基于分子对接的反向虚拟筛选方法 : = Docking-based Inverse Virtual Screening Approach
基于分子对接的反向虚拟筛选方法在药物靶点确定、老药新用以及药物副作用/毒理研究领域具有重要的应用前景,吸引了药物发现领域研究人员的广泛关注.首先对分子对接方法和蛋白质数据库进行细致的介绍,然后列举目前可以用于反向虚拟筛选的网络服务器,并列举该方法在药物设计领域的一些具体应用,最后对该方法目前所存在的问题进行讨论..
Docking-based inverse virtual screening( IVS) has attracted much attention in the drug discovery field,due to its applications in target identification,drug repositioning,and side effects/toxicity prediction. First,molecular docking methods and protein target database were introduced in details. Then,currently available web servers were briefly reviewed. A number of applications in the field of drug design were also presented. Finally,challenges of the methods were discussed..
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2019-11-10 2019 |
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| Erschienen: |
2019-11-10 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2019 |
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| Enthalten in: |
Bei jing gong ye da xue xue bao - (2019), 11 vom: 10. Nov., Seite 1164-1172 Original Letters: Enthalten in 北京工业大学学报 (DE-600)2988945-5 (DE-600)2988945-5 北京市 |
| Reihe: |
China Academic Journals (CAJ), E, 医药卫生科技 = Medicine & Public Health |
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| Sprache: |
Chinesisch |
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| Weiterer Titel: |
Docking-based Inverse Virtual Screening Approach |
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| Beteiligte Personen: |
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| Links: |
oversea.cnki.net [lizenzpflichtig] |
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| Anmerkungen: |
Author info:WANG Cunxin;XU Xianjin;College of Life Science and Bioengineering,Beijing University of Technology;Dalton Cardiovascular Research Center,University of Missouri-Columbia |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
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| 520 | |a 基于分子对接的反向虚拟筛选方法在药物靶点确定、老药新用以及药物副作用/毒理研究领域具有重要的应用前景,吸引了药物发现领域研究人员的广泛关注.首先对分子对接方法和蛋白质数据库进行细致的介绍,然后列举目前可以用于反向虚拟筛选的网络服务器,并列举该方法在药物设计领域的一些具体应用,最后对该方法目前所存在的问题进行讨论. | ||
| 520 | |a Docking-based inverse virtual screening( IVS) has attracted much attention in the drug discovery field,due to its applications in target identification,drug repositioning,and side effects/toxicity prediction. First,molecular docking methods and protein target database were introduced in details. Then,currently available web servers were briefly reviewed. A number of applications in the field of drug design were also presented. Finally,challenges of the methods were discussed. | ||
| 610 | 2 | 4 | |a 北京工业大学生命科学与生物工程学院 |
| 610 | 2 | 4 | |a 密苏里大学-哥伦比亚分校道尔顿心血管研究中心 |
| 650 | 4 | |a 药物基础科学、药物分析 | |
| 650 | 4 | |a 药学 | |
| 650 | 4 | |a 医药、卫生 | |
| 650 | 4 | |a Pharmaceutics | |
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| 650 | 4 | |a 医药卫生科技 | |
| 650 | 4 | |a Medicine & Public Health | |
| 650 | 4 | |a 反向虚拟筛选 | |
| 650 | 4 | |a 分子对接 | |
| 650 | 4 | |a 药物发现 | |
| 650 | 4 | |a 药物靶点确定 | |
| 650 | 4 | |a 老药新用 | |
| 650 | 4 | |a 毒副作用 | |
| 650 | 4 | |a inverse virtual screening | |
| 650 | 4 | |a molecular docking | |
| 650 | 4 | |a drug discovery | |
| 650 | 4 | |a target identification | |
| 650 | 4 | |a drug repositioning | |
| 650 | 4 | |a side effects/toxicity | |
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