)2993755-3 湖南省衡阳市 |
| Reihe: |
China Academic Journals (CAJ), E, 医药卫生科技 = Medicine & Public Health |
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| Sprache: |
Chinesisch |
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| Weiterer Titel: |
HCV coinfection with HBV impact the level of nucleic acid and HBsAg of HBV in serum |
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| Beteiligte Personen: |
张萍 [VerfasserIn] |
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| Links: |
oversea.cnki.net [lizenzpflichtig] |
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| Anmerkungen: |
Author info:ZHANG Ping;LIU Wenpei;LIN Yingbiao;DAI Guozhi;GUO Wangyuan;JIANG Yanghua;TANG Ping;ZHANG Jian;QU Xiaowang;LUO Dixian;Translational Medicine Institute, the First People's Hospital of Chenzhou, University of South China;Department of Laboratory Medicine, the First People's Hospital of Chenzhou |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
CAJ644137657 |
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| 245 | 1 | 0 | |a HCV与HBV共感染影响血清HBV核酸与表面抗原水平 |b = HCV coinfection with HBV impact the level of nucleic acid and HBsAg of HBV in serum |
| 246 | 3 | 1 | |a HCV coinfection with HBV impact the level of nucleic acid and HBsAg of HBV in serum |
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| 520 | |a 分析和评估HCV与HBV共感染对HBV临床指征的影响。采集152例有静脉吸毒史HBV感染者血浆,其中HBV/HCV共感染组52例,HBV单感染组100例。检测分析包括ALT和AST、HBV表面抗原(HBsAg)、e抗原、e抗体、HBV DNA及anti-HCV IgG与HCV RNA。结果显示,两组样本的ALT和AST水平无显著差异(P=0.097,P=0.184);HBV/HCV共感染组HBsAg水平显著低于HBV单感染组HBsAg水平(P=0.020);共感染组HBV DNA阳性率显著低于HBV单感染组HBV DNA阳性率(P=0.004),且共感染组中HBV DNA载量也显著低于HBV单感染组HBV DNA载量(P=0.031)。进一步分析发现:在HBV单感染患者中的HBV DNA和HBsAg具有良好的正相关关系(r=0.752,P<0.001),但在HBV/HCV共感染患者中相关性减弱(r=0.387,P=0.042)。本研究显示HCV共感染可能与HBV存在竞争关系,从而影响HBV病毒复制水平及表面抗原分泌。 | ||
| 520 | |a To analyze and evaluate the effect of HCV coinfection on clinical indicators of HBV-infected patients. 152 individuals with HBV infection from intravenous drug users were enrolled. 52 individuals were HBV/HCV co-infected and 100 individuals were mono-HBV infection. Serum ALT and AST, HBsAg, HBeAg, anti-HBe, HBV DNA and anti-HCV IgG, HCV RNA were measured. The results showed that there was no significant difference in ALT and AST levels between the two groups(P=0.097, P=0.184); The positive rate of HBV DNA in the co-infection group was lower(P=0.004) compared with mono-HBV infection, and the HBsAg level and HBV DNA load in co-infection group were lower than those of mono-HBV infection(P=0.020, P=0.031); there was a positive correlation between HBV DNA and HBsAg in mono-HBV infected individuals(r=0.752, P<0.001), but the correlation is weakened in coinfected individuals(r=0.387, P=0.042). The results of this study suggested HCV coinfection significantly impact HBV replication and HBsAg secretion, which may indicate that HCV coinfection interfere with HBV replication. | ||
| 610 | 2 | 4 | |a 南华大学附属郴州医院转化医学研究所 |
| 610 | 2 | 4 | |a 郴州市第一人民医院检验医学中心 |
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| 650 | 4 | |a 医药、卫生 | |
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| 650 | 4 | |a Digestive System Disease | |
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| 650 | 4 | |a 乙型肝炎病毒 | |
| 650 | 4 | |a 丙型肝炎病毒 | |
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| 650 | 4 | |a 表面抗原 | |
| 650 | 4 | |a 病毒载量 | |
| 650 | 4 | |a hepatitis B virus | |
| 650 | 4 | |a hepatitis C virus | |
| 650 | 4 | |a coinfection | |
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