高龄肺癌患者的临床特征及预后因素 : = Clinicopathologic features and prognostic factors of elderly patients with lung cancer

目的:探讨高龄肺癌患者的临床特征及预后因素。方法:回顾性分析安徽省胸科医院2014年1月—2017年12月收治的128例75岁以上高龄肺癌患者的病历资料或电子记录,采用Log-rank法对影响患者总生存期(overall survival,OS)和无进展生存期(progression-free survival,PFS)的因素进行单因素分析,并使用Kplan-Meier法绘制生存曲线;采用COX风险比例回归模型对影响高龄肺癌患者OS和PFS的因素进行多因素分析,并计算风险比(hazard ratio,HR)。结果:128例高龄肺癌患者的中位生存期(median overall survival,mOS)为15.7个月(12.8～18.8个月),1、3及5年OS率分别为58.40%、24.25%和17.78%;中位无进展生存期(median progression-free survival,mPFS)为8.5个月(5.5～11.5个月),1、3及5年PFS率分别为40.00%、13.66%和10.24%。美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)评分、疾病分期、肝转移、手术治疗、神经元特异性烯醇化酶(neuron-specic enolase,NSE)、乳酸脱氢酶(lactate dehydrogenase,LDH)、血清总蛋白(total protein,TP)和碱性磷酸酶(alkaline phosphatase,ALP)与mOS有关(P值均<0.05),合并基础疾病、ECOG评分、疾病分期、肺内转移、血清癌胚抗原(carcino-embryonic antigen,CEA)、NSE、TP和LDH与mPFS有关(P值均<0.05)。ECOG评分(HR=2.510,P=0.001)、肝转移(HR=3.567,P=0.027)、LDH(HR=2.655,P <0.001)和ALP(HR=2.206,P=0.018)是mOS的独立影响因素,ECOG评分(HR=1.795,P=0.043)、肺转移(HR=2.234,P=0.013)、LDH(HR=1.985,P=0.011)、TP(HR=1.802,P=0.018)是mPFS的独立影响因素。结论:ECOG评分和LDH等因素影响高龄肺癌患者的预后。.

Objective: To investigate the clinicopathologic features and prognostic factors of elderly patients with lung cancer.Methods: The case data or electronic records of 128 elderly patients with lung cancer over the age of 75 years admitted to Anhui Chest Hospital during January 2014 to December2017 were analyzed retrospectively. Univariate analysis of the factors affecting overall survival(OS) and progression-free survival(PFS) was performed using Log-rank method, and the survival curves were plotted using Kplan-Meier method. Multivariate analyze of the influencing factors for OS and PFS was performed using COX regression hazards model, and the hazard ratio(HR) was calculated.Results: The median overall survival(mOS) of 128 elderly patients with lung cancer was 15.7 months(12.8-18.8 months), and the 1-, 3-and 5-year OS rates were 58.40%, 24.25% and17.78%, respectively. The median progression-free survival(mPFS) was 8.5 months(5.5-11.5 months), and the 1-, 3-and 5-year PFS rates were 40.00%, 13.66% and 10.24%, respectively.Eastern Cooperative Oncology Group(ECOG) score, pathological stage, liver metastasis, surgical treatment, neuron-specific enolase(NSE), lactate dehydrogenase(LDH), serum total protein(TP)and alkaline phosphatase(ALP) were significantly correlated to mOS(all P < 0.05). Complication with underlying diseases, ECOG score, pathological stage, lung metastasis, carcino-embryonic antigen(CEA), NSE, TP and LDH were significantly correlated to mPFS(all P < 0.05). ECOG score(HR =2.510, P = 0.001), liver metastasis(HR = 2.510, P = 0.001), LDH(HR = 2.655, P < 0.001) and ALP(HR = 2.206, P = 0.018) were independent prognosis factors for the mOS. ECOG score(HR = 1.795,P = 0.043), lung metastasis(HR = 2.234, P = 0.013), LDH(HR = 1.985, P = 0.011) and TP(HR =1.802, P = 0.018) were independent prognostic factors for the mPFS.Conclusion: The factors such as ECOG score and LDH affect the prognosis of elderly patients with lung cancer.

Medienart:	E-Artikel

Erscheinungsjahr:	2019-11-20 15:35 2019
Erschienen:	2019-11-20 15:35

Enthalten in:	Zur Gesamtaufnahme - year:2019
Enthalten in:	Zhong liu - (2019), 11 vom: 20 15:35. Nov., Seite 924-930+948 Original Letters: Enthalten in 肿瘤 (DE-600)2993189-7 (DE-600)2993189-7 上海市

Reihe:	China Academic Journals (CAJ), E, 医药卫生科技 = Medicine & Public Health

Sprache:	Chinesisch

Weiterer Titel:	Clinicopathologic features and prognostic factors of elderly patients with lung cancer

Beteiligte Personen:	徐凌 [VerfasserIn] 程宇 [Sonstige Person] 任静 [Sonstige Person] 吕莉萍 [Sonstige Person]

Links:	oversea.cnki.net [lizenzpflichtig]

Themen:	医药、卫生 医药卫生科技 呼吸系肿瘤 存活率 安徽省胸科医院介入肺脏病科 安徽省胸科医院肿瘤科 老年人 肺肿瘤 肿瘤学 预后 Aged Lung neoplasms Medicine & Public Health Oncology Prognosis Survival rate

Anmerkungen:	Author info:XU Ling;CHENG Yu;REN Jing;Lü Liping;Department of Interventional Pulmonology, Anhui Chest Hospital;Department of Oncology, Anhui Chest Hospital

Förderinstitution / Projekttitel:

PPN (Katalog-ID):	CAJ643803203