Differential effects of atrial and brain natriuretic peptides on human pulmonary artery:An in vitro study : = Differential effects of atrial and brain natriuretic peptides on human pulmonary artery:An in vitro study
BACKGROUND The prevalence of cardiovascular diseases, especially heart failure, continues to rise worldwide. In heart failure, increasing levels of circulating atrial natriuretic peptide(ANP) and brain natriuretic peptide(BNP) are associated with a worsening of heart failure and a poor prognosis.AIM To test whether a high concentration of BNP would inhibit relaxation to ANP.METHODS Pulmonary arteries were dissected from disease-free areas of lung resection, as well as pulmonary artery rings of internal diameter 2.5–3.5 mm and 2 mm long,were prepared. Pulmonary artery rings were mounted in a multiwire myograph,and a basal tension of 1.61 gf was applied. After equilibration for 60 min, rings were pre-constricted with 11.21 μmol/L PGF_(2α)(EC_(80)), and concentration response curves were constructed to vasodilators by cumulative addition to the myograph chambers.RESULTS Although both ANP and BNP were found to vasodilate the pulmonary vessels,ANP is more potent than BNP.pEC50 of ANP and BNP were 8.96 ± 0.21 and 7.54± 0.18, respectively, and the maximum efficacy(E_(max)) for ANP and BNP was-2.03 gf and-0.24 gf, respectively. After addition of BNP, the E_(max) of ANP reduced from -0.96 gf to-0.675 gf(P=0.28).CONCLUSION BNP could be acting as a partial agonist in small human pulmonary arteries, and inhibits relaxation to ANP. Elevated levels of circulating BNP could be responsible for the worsening of decompensated heart failure. This finding could also explain the disappointing results seen in clinical trials of ANP and BNP analogues for the treatment of heart failure..
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2019-10-26 2019 |
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| Erschienen: |
2019-10-26 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2019 |
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| Enthalten in: |
World Journal of Cardiology = 世界心脏病学杂志(电子版)(英文版) - (2019), 10 vom: 26. Okt., Seite 236-243 Original Letters: Enthalten in (DE-627)CAJ470419962 (DE-627)CAJ470419962 |
| Reihe: |
China Academic Journals (CAJ), E, 医药卫生科技 = Medicine & Public Health |
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| Sprache: |
Chinesisch |
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| Weiterer Titel: |
Differential effects of atrial and brain natriuretic peptides on human pulmonary artery:An in vitro study |
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| Beteiligte Personen: |
Azar Hussain [VerfasserIn] |
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| Links: |
oversea.cnki.net [lizenzpflichtig] |
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| Anmerkungen: |
Author info:Azar Hussain;Robert T Bennett;Zaheer Tahir;Emmanuel Isaac;Mubarak A Chaudhry;Syed S Qadri;Mahmoud Loubani;Alyn H Morice;Department of Cardiothoracic Surgery, Castle Hill Hospital;Centre for Cardiovascular and Metabolic Research, Hull York Medical School,Castle Hill Hospital |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
CAJ643954449 |
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| 245 | 1 | 0 | |a Differential effects of atrial and brain natriuretic peptides on human pulmonary artery:An in vitro study |b = Differential effects of atrial and brain natriuretic peptides on human pulmonary artery:An in vitro study |
| 246 | 3 | 1 | |a Differential effects of atrial and brain natriuretic peptides on human pulmonary artery:An in vitro study |
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| 500 | |a Author info:Azar Hussain;Robert T Bennett;Zaheer Tahir;Emmanuel Isaac;Mubarak A Chaudhry;Syed S Qadri;Mahmoud Loubani;Alyn H Morice;Department of Cardiothoracic Surgery, Castle Hill Hospital;Centre for Cardiovascular and Metabolic Research, Hull York Medical School,Castle Hill Hospital | ||
| 520 | |a BACKGROUND The prevalence of cardiovascular diseases, especially heart failure, continues to rise worldwide. In heart failure, increasing levels of circulating atrial natriuretic peptide(ANP) and brain natriuretic peptide(BNP) are associated with a worsening of heart failure and a poor prognosis.AIM To test whether a high concentration of BNP would inhibit relaxation to ANP.METHODS Pulmonary arteries were dissected from disease-free areas of lung resection, as well as pulmonary artery rings of internal diameter 2.5–3.5 mm and 2 mm long,were prepared. Pulmonary artery rings were mounted in a multiwire myograph,and a basal tension of 1.61 gf was applied. After equilibration for 60 min, rings were pre-constricted with 11.21 μmol/L PGF_(2α)(EC_(80)), and concentration response curves were constructed to vasodilators by cumulative addition to the myograph chambers.RESULTS Although both ANP and BNP were found to vasodilate the pulmonary vessels,ANP is more potent than BNP.pEC50 of ANP and BNP were 8.96 ± 0.21 and 7.54± 0.18, respectively, and the maximum efficacy(E_(max)) for ANP and BNP was-2.03 gf and-0.24 gf, respectively. After addition of BNP, the E_(max) of ANP reduced from -0.96 gf to-0.675 gf(P=0.28).CONCLUSION BNP could be acting as a partial agonist in small human pulmonary arteries, and inhibits relaxation to ANP. Elevated levels of circulating BNP could be responsible for the worsening of decompensated heart failure. This finding could also explain the disappointing results seen in clinical trials of ANP and BNP analogues for the treatment of heart failure. | ||
| 610 | 2 | 4 | |a Department of Cardiothoracic Surgery, Castle Hill Hospital |
| 610 | 2 | 4 | |a Centre for Cardiovascular and Metabolic Research, Hull York Medical School,Castle Hill Hospital |
| 650 | 4 | |a 心脏、血管（循环系）疾病 | |
| 650 | 4 | |a 内科学 | |
| 650 | 4 | |a 医药、卫生 | |
| 650 | 4 | |a Cardiovascular System Disease | |
| 650 | 4 | |a 医药卫生科技 | |
| 650 | 4 | |a Medicine & Public Health | |
| 650 | 4 | |a Heart failure | |
| 650 | 4 | |a Atrial natriuretic peptide | |
| 650 | 4 | |a Brain natriuretic peptide | |
| 650 | 4 | |a In-vitro | |
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| 700 | 0 | |a Mahmoud Loubani |4 oth | |
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